Cited by 31Chronic Lymphocytic Leukemia ResearchLymphoma Diagnosis and TreatmentAcute Lymphoblastic Leukemia research

Alemtuzumab use in relapsed and refractory chronic lymphocytic leukemia: a history and discussion of future rational use

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Warner, Jeremy L., Arnason, Jon E.·2012·Therapeutic Advances in Hematology

Abstract

In this review, we outline the clinical experience with single-agent alemtuzumab as a treatment for relapsed and refractory chronic lymphocytic leukemia (CLL) in both prospective and retrospective trials and describe the multiagent use of the drug with the goal of updating clinicians on recent developments and possible future rational combinations. Alemtuzumab, an antibody targeting the lymphocyte-specific surface marker CD52, is an approved agent for the treatment of CLL. Despite its demonstrated efficacy, likely secondary to concerns regarding infectious complications, it is most commonly used in the relapsed and refractory setting. Given alemtuzumab’s unique mechanism of action it has been demonstrated to have activity in disease that is refractory to both alkylating agents and purine analogs. Furthermore, it has activity in TP53-mutated disease, which has the worst prognosis of any subset of CLL. Alemtuzumab has greater efficacy on circulating disease relative to nodal disease. Rational combinations are attempting to use these attributes to increase response rates in patients with relapsed and refractory disease.

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  • Small pilot studies using subcutaneous infusion reported that immediate flu-like toxicities associated with intravenous treatment were less severe when using the subcutaneous route of administration.

    “Small pilot studies using subcutaneous infusion reported that immediate flu-like toxicities associated with intravenous treatment were less severe when using the subcutaneous route of administration [80].”

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  1. Albo C., Perez-Encinas M., Lavilla E., Dios A., Plaza J., Simiele A., et al. (2007) Incidence and spectrum of infection in patients treated with alemtuzumab: a multicenter experience, 12th Congress of the European Hematology Association. Haematologica 92(Suppl. 1): abstract 1036 [Google Scholar]
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Authors
Warner, J. L., & Arnason, J. E.
Affiliations
Beth Israel Deaconess Medical Center (US)
Venue
Therapeutic Advances in Hematology
Published
2012-08-31
Volume
3
Issue
6
Pages
375-389
ISSN
  • 2040-6207 (ISSN-L)
  • 2040-6215
OpenAlex
W2147947917
Cited by
31
References
102
Citations by year
2026: 1 · 2025: 4 · 2024: 4 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 2
FWCI
0.76
Type
journal article
Language
en
Open access
Locations
  • Therapeutic Advances in Hematology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Genetics › Chronic Lymphocytic Leukemia Research
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
Keywords
alemtuzumab, CD52, monoclonal antibody therapy, TP53 mutation, combination therapy, infectious complications

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