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Prevention of new sensitizations in monosensitized subjects submitted to specific immunotherapy or not. A retrospective study
Open accessAbstract
Background Specific immunotherapy is the only currently available allergen‐orientated treatment able to modify the natural history of respiratory allergic diseases. Safety and clinical efficacy of this treatment are well documented, but evidence about the ability to reduce new sensitizations is still poor. Objective We report a retrospective study conducted in order to assess the prevention of new sensitizations in monosensitized subjects treated with specific immunotherapy vs. monosensitized patients treated with anti‐allergic drugs. Methods 8396 monosensitized patients with respiratory symptoms were selected according to an open, retrospective design. Group A included 7182 patients submitted to specific immunotherapy (and anti‐allergic drugs when needed) for 4 years and then treated with drugs for at least 3 years. Group B included 1214 patients treated only with drugs for at least 7 years. All patients underwent prick test with a standard panel of allergens and total and specific IgE determination before and after 4 years of treatment and again 3 years later. Results Groups were well balanced. Polysensitized subjects were 23.75% in Group A and 68.03% in Group B after 4 years (P < 0.0001) and 26.95% and 76.77%, respectively, after 7 years (P < 0.0001). Asthmatic subjects were more prone to develop polysensitization in comparison to subjects suffering only from rhinitis (32.14% instead of 27.29% after 4 years, 36.5% instead of 31.33% after 7 years; P < 0.0001). Specific IgE decreased by 24.11% in Group A and increased by 23.87% in Group B (P < 0.0001). Total IgE decreased by 17.53% in Group A and increased by 13.71% in Group B (P < 0.0001). Conclusions Specific immunotherapy was observed retrospectively to reduce new sensitizations in monosensitized subjects suffering from respiratory allergic diseases.
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“AIT is also thought to help halt the progression of allergic disease, including prevention of new allergic sensitivities and the development of asthma.1624,1626,1678,1797,1798,1824-1826”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [1626]
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Citations
Cites
Long-Term Clinical Efficacy of Grass-Pollen Immunotherapy
Durham, S. R., Walker, S. M., Varga, E., Jacobson, M. R., O'Brien, F., Noble, W. J., Till, S. J., Hamid, Q. A., & Nouri‐Aria, K. T. (1999) · New England Journal of Medicine · doi:10.1056/nejm199908123410702 · Cited by 1,371
PROPHYLACTIC INOCULATION AGAINST HAY FEVER
Noon, L. (1911) · The Lancet · doi:10.1016/s0140-6736(00)78276-6 · Cited by 1,343
Punnonen, J., Aversa, G., Cocks, B. G., McKenzie, A. N., Menon, S., Zurawski, G., Malefyt, R. D. W., & de Vries, J. E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.8.3730 · Cited by 1,101
Recombinant human interleukin 5 is a selective activator of human eosinophil function.
Lopez, A. F., Sanderson, C. J., Gamble, J. R., Campbell, H. D., Young, I., & Vadas, M. A. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.1.219 · Cited by 949
Allergen Immunotherapy: Therapeutic Vaccines for Allergic Diseases
Bousquet, J., Lockey, R. F., Malling, H., Álvarez-Cuesta, E., Canonica, G. W., Chapman, M. D., Creticos, P. S., Dayer, J., Durham, S. R., Demoly, P. M., et al. (1998) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)63136-5 · Cited by 739
Prete, G. D., Maggi, E., Parronchi, P., Chrétien, I., Tiri, A., Macchia, D., Ricci, M., Banchereau, J., de Vries, J. E., & Romagnani, S. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.12.4193 · Cited by 707
Roches, A. D., Paradis, L. P., Ménardo, J.-L., Bouges, S., Daurès, J., & Bousquet, J. (1997) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(97)70069-1 · Cited by 572
Interleukin 4 is localized to and released by human mast cells.
Bradding, P. H., Feather, I. H., Howarth, P. H., Mueller, R., Roberts, J. A., Britten, K. M., Bews, J. P. A., Hunt, T. C., Okayama, Y., & Heusser, C. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.5.1381 · Cited by 571
Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals.
