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Cited by 82Nail Diseases and TreatmentsDermatology and Skin DiseasesFungal Infections and Studies

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Seborrhoeic dermatitis is not caused by an altered immune response to Malassezia yeast: MALASSEZIA IMMUNITY IN SEBORRHOEIC DERMATITIS

Parry, Sharpe·1998·British Journal of Dermatology
DOI 10.1046/j.1365-2133.1998.02362.x
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Abstract

The immune response of patients with seborrhoeic dermatitis and healthy age- and sex-matched controls was examined to test the hypothesis that an inadequate or inappropriate immune response to Malassezia yeast leads to seborrhoeic dermatitis. Antibody responses were examined using enzyme-linked immunosorbent assays (ELISAs) and Western blots and lymphocyte responses using lymphocyte proliferation assays. The level of IgG and IgM specific for whole yeast cells or extracted proteins of two isolates of M. furfur was tested in ELISA. A wide range of antibody levels was found but the patient and control groups were indistinguishable (n = 19), and the groups could not be distinguished by the pattern of Malassezia proteins recognized by their sera in Western blots. The average affinity of the subjects' antibodies specific for Malassezia cells or proteins was measured using ammonium thiocyanate dissociation. Most of the sera had moderate affinities corresponding to 50% dissociation at thiocyanate concentrations of 0.5-1.0 mol/L. There was no difference between patients and matched controls. The proliferation of the patients' lymphocytes in response to a number of M. furfur cell preparations was measured: whole cells, cytoplasmic proteins, cell walls, soluble molecules extracted from the cell walls using sonication, and a commercial preparation. There was a wide range of responses between individuals, but there was no difference between the three groups: patients with seborrhoeic dermatitis (n = 16), healthy controls (n = 16) and a group suffering from other inflammatory skin conditions (n = 15). The results do not support the hypothesis that an inadequate immune response to Malassezia yeast could lead to seborrhoeic dermatitis. Other possible pathological mechanisms include toxin production or lipase activity.

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Crossref · 10.1046/j.1365-2133.1998.02362.x

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  • No increase in the titers of antibodies against Malassezia was detected in SD patients, suggesting that the elevated immunoglobulin production occurs as a response to yeast metabolites.

    “However, no increase in the titers of antibodies against Malassezia was detected, suggesting that the elevated immunoglobulin production occurs rather as a response to yeast metabolites [26,75,76].”

    From Seborrheic Dermatitis and Dandruff: A Comprehensive Review (2015) · cites this paper as [76]

  • The lack of increase in anti-Malassezia antibodies indicates a change in cellular immune response instead of humoral response.

    “The lack of increase in anti-Malassezia antibodies also indicates a change in cellular immune response instead of humoral response [76,77].”

    From Seborrheic Dermatitis and Dandruff: A Comprehensive Review (2015) · cites this paper as [76]

Citations

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Research works printed but not linked: 38

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Metadata

Authors
Parry, & Sharpe
Affiliations
University of Liverpool (GB)
Corresponding author
Sharpe
Venue
British Journal of Dermatology
Publisher
Oxford University Press (OUP)
Published
1998-08
Volume
139
Issue
2
Pages
254-263
ISSN
0007-0963 (ISSN-L)
DOI
10.1046/j.1365-2133.1998.02362.x
OpenAlex
W2131243653
Cited by
82
References
1
Citations by year
2025: 2 · 2023: 2 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 6 · 2014: 1 · 2013: 1 · 2012: 3
FWCI
3.12
Type
journal article
Language
en
Open access
closed
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 6240 d)
Locations
  • British Journal of Dermatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Nail Diseases and Treatments
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
Keywords
seborrheic dermatitis, Malassezia furfur, immune response, antibody response, lymphocyte proliferation, IgG, IgM, antibody affinity, inflammatory skin diseases, pathogenesis
MeSH terms
Adult, Antibodies, Fungal, Antibody Affinity, Antigens, Fungal, Cell Division, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunoglobulin G, Immunoglobulin M, Lymphocytes, Malassezia, Male, Middle Aged, Dermatitis, Seborrheic, Blotting, Western

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