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Cited by 1,874

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Age‐related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications

Open access
Mangoni, A. A., Jackson, S. H. D.·2004·British Journal of Clinical Pharmacology
DOI 10.1046/j.1365-2125.2003.02007.x
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Abstract

Advancing age is characterized by impairment in the function of the many regulatory processes that provide functional integration between cells and organs. Therefore, there may be a failure to maintain homeostasis under conditions of physiological stress. The reduced homeostatic ability affects different regulatory systems in different subjects, thus explaining at least partly the increased interindividual variability occurring as people get older. Important pharmacokinetic and pharmacodynamic changes occur with advancing age. Pharmacokinetic changes include a reduction in renal and hepatic clearance and an increase in volume of distribution of lipid soluble drugs (hence prolongation of elimination half‐life) whereas pharmacodynamic changes involve altered (usually increased) sensitivity to several classes of drugs such as anticoagulants, cardiovascular and psychotropic drugs. This review focuses on the main age‐related physiological changes affecting different organ systems and their implications for pharmacokinetics and pharmacodynamics of drugs.

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Metadata

Authors
Mangoni, A. A., & Jackson, S. H. D.
Venue
British Journal of Clinical Pharmacology
Publisher
Wiley
Published
2003-12-16
Volume
57
Issue
1
Pages
6-14
ISSN
  • 0306-5251 (ISSN-L)
  • 1365-2125
DOI
10.1046/j.1365-2125.2003.02007.x
OpenAlex
W2149485684
Cited by
1,874
References
5
FWCI
6.66
Type
journal article
Language
en
Open access
green

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.