Increased sensitivity to nitrazepam in old age
Open accessAbstract
The effects of a single 10 mg oral dose of nitrazepam were compared with those of a placebo in healthy young and old people. Both the young and the elderly slept better on three successive nights after nitrazepam but they felt less awake at 12 and 36 hours (P less than 0-01). Elderly people made significantly more mistakes in a psychomotor test than did the young, despite similar plasma concentrations of nitrazepam and half lives in the two groups. This difference in response to psychomotor testing is probably explained by an increased sensitivity of the ageing brain to the action of nitrazepam.
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Benzodiazepine pharmacologic effects appear greater in elderly patients than in younger patients even at similar plasma concentrations, possibly because of age-related changes in drug-receptor interactions, post-receptor mechanisms, and organ function.
“Furthermore, BZD pharmacologic effects appear to be greater in elderly patients than in younger patients even at similar plasma BZD concentrations (63,64), possibly because of age-related changes in drug-receptor interactions, post-receptor mechanisms and organ function.”
From Benzodiazepines in epilepsy: Pharmacology and pharmacokinetics (2008) · cites this paper as [63]
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- Authors
- Castleden, C. M., George, C. F., Marcer, D., & Hallett, C.
- Affiliations
- Aristotle University of Thessaloniki (GR)
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1977-01-01
- Volume
- 1
- Issue
- 6052
- Pages
- 10-12
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- OpenAlex
- W2021641960
- Cited by
- 320
- References
- 14
- Citations by year
- 2024: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 2 · 2015: 1 · 2012: 3
- FWCI
- 30.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- nitrazepam, age-related drug sensitivity, older adults, hypnotics, sleep quality, psychomotor performance, cognitive impairment, plasma drug concentration, brain aging
- MeSH terms
- Adult, Age Factors, Aged, Clinical Trials as Topic, Dose-Response Relationship, Drug, Female, Humans, Male, Motor Skills, Nitrazepam
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