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Humanized CD52 monoclonal antibody campath‐1H as first‐line treatment in chronic lymphocytic leukaemia
Abstract
The humanized CD52 monoclonal antibody Campath‐1H was used as first‐line therapy in nine patients with progressive chronic lymphocytic leukaemia (CLL). Intravenous (n = 5) or subcutaneous (n = 4) injections (up to 30 mg/inj.) were given three times a week for a maximum of 18 weeks. Three patients achieved a complete remission (CR) and five patients a partial remission (PR) (response rate 89%). CLL cells were cleared from blood in all patients and from the bone marrow in seven patients. The response duration time was 8+–24+ months. Adverse events were mild except for one patient who developed CMV pneumonitis. All patients developed lymphocytopenia (B and T cells) but other haematological toxicities were negligible. Campath‐1H is a highly effective and well‐tolerated agent in patients with previously untreated CLL and further studies are warranted.
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Cited by
Winkler, U., Jensen, M., Manzke, O., Schulz, H., Diehl, V., & Engert, A. (1999) · Blood · doi:10.1182/blood.v94.7.2217.419k02_2217_2224 · Cited by 657
Osterborg, A., Dyer, M. J., Bunjes, D., Pangalis, G. A., Bastion, Y., Catovsky, D., & Mellstedt, H. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.4.1567 · Cited by 512
Self-citationLundin, J., Kimby, E., Björkholm, M., Broliden, P.-A., Celsing, F., Hjalmar, V., Möllgård, L., Rebello, P., Hale, G., Waldmann, H., et al. (2002) · Blood · doi:10.1182/blood-2002-01-0159 · Cited by 497
Self-citationLundin, J., Porwit-MacDonald, A., Rossmann, E. D., Karlsson, C., Edman, P., Rezvany, M. R., Kimby, E., Österborg, A., & Mellstedt, H. (2004) · Leukemia · doi:10.1038/sj.leu.2403258 · Cited by 118
Self-citationWarner, J. L., & Arnason, J. E. (2012) · Therapeutic Advances in Hematology · doi:10.1177/2040620712458949 · Cited by 31
Metadata
- Authors
- ÖSterborg, A., Fassas, A. S., Anagnostopoulos, A., Dyer, M. J. S., Catovsky, D., & Mellstedt, H.
- Venue
- British Journal of Haematology
- Publisher
- Wiley
- Published
- 1996-04
- Volume
- 93
- Issue
- 1
- Pages
- 151-153
- ISSN
- 0007-1048 (ISSN-L)
- 1365-2141
- OpenAlex
- W2061365129
- Cited by
- 228
- References
- 0
- FWCI
- 6.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Humanized CD52 monoclonal antibody campath‐1H as first‐line treatment in chronic lymphocytic leukaemia. https://app.cochat.ai/papers/10.1046/j.1365-2141.1996.450989.x
- The paper
- ÖSterborg, A., Fassas, A. S., Anagnostopoulos, A., Dyer, M. J. S., Catovsky, D., & Mellstedt, H. (1996). Humanized CD52 monoclonal antibody campath‐1H as first‐line treatment in chronic lymphocytic leukaemia. British Journal of Haematology. https://doi.org/10.1046/j.1365-2141.1996.450989.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
