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Cited by 171Pharmacovigilance and Adverse Drug ReactionsTreatment of Major DepressionElectroconvulsive Therapy Studies

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

A comparison of the post‐marketing safety of four selective serotonin re‐uptake inhibitors including the investigation of symptoms occurring on withdrawal

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PRICE, JOHN S., WALLER, PATRICK C., WOOD, SUSAN M., MACKAY, ANGUS V. P.·1996·British Journal of Clinical Pharmacology
DOI 10.1046/j.1365-2125.1996.00498.xPMC PMC2042719
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Abstract

1 We have addressed the question of whether there is a ‘serotonin withdrawal syndrome’ by analysis of spontaneous reports of suspected adverse drug reactions (ADRs) associated with four SSRIs. A comparison of the post‐marketing safety profiles of the four SSRIs has also been made. 2 The UK database of ADRs was examined for reactions associated with fluoxetine, fluvoxamine, paroxetine and sertraline. The safety profiles of the four SSRIs were similar. However, withdrawal reactions with paroxetine constitute a greater proportion of reports (5.1%) than with the other SSRIs (0.06–0.9%). They have been reported more often with paroxetine (0.3 reports per thousand prescriptions) than with sertraline and fluvoxamine (0.03), and least often with fluoxetine (0.002). 3 Descriptions of withdrawal reactions received and further details of 217 reports of withdrawal reaction with paroxetine obtained by mailing a questionnaire to the reporting doctor were examined. Withdrawal symptoms were diverse but most commonly comprised dizziness, paraesthesia, tremor, anxiety, nausea and palpitation. They usually occurred after 2 days and lasted for an average of 10 days. There was no evidence of a physical drug dependency syndrome. 4 Symptoms different from the previous depressive illness occur after discontinuing an SSRI, and are reported most often with paroxetine. Paroxetine is the most pharmacologically specific of the SSRIs, but it is not clear whether the reactions constitute a ‘serotonin withdrawal syndrome’.

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Research works printed but not linked: 2

  1. [1]1. Borg S, Brodin K. Antidepressants. In Meyler's Side Effects 17 Szabadi E. Fluvoxamine withdrawal syndrome. Br J Psychiat 1992; 160: 283-284.
  2. [2]2. of Drugs, 12th edition, ed. Dukes MNG, Elsevier, 1992: 30-78.

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Metadata

Authors
PRICE, J. S., WALLER, P. C., WOOD, S. M., & MACKAY, A. V. P.
Affiliations
Government of the United Kingdom (GB)
ORCID
WOOD, SUSAN M.
Venue
British Journal of Clinical Pharmacology
Publisher
Wiley
Published
1996-12
Volume
42
Issue
6
Pages
757-763
ISSN
  • 0306-5251 (ISSN-L)
  • 1365-2125
DOI
10.1046/j.1365-2125.1996.00498.x
PMC
PMC2042719
OpenAlex
W2078302667
Semantic Scholar
046ede5f171a0a448e731c5a44baf73198becfd9
Cited by
171
References
3
Citations by year
2026: 1 · 2024: 6 · 2023: 1 · 2022: 5 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 3 · 2015: 3 · 2014: 3 · 2013: 7 · 2012: 7
FWCI
20.42
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2496 d)
Locations
  • British Journal of Clinical Pharmacology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
Keywords
selective serotonin reuptake inhibitors, paroxetine, fluoxetine, fluvoxamine, sertraline, adverse drug reactions, post-marketing safety, spontaneous adverse event reporting, drug addiction
MeSH terms
Adult, Female, Fluoxetine, Humans, Male, Product Surveillance, Postmarketing, Substance Withdrawal Syndrome, 1-Naphthylamine, Fluvoxamine, Selective Serotonin Reuptake Inhibitors, Paroxetine, Sertraline

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