The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.
Alpha‐2 and imidazoline receptor agonistsTheir pharmacology and therapeutic role
Abstract
Clonidine has proved to be a clinically useful adjunct in clinical anaesthetic practice as well as in chronic pain therapy because it has both anaesthetic and analgesic‐sparing activity. The more selective alpha‐2 adrenoceptor agonists, dexmedetomidine and mivazerol, may also have a role in providing haemodynamic stability in patients who are at risk of peri‐operative ischaemia. The side‐effects of hypotension and bradycardia have limited the routine use of alpha‐2 adrenoceptor agonists. Investigations into the molecular pharmacology of alpha‐2 adrenoceptors have elucidated their role in the control of wakefulness, blood pressure and antinociception. We discuss the pharmacology of alpha‐2 adrenoceptors and their therapeutic role in this review. The alpha‐2 adrenoceptor agonists are agonists at imidazoline receptors which are involved in central blood pressure control. Selective imidazoline agonists are now available for clinical use as antihypertensive agents and their pharmacology is discussed.
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Cites
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Phytocannabinoids: a unified critical inventory
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NEW AGENTS FOR SEDATION IN THE INTENSIVE CARE UNIT
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Tham, S. M., Angus, J. A., Tudor, E. M., & Wright, C. E. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706045 · Cited by 98
Metadata
- Authors
- Khan, Z. P., Ferguson, C. N., & Jones, R. M.
- Venue
- Anaesthesia
- Publisher
- Wiley
- Published
- 1999-02
- Volume
- 54
- Issue
- 2
- Pages
- 146-165
- ISSN
- 0003-2409 (ISSN-L)
- 1365-2044
- OpenAlex
- W1851466778
- Cited by
- 686
- References
- 114
- FWCI
- 17.97
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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