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Cited by 151Drug-Induced Adverse ReactionsFood Allergy and Anaphylaxis ResearchContact Dermatitis and Allergies

Lack of allergic cross-reactivity to cephalosporins among patients allergic to penicillins.

Novalbos, A., Sastre, J., Cuesta, J., De Las Heras, M., Lluch‐Bernal, M., Bombín, C., Quirce, S.·2001·Clinical & Experimental Allergy
DOI 10.1046/j.1365-2222.2001.00992.x
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Abstract

There are some contradicting data about clinical allergic cross-reactivity to cephalosporins among patients who have had a previous allergic reaction to penicillins. The purpose of this study was to assess the safety of administering cephalosporins to penicillin-allergic patients. The diagnosis of penicillin allergy was made by positive skin tests to penicillin reagents and/or provocation tests with the penicillin suspected of causing the allergic reaction. To assess the clinical tolerance to cephalosporins, 41 well-characterized penicillin allergic patients diagnosed by positive skin tests and/or provocation tests were challenged with three cephalosporins that do not share the same side chain to the penicillin that induced the reactions: cephazoline, cefuroxime and ceftriaxone. Skin prick and intradermal tests with all cephalosporins tested were negative. All penicillin-allergic patients tolerated therapeutic doses of the three cephalosporins tested (cephazoline, cefuroxime and ceftriaxone) without any ill effect. These results indicate that the risk of suffering from an allergic reaction on administering cephalosporins to penicillin-allergic patients seems to be very low, provided that cephalosporins with a different side chain to the penicillin responsible for the allergic reaction are used.

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Crossref · 10.1046/j.1365-2222.2001.00992.x

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18 of 18 references verified0 citation errors · 0 not checkable

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  • Cross-sensitivity between ceftriaxone and penicillin can occur.

    “Cross-sensitivity between ceftriaxone and penicillin can occur”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [620]

  • The risk for penicillin cross-reactivity between third-generation cephalosporins is negligible.

    “the risk for penicillin cross-reactivity between third-generation cephalosporins is negligible (618–621)”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [620]

  • Allergic reactions with third-generation cephalosporins (e.g., ceftriaxone) are uncommon among persons with a history of penicillin allergy.

    “Allergic reactions with third-generation cephalosporins (e.g., ceftriaxone) are uncommon among persons with a history of penicillin allergy (620,631,658,896).”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [620]

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Authors
Novalbos, A., Sastre, J., Cuesta, J., De Las Heras, M., Lluch‐Bernal, M., Bombín, C., & Quirce, S.
Affiliations
  • Hospital Universitario Fundación Jiménez Díaz (ES)
  • Universidad Autónoma de Madrid (ES)
Corresponding author
Sastre, J.
ORCID
Venue
Clinical & Experimental Allergy
Publisher
Wiley
Published
2001-03
Volume
31
Issue
3
Pages
438-443
ISSN
  • 0954-7894 (ISSN-L)
  • 1365-2222
DOI
10.1046/j.1365-2222.2001.00992.x
OpenAlex
W2089908113
Cited by
151
References
18
Citations by year
2026: 4 · 2024: 2 · 2023: 3 · 2022: 8 · 2021: 7 · 2020: 9 · 2019: 11 · 2018: 3 · 2017: 6 · 2016: 5 · 2015: 6 · 2014: 5 · 2013: 6 · 2012: 2
FWCI
6.24
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 294 d)
Locations
  • Clinical & Experimental Allergy (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
  • Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
  • Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
Keywords
cephalosporin allergy, penicillin allergy, cefuroxime, ceftriaxone, drug tolerance, skin testing, provocation tests, antibiotic allergy
MeSH terms
Adult, Allergens, Cephalosporins, Cross Reactions, Drug Hypersensitivity, Female, Humans, Hypersensitivity, Male, Middle Aged, Penicillins

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