Meta‐analysis of randomized controlled trials comparing standard clinical doses of omeprazole and lansoprazole in erosive oesophagitis
Open accessAbstract
Background: Omeprazole and lansoprazole are used to treat erosive oesophagitis in the respective daily doses of 20 and 30 mg. Aim: To investigate, by meta‐analysis, whether treatment with lansoprazole 30 mg increases erosive oesophagitis healing rates over omeprazole 20 mg. Methods: We searched for randomized, double‐blind trials comparing omeprazole 20 mg and lansoprazole 30 mg in endoscopically diagnosed erosive oesophagitis. After assessing for homogeneity, non‐heterogeneous trials were combined and pooled healing rates derived. We calculated the relative benefit increase, absolute benefit increase and number needed to treat. Results: Six trials without significant heterogeneity met predetermined inclusion criteria. By per protocol analysis, pooled healing rates for omeprazole 20 mg and lansoprazole 30 mg were, respectively, 74.7% and 77.7% after 4 weeks and 87.0% and 88.7% after 8 weeks. The corresponding figures by intention‐to‐treat analysis were 70.8% and 72.7% after 4 weeks and 81.8% and 83.3% after 8 weeks. In each analysis the absolute benefit increase for lansoprazole was small and its 95% confidence interval encompassed zero. Conclusion: Lansoprazole 30 mg produces healing rates in erosive oesophagitis that are not statistically significantly different to those of omeprazole 20 mg.
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PPIs are the first-choice treatment for acid-related disorders such as bleeding, peptic ulcers, gastroesophageal reflux, erosive esophagitis (ERD) and certain dyspepsia subtypes.
“PPIs are the first-choice treatment for acid-related disorders such as bleeding, peptic ulcers, gastroesophageal reflux, erosive esophagitis (ERD) and certain dyspepsia subtypes[2-5].”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [4]
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- Authors
- Sharma, V. K., Leontiadis, G. I., & Howden, C. W.
- Affiliations
- University of Arkansas for Medical Sciences (US)
- G. Papanikolaou General Hospital (GR)
- Northwestern University (US)
- Corresponding author
- Howden, C. W.
- ORCID
- Howden, C. W.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2001-02-05
- Volume
- 15
- Issue
- 2
- Pages
- 227-231
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W1984465775
- Cited by
- 64
- References
- 21
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 4 · 2019: 2 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 3
- FWCI
- 4.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Alimentary Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Health Sciences › Dentistry › Orthodontics › Dental Erosion and Treatment
- Health Sciences › Medicine › Surgery › Esophageal and GI Pathology
- Keywords
- erosive esophagitis, omeprazole, lansoprazole, proton pump inhibitors, drug efficacy comparison, number needed to treat
- MeSH terms
- Anti-Ulcer Agents, Esophagitis, Humans, Omeprazole, Randomized Controlled Trials as Topic, Treatment Outcome, 2-Pyridinylmethylsulfinylbenzimidazoles, Lansoprazole
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