Cited by 187Essential Oils and Antimicrobial ActivityDermatology and Skin DiseasesContact Dermatitis and Allergies

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Tea tree oil reduces histamine-induced skin inflammation

Koh, K.J., Pearce, A.L., Marshman, G., Finlay-Jones, J.J., Hart, P.H.·2002·British Journal of Dermatology

DOI 10.1046/j.1365-2133.2002.05034.x

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Abstract

BACKGROUND: Tea tree oil is the essential oil steam-distilled from Melaleuca alternifolia, an Australian native plant. In recent years it has become increasingly popular as an antimicrobial for the treatment of conditions such as tinea pedis and acne. OBJECTIVES: To investigate the anti-inflammatory properties of tea tree oil on histamine-induced weal and flare. METHODS: Twenty-seven volunteers were injected intradermally in each forearm (study and control assigned on an alternating basis) with histamine diphosphate (5 microg in 50 microL). Flare and weal diameters and double skin thickness were measured every 10 min for 1 h to calculate flare area and weal volume. At 20 min, 25 microL of 100% tea tree oil was applied topically to the study forearm of 21 volunteers. For six volunteers, 25 microL paraffin oil was applied instead of tea tree oil. RESULTS: Application of liquid paraffin had no significant effect on histamine-induced weal and flare. There was also no difference in mean flare area between control arms and those on which tea tree oil was applied. However, mean weal volume significantly decreased after tea tree oil application (10 min after tea tree oil application, P = 0.0004, Mann-Whitney U-test). CONCLUSIONS: This is the first study to show experimentally that tea tree oil can reduce histamine-induced skin inflammation.

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Authors: Koh, K. J., Pearce, A. L., Marshman, G., Finlay-Jones, J. J., & Hart, P. H.
Affiliations: Flinders Medical Centre (AU)
Flinders University (AU)
Corresponding author: Hart, P.H.
ORCID: Marshman, G.
Hart, P.H.
Venue: British Journal of Dermatology
Publisher: Oxford University Press (OUP)
Published: 2002-12
Volume: 147
Issue: 6
Pages: 1212-1217
ISSN: 0007-0963 (ISSN-L)
1365-2133
DOI: 10.1046/j.1365-2133.2002.05034.x
OpenAlex: W2070662166
Cited by: 185
References: 13
Citations by year: 2026: 1 · 2025: 5 · 2024: 17 · 2023: 14 · 2022: 7 · 2021: 17 · 2020: 14 · 2019: 6 · 2018: 11 · 2017: 5 · 2016: 9 · 2015: 4 · 2014: 9 · 2013: 8 · 2012: 9
FWCI: 8.48
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 4657 d)
Locations: British Journal of Dermatology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
Keywords: tea tree oil, Melaleuca alternifolia, anti-inflammatory activity, topical application, skin thickness, essential oils
MeSH terms: Adult, Anti-Inflammatory Agents, Non-Steroidal, Dermatitis, Atopic, Female, Histamine, Humans, Injections, Intradermal, Male, Phytotherapy, Middle Aged, Case-Control Studies, Tea Tree Oil

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Tea tree oil reduces histamine-induced skin inflammation

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