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Effect of oral iron supplementation on oxidative stress and colonic inflammation in rats with induced colitis
Open accessAbstract
BACKGROUND: Iron supplementation may increase disease activity in ulcerative colitis, possibly through the production of reactive oxygen species from the Fenton reaction. AIM: To assess the effects of two doses of oral iron on intestinal inflammation and oxidative stress in experimental colitis. METHODS: Colitis was induced in rats by giving 5% dextran sulphate sodium in drinking water for 7 days. First, using a 2 x 2 factorial design, rats with or without dextran sulphate sodium received the regular diet or a diet containing iron 3%/kg diet. Second, rats with dextran sulphate sodium-induced colitis were supplemented with iron 0.3%/kg diet and compared with rats on dextran sulphate sodium and regular diet. The body weight change, histological scores, colon length, rectal bleeding, plasma and colonic lipid peroxides, colonic glutathione peroxidase and plasma vitamin E and C were measured. Faecal analysis for haem and total, free and ethylenediaminetetra-acetic acid-chelatable iron was also performed. RESULTS: Iron 3% and iron 0.3% increased the activity of dextran sulphate sodium-induced colitis, as demonstrated by higher histological scores, heavier rectal bleeding and further shortening of the colon. This was associated with increased lipid peroxidation and decreased antioxidant vitamins. Faecal iron available to the Fenton reaction was increased in a dose-dependent manner. CONCLUSIONS: Iron supplementation taken orally enhanced the activity of dextran sulphate sodium-induced colitis and is associated with an increase in oxidative stress.
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“In subjects with a genetic predisposition both, a shift of the microbiome towards colitogenic taxa by iron and the disturbance of immune tolerance mechanisms, may contribute to the manifestation of inflammatory bowel disease such as Crohn's disease and ulcerative colitis (Carrier et al., 2001(Carrier et al., , 2006;;Chua et al., 2013).”
From Iron in infection and immunity (2020) · cites this paper as Carrier et al., 2001
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Metadata
- Authors
- Carrier, J., Aghdassi, E., Platt, I., Cullen, J., & Allard, J. P.
- Affiliations
- University of Toronto (CA)
- St Joseph's Health Centre (CA)
- Corresponding author
- Allard, J. P.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2001-12-27
- Volume
- 15
- Issue
- 12
- Pages
- 1989-1999
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W2055562038
- Cited by
- 169
- References
- 47
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 10 · 2022: 12 · 2021: 10 · 2020: 8 · 2019: 8 · 2018: 5 · 2017: 6 · 2016: 11 · 2015: 10 · 2014: 10 · 2013: 8 · 2012: 4
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Alimentary Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Crohn's and Colitis Foundation
- Crohn's and Colitis Foundation of Canada
- Medical Research Council
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- oral iron supplementation, ulcerative colitis, DSS-induced colitis, oxidative stress, colonic inflammation, lipid peroxidation, Fenton reaction, reactive oxygen species, antioxidant vitamins, glutathione peroxidase, iron bioavailability, dose-dependent effects
- MeSH terms
- Administration, Oral, Animals, Antioxidants, Ascorbic Acid, Colitis, Disease Models, Animal, Drug Interactions, Glutathione Peroxidase, Inflammation, Intestines, Iron, Male, Mucous Membrane, Vitamin E, Lipid Peroxidation, Dextran Sulfate, Rats, Wistar, Reactive Oxygen Species, Oxidative Stress, Dietary Supplements, Rats, In Vitro Techniques
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