Cited by 281Allergic Rhinitis and SensitizationFood Allergy and Anaphylaxis ResearchAsthma and respiratory diseases

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Prevention of new sensitizations in monosensitized subjects submitted to specific immunotherapy or not. A retrospective study

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Purello‐D'Ambrosio, F., Gangemi, S., Merendino, R. A., Isola, S., Puccinelli, P., Parmiani, S., Ricciardi, L.·2001·Clinical & Experimental Allergy

DOI 10.1046/j.1365-2222.2001.01027.x

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Abstract

Background Specific immunotherapy is the only currently available allergen‐orientated treatment able to modify the natural history of respiratory allergic diseases. Safety and clinical efficacy of this treatment are well documented, but evidence about the ability to reduce new sensitizations is still poor. Objective We report a retrospective study conducted in order to assess the prevention of new sensitizations in monosensitized subjects treated with specific immunotherapy vs. monosensitized patients treated with anti‐allergic drugs. Methods 8396 monosensitized patients with respiratory symptoms were selected according to an open, retrospective design. Group A included 7182 patients submitted to specific immunotherapy (and anti‐allergic drugs when needed) for 4 years and then treated with drugs for at least 3 years. Group B included 1214 patients treated only with drugs for at least 7 years. All patients underwent prick test with a standard panel of allergens and total and specific IgE determination before and after 4 years of treatment and again 3 years later. Results Groups were well balanced. Polysensitized subjects were 23.75% in Group A and 68.03% in Group B after 4 years (P < 0.0001) and 26.95% and 76.77%, respectively, after 7 years (P < 0.0001). Asthmatic subjects were more prone to develop polysensitization in comparison to subjects suffering only from rhinitis (32.14% instead of 27.29% after 4 years, 36.5% instead of 31.33% after 7 years; P < 0.0001). Specific IgE decreased by 24.11% in Group A and increased by 23.87% in Group B (P < 0.0001). Total IgE decreased by 17.53% in Group A and increased by 13.71% in Group B (P < 0.0001). Conclusions Specific immunotherapy was observed retrospectively to reduce new sensitizations in monosensitized subjects suffering from respiratory allergic diseases.

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Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*
Bousquet, J., Khaltaev, N., Cruz, A. A., Denburg, J., Fokkens, W. J., Togias, A., Zuberbier, T., Baena‐Cagnani, C. E., Canonica, G. W., Van Weel, C., et al. (2008) · Allergy · doi:10.1111/j.1398-9995.2007.01620.x · Cited by 4,729
Expert Panel Report 2: Guidelines for the Diagnosis and Management of Asthma
Program, P., & theDiagnosis, T. E. P. O. (1997) · Cited by 4,082
British Guideline on the Management of Asthma
British Thoracic Society Scottish Intercollegiate Guidelines Network (2008) · Thorax · doi:10.1136/thx.2008.097741 · Cited by 2,023
Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 Revision
Brożek, J. L., Bousquet, J., Baena-Cagnani, C. E., Bonini, S., Canonica, G. W., Casale, T. B., van Wijk, R. G., Ohta, K., Zuberbier, T., & Schünemann, H. J. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.06.047 · Cited by 1,813
Allergen immunotherapy: A practice parameter third update
Cox, L., Nelson, H., Lockey, R., Calabria, C., Chacko, T., Finegold, I., Nelson, M., Weber, R., Bernstein, D. I., Blessing-Moore, J., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.09.034 · Cited by 1,256

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Authors: Purello‐D'Ambrosio, F., Gangemi, S., Merendino, R. A., Isola, S., Puccinelli, P., Parmiani, S., & Ricciardi, L.
Affiliations: University of Messina (IT)
ALK-Abelló (Italy) (IT)
Corresponding author: Gangemi, S.
ORCID: Gangemi, S.
Ricciardi, L.
Venue: Clinical & Experimental Allergy
Publisher: Wiley
Published: 2001-08
Volume: 31
Issue: 8
Pages: 1295-1302
ISSN: 0954-7894 (ISSN-L)
1365-2222
DOI: 10.1046/j.1365-2222.2001.01027.x
OpenAlex: W2085196853
Cited by: 281
References: 76
Citations by year: 2026: 1 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 4 · 2020: 5 · 2019: 6 · 2018: 12 · 2017: 13 · 2016: 16 · 2015: 14 · 2014: 17 · 2013: 9 · 2012: 14
FWCI: 5.74
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 164 d)
Locations: Clinical & Experimental Allergy (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Keywords: allergen immunotherapy, polysensitization, allergic respiratory diseases, asthma, allergic rhinitis, antiallergic drugs, specific IgE, total IgE, allergen sensitization
MeSH terms: Contraindications, Administration, Inhalation, Administration, Oral, Adult, Allergens, Epitopes, Asthma, Desensitization, Immunologic, Drug Administration Schedule, Female, Follow-Up Studies, Histamine H1 Antagonists, Humans, Hypersensitivity, Delayed, Immunoglobulin E, Italy, Male, Retrospective Studies, Rhinitis, Receptors, Adrenergic, beta-2, Anti-Allergic Agents, Adrenergic beta-2 Receptor Agonists

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Prevention of new sensitizations in monosensitized subjects submitted to specific immunotherapy or not. A retrospective study

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