The DOI matches its Crossref record.
Adverse drug reactions and off-label drug use in paediatric outpatients
Open accessAbstract
AIMS: To investigate the potential relationship between off-label drug use and increased risk of adverse drug reactions in paediatric outpatients. METHODS: A prospective pharmacovigilance survey of drug prescribing in office based paediatricians was carried out in Haute-Garonne County (south west of France). RESULTS: The study involved a sample of 1419 children under 16 years old. Forty-two percent of patients were exposed to at least one off-label prescription. The incidence of adverse drug reactions was 1.41% (95% CI 0.79, 2.11). Off-label drug use was significantly associated with adverse drug reactions (relative risk 3.44; 95% CI 1.26, 9.38), particularly when it was due to an indication different than that defined in the Summary Product Characteristics (relative risk 4.42; 95% CI 1.60, 12.25). CONCLUSIONS: Our data suggest an increasing risk of adverse drug reactions related to off-label drug use. This risk would be acceptable if further studies prove the potential benefit of such a drug use.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Development and Evaluation of a Generic Physiologically Based Pharmacokinetic Model for Children
Edginton, A. N., Schmitt, W., & Willmann, S. (2006) · Clinical Pharmacokinetics · doi:10.2165/00003088-200645100-00005 · Cited by 357
A literature review on off-label drug use in children
Pandolfini, C., & Bonati, M. (2005) · European Journal of Pediatrics · doi:10.1007/s00431-005-1698-8 · Cited by 346
Medication Use in the Neonatal Intensive Care Unit
Hsieh, E., Hornik, C., Clark, R., Laughon, M., Benjamin, D., Smith, P., & on Behalf of the Best Pharmaceuticals for Children Act—Pediatric Trials Network (2013) · American Journal of Perinatology · doi:10.1055/s-0033-1361933 · Cited by 318
Bellis, J. R., Kirkham, J. J., Nunn, A. J., & Pirmohamed, M. (2014) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12222 · Cited by 120
Metadata
- Authors
- Horen, B., Montastruc, J.-L., & Lapeyre-Mestre, M.
- Venue
- British Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 2002-12
- Volume
- 54
- Issue
- 6
- Pages
- 665-670
- ISSN
- 0306-5251 (ISSN-L)
- 1365-2125
- OpenAlex
- W1984710954
- Cited by
- 294
- References
- 0
- FWCI
- 9.41
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Adverse drug reactions and off-label drug use in paediatric outpatients. https://app.cochat.ai/papers/10.1046/j.1365-2125.2002.t01-3-01689.x
- The paper
- Horen, B., Montastruc, J.-L., & Lapeyre-Mestre, M. (2002). Adverse drug reactions and off-label drug use in paediatric outpatients. British Journal of Clinical Pharmacology. https://doi.org/10.1046/j.1365-2125.2002.t01-3-01689.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
