The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Oral desensitizing treatment in food allergy: clinical and immunological results
Abstract
Summary: Background : The possibility of inducing oral desensitization in patients with food allergy is still controversial and no standardized programmes are yet available. Aim : To evaluate the safety and efficacy of oral desensitization in patients with allergy induced by the most common food allergens. Methods : Fifty‐nine patients with food allergy underwent an oral desensitizing treatment according to standardized protocols. The control group consisted of age‐ and sex‐matched subjects, who followed a strict elimination diet. Specific immunoglobulin E and immunoglobulin G 4 were assessed at baseline and after 6, 12 and 18 months. Results : The majority of patients (83.3%) successfully completed the treatment. During treatment, 51.1% of subjects experienced some mild side‐effects, easily controlled by the oral administration of antihistamines or sodium cromolyn. Specific immunoglobulin E showed a significant decrease, whilst specific immunoglobulin G 4 showed a significant increase in all patients. Conclusions : The immunological findings induced by oral desensitization in food allergy allow us to hypothesize that oral tolerance may be mediated by the same mechanisms as those involved in traditional desensitizing treatments for respiratory allergies. Moreover, the proposed standardized oral desensitization protocols may represent an effective alternative approach in the management of food‐allergic patients.
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Cites
Allergen Immunotherapy: Therapeutic Vaccines for Allergic Diseases
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Self-citationOral rush desensitization to milk
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Cited by
Allergen immunotherapy: A practice parameter third update
Cox, L., Nelson, H., Lockey, R., Calabria, C., Chacko, T., Finegold, I., Nelson, M., Weber, R., Bernstein, D. I., Blessing-Moore, J., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.09.034 · Cited by 1,256
Clinical efficacy and immune regulation with peanut oral immunotherapy
Jones, S. M., Pons, L., Roberts, J. L., Scurlock, A. M., Perry, T. T., Kulis, M., Shreffler, W. G., Steele, P., Henry, K. A., Adair, M., et al. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.05.022 · Cited by 715
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EAACI Guidelines on allergen immunotherapy: IgE‐mediated food allergy
Pajno, G. B., Fernandez‐Rivas, M., Arasi, S., Roberts, G., Akdis, C. A., Alvaro‐Lozano, M., Beyer, K., Bindslev‐Jensen, C., Burks, W., Ebisawa, M., et al. (2018) · Allergy · doi:10.1111/all.13319 · Cited by 566
Staden, U., Rolinck‐Werninghaus, C., Brewe, F., Wahn, U., Niggemann, B., & Beyer, K. (2007) · Allergy · doi:10.1111/j.1398-9995.2007.01501.x · Cited by 466
Metadata
- Authors
- Patriarca, G., Nucera, E., Roncallo, C., Pollastrini, E., Bartolozzi, F., De Pasquale, T., Buonomo, A., Gasbarrini, G., Di Campli, C., & Schiavino, D.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2003-02
- Volume
- 17
- Issue
- 3
- Pages
- 459-465
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W1525120429
- Cited by
- 303
- References
- 10
- FWCI
- 4.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Patriarca, G., Nucera, E., Roncallo, C., Pollastrini, E., Bartolozzi, F., De Pasquale, T., Buonomo, A., Gasbarrini, G., Di Campli, C., & Schiavino, D. (2003). Oral desensitizing treatment in food allergy: clinical and immunological results. Alimentary Pharmacology & Therapeutics. https://doi.org/10.1046/j.1365-2036.2003.01468.x
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