The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
MMR vaccine and idiopathic thrombocytopaenic purpura
Open accessAbstract
AIMS: To estimate the relationship between idiopathic thrombocytopaenic purpura (ITP) and the measles, mumps and rubella (MMR) vaccination in children; calculating the relative risk estimate for ITP with in 6 weeks after MMR vaccination and the attributable risk of ITP within 6 weeks after MMR vaccination. METHODS: Using the General Practice Research Database we identified children with a first-time diagnosis of ITP from a base population of children aged less than 6 years between January 1988 and December 1999. After describing the characteristics of all the children identified with ITP, we focused on cases aged 13-24 months to perform a population-based, case-control analysis to estimate the relative risk of developing ITP within 6 weeks after MMR vaccination. We also calculated the risk of ITP attributable to the MMR vaccination. RESULTS: Sixty-three children with a first time diagnosis of ITP were identified; 23 cases were between 13 and 24 months old. The relative risk estimate for ITP within 6 weeks after MMR vaccination, compared to the combined group of unvaccinated children and children vaccinated with MMR more than 26 weeks previously was 6.3 (95% CI 1.3-30.1). The attributable risk of developing ITP within 6 weeks after MMR vaccination was estimated to be 1 in 25,000 vaccinations (95% confidence interval 21,300, 89,400). CONCLUSION: This study confirms the increased risk of ITP within 6 weeks after MMR vaccination. However, the attributable risk of ITP within 6 weeks after MMR vaccination is low.
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“Lack of clarity over the vaccine exposure status of the controls made the results of the Black 2003 study difficult to interpret.”
From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Black 2003
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“Moderate/unknown risk of bias: eight studies (Black 2003; Bremner 2005; Bremner 2007; DeStefano 2004; Ma 2005; Mrozek-Budzyn 2010; Ray 2006; Smeeth 2004).”
From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Black 2003
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Risk of Immune Thrombocytopenic Purpura Recurrence Following Second Measles-Containing Vaccine Dose
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“In children the estimated relative risk of developing ITP in the six weeks following vaccination was found to be be-tween 2.14 and 6.3 (Bertuola et al., 2010; Black et al., 2003; Cecinati et al., 2013; Miller et al., 2001).”
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Metadata
- Authors
- Black, C., Kaye, J. A., & Jick, H.
- Affiliations
- Boston University (US)
- Corresponding author
- Black, Corri
- Venue
- British Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 2003-01
- Volume
- 55
- Issue
- 1
- Pages
- 107-111
- ISSN
- 0306-5251 (ISSN-L)
- 1365-2125
- PMC
- PMC1884189
- OpenAlex
- W1486224385
- Cited by
- 137
- References
- 14
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 8 · 2023: 2 · 2022: 10 · 2021: 17 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 6 · 2016: 5 · 2015: 7 · 2014: 4 · 2013: 5 · 2012: 6
- FWCI
- 1.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Clinical Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bristol-Myers Squibb
- AstraZeneca
- GlaxoSmithKline
- Novartis Farmacéutica
- Topics
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Health Sciences › Medicine › Hematology › Heparin-Induced Thrombocytopenia and Thrombosis
- Keywords
- MMR vaccine, measles-mumps-rubella vaccination, vaccine adverse events, children, relative risk, attributable risk
- MeSH terms
- Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Risk Factors, Case-Control Studies, Purpura, Thrombocytopenic, Idiopathic, Measles-Mumps-Rubella Vaccine
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