Cited by 169Inflammatory Bowel DiseaseIron Metabolism and DisordersAntioxidant Activity and Oxidative Stress

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Effect of oral iron supplementation on oxidative stress and colonic inflammation in rats with induced colitis

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Carrier, J., Aghdassi, E., Platt, I., Cullen, J., Allard, J. P.·2001·Alimentary Pharmacology & Therapeutics

DOI 10.1046/j.1365-2036.2001.01113.x

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Abstract

BACKGROUND: Iron supplementation may increase disease activity in ulcerative colitis, possibly through the production of reactive oxygen species from the Fenton reaction. AIM: To assess the effects of two doses of oral iron on intestinal inflammation and oxidative stress in experimental colitis. METHODS: Colitis was induced in rats by giving 5% dextran sulphate sodium in drinking water for 7 days. First, using a 2 x 2 factorial design, rats with or without dextran sulphate sodium received the regular diet or a diet containing iron 3%/kg diet. Second, rats with dextran sulphate sodium-induced colitis were supplemented with iron 0.3%/kg diet and compared with rats on dextran sulphate sodium and regular diet. The body weight change, histological scores, colon length, rectal bleeding, plasma and colonic lipid peroxides, colonic glutathione peroxidase and plasma vitamin E and C were measured. Faecal analysis for haem and total, free and ethylenediaminetetra-acetic acid-chelatable iron was also performed. RESULTS: Iron 3% and iron 0.3% increased the activity of dextran sulphate sodium-induced colitis, as demonstrated by higher histological scores, heavier rectal bleeding and further shortening of the colon. This was associated with increased lipid peroxidation and decreased antioxidant vitamins. Faecal iron available to the Fenton reaction was increased in a dose-dependent manner. CONCLUSIONS: Iron supplementation taken orally enhanced the activity of dextran sulphate sodium-induced colitis and is associated with an increase in oxidative stress.

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Authors: Carrier, J., Aghdassi, E., Platt, I., Cullen, J., & Allard, J. P.
Affiliations: University of Toronto (CA)
St Joseph's Health Centre (CA)
Corresponding author: Allard, J. P.
ORCID: Platt, I.
Allard, J. P.
Venue: Alimentary Pharmacology & Therapeutics
Publisher: Wiley
Published: 2001-12-27
Volume: 15
Issue: 12
Pages: 1989-1999
ISSN: 0269-2813 (ISSN-L)
1365-2036
DOI: 10.1046/j.1365-2036.2001.01113.x
OpenAlex: W2055562038
Cited by: 169
References: 47
Citations by year: 2026: 1 · 2025: 4 · 2024: 4 · 2023: 10 · 2022: 12 · 2021: 10 · 2020: 8 · 2019: 8 · 2018: 5 · 2017: 6 · 2016: 11 · 2015: 10 · 2014: 10 · 2013: 8 · 2012: 4
FWCI: 2.00
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 61 d)
Locations: Alimentary Pharmacology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
Funders: Crohn's and Colitis Foundation
Crohn's and Colitis Foundation of Canada
Medical Research Council
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: oral iron supplementation, ulcerative colitis, DSS-induced colitis, oxidative stress, colonic inflammation, lipid peroxidation, Fenton reaction, reactive oxygen species, antioxidant vitamins, glutathione peroxidase, iron bioavailability, dose-dependent effects
MeSH terms: Administration, Oral, Animals, Antioxidants, Ascorbic Acid, Colitis, Disease Models, Animal, Drug Interactions, Glutathione Peroxidase, Inflammation, Intestines, Iron, Male, Mucous Membrane, Vitamin E, Lipid Peroxidation, Dextran Sulfate, Rats, Wistar, Reactive Oxygen Species, Oxidative Stress, Dietary Supplements, Rats, In Vitro Techniques

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Effect of oral iron supplementation on oxidative stress and colonic inflammation in rats with induced colitis

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