Secrist, H., Chelen, C. J., Wen, Y., Marshall, J. D., & Umetsu, D. T. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.6.2123 · Cited by 539
von Mutius, E., Fritzsch, C., Weiland, S. K., Röll, G., & MAGNUSSEN, H. (1992) · BMJ · doi:10.1136/bmj.305.6866.1395 · Cited by 503
Research works printed but not linked: 4
- Jacobsen L, 1995, Proceedings of the XVI European Congress of Allergology and Clinical Immunology., 145
- D'Amato G, 1991, Variazioni antigeniche nei ceppi e nei lotti di Alternaria isolati in Ann Arbor e in Napoli, G Ital Allergol Immunol Clin, 1, 133
- Ebner C, 1997, a major grass pollen allergen, Clin Exp Allergy, 27, 1
- Des Roches A, 1995, Specific immunotherapy prevents the onset of new sensitizations in monosensitized children. [Abstract], J Allergy Clin Immunol, 95, 309
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Bousquet, J., Khaltaev, N., Cruz, A. A., Denburg, J., Fokkens, W. J., Togias, A., Zuberbier, T., Baena‐Cagnani, C. E., Canonica, G. W., Van Weel, C., et al. (2008) · Allergy · doi:10.1111/j.1398-9995.2007.01620.x · Cited by 4,729
Expert Panel Report 2: Guidelines for the Diagnosis and Management of Asthma
Program, P., & theDiagnosis, T. E. P. O. (1997) · Cited by 4,082
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British Thoracic Society Scottish Intercollegiate Guidelines Network (2008) · Thorax · doi:10.1136/thx.2008.097741 · Cited by 2,023
Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 Revision
Brożek, J. L., Bousquet, J., Baena-Cagnani, C. E., Bonini, S., Canonica, G. W., Casale, T. B., van Wijk, R. G., Ohta, K., Zuberbier, T., & Schünemann, H. J. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.06.047 · Cited by 1,813
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Cox, L., Nelson, H., Lockey, R., Calabria, C., Chacko, T., Finegold, I., Nelson, M., Weber, R., Bernstein, D. I., Blessing-Moore, J., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.09.034 · Cited by 1,256
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WALLACE, D., DYKEWICZ, M., BERNSTEIN, D., BLESSINGMOORE, J., COX, L., KHAN, D., LANG, D., NICKLAS, R., OPPENHEIMER, J., & PORTNOY, J. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.06.003 · Cited by 1,096
The Journal of Allergy and Clinical Immunology
(1999) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(99)70212-5 · Cited by 1,093
Treatment strategies for allergy and asthma
Holgate, S. T., & Polosa, R. (2008) · Nature reviews. Immunology · doi:10.1038/nri2262 · Cited by 713
International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
Wise, S. K., Lin, S. Y., Toskala, E., Orlandi, R. R., Akdis, C. A., Alt, J. A., Azar, A., Baroody, F. M., Bachert, C., Canonica, G. W., et al. (2018) · International Forum of Allergy & Rhinology · doi:10.1002/alr.22073 · Cited by 557
International consensus on allergy immunotherapy
Jutel, M., Agache, I. O., Bonini, S., Burks, A. W., Calderón, M. A., Canonica, G. W., Cox, L., Demoly, P. M., Frew, A. J., O’Hehir, R. E., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.04.047 · Cited by 544
International consensus statement on allergy and rhinology: Allergic rhinitis – 2023
Wise, S. K., Damask, C. C., Roland, L. T., Ebert, C. S., Levy, J. M., Lin, S. Y., Luong, A., Rodriguez, K., Sedaghat, A. R., Toskala, E. M., et al. (2023) · International Forum of Allergy & Rhinology · doi:10.1002/alr.23090 · Cited by 584
Cox, L., Larenas‐Linnemann, D. E., Lockey, R. F., & Passalacqua, G. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.10.060 · Cited by 506
Canonica, G. W., Baena‐Cagnani, C. E., Bousquet, J., Bousquet, P., Lockey, R. F., Malling, H. ‐., Passalacqua, G., Potter, P., & Valovirta, E. J. (2007) · Allergy · doi:10.1111/j.1398-9995.2006.01312.x · Cited by 439
Standards for practical allergen‐specific immunotherapy
Alvarez‐Cuesta, E., Bousquet, J., Canonica, G. W., Durham, S. R., Malling, H., & Valovirta, E. J. (2006) · Allergy · doi:10.1111/j.1398-9995.2006.01219_1.x · Cited by 402
Frew, A. J., Powell, R. J., Corrigan, C. J., & Durham, S. R. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.11.014 · Cited by 372
Guideline on allergen-specific immunotherapy in IgE-mediated allergic diseases
Pfaar, O., Bachert, C., Bufe, A., Buhl, R., Ebner, C., Eng, P. A., Friedrichs, F., Fuchs, T., Hamelmann, E. H., Hartwig-Bade, D., et al. (2014) · Allergo Journal International · doi:10.1007/s40629-014-0032-2 · Cited by 349
Rienzo, V. D., Marcucci, F., Puccinelli, P., Parmiani, S., Frati, F., SENSI, L. G., Canonica, G. W., & Passalacqua, G. (2003) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2003.01587.x · Cited by 347
Self-citationAllergic Rhinitis and its Impact on Asthma update: Allergen immunotherapy
Passalacqua, G., & Durham, S. R. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.01.045 · Cited by 276
Canonica, G. W., Bousquet, J., Casale, T. B., Lockey, R. F., Baena‐Cagnani, C. E., Pawankar, R., Potter, P. C., Bousquet, P., Cox, L., Durham, S. R., et al. (2009) · World Allergy Organization Journal · doi:10.1097/wox.0b013e3181c6c379 · Cited by 252
EAACI guidelines on allergen immunotherapy: Prevention of allergy
Halken, S., Larenas‐Linnemann, D. E., Roberts, G. C., Calderón, M. A., Angier, E., Pfaar, O., Ryan, D. P., Agache, I. O., Ansotegui, I. J., Arasi, S., et al. (2017) · Pediatric Allergy and Immunology · doi:10.1111/pai.12807 · Cited by 243
Allergen immunotherapy: A practice parameter second update
Cox, L., Li, J. T., Nelson, H. S., & Lockey, R. F. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.06.019 · Cited by 239
Preventive effects of sublingual immunotherapy in childhood: an open randomized controlled study
Marogna, M., Tomassetti, D., Bernasconi, A., Colombo, F., Massolo, A., Rienzo Businco, A. D., Canonica, G. W., Passalacqua, G., & Tripodi, S. (2008) · Annals of Allergy, Asthma & Immunology · doi:10.1016/s1081-1206(10)60211-6 · Cited by 234
GA2LEN/EAACI pocket guide for allergen‐specific immunotherapy for allergic rhinitis and asthma
Zuberbier, T., Bachert, C., Bousquet, P. J., Passalacqua, G., Walter Canonica, G., Merk, H., Worm, M., Wahn, U., & Bousquet, J. (2010) · Allergy · doi:10.1111/j.1398-9995.2010.02474.x · Cited by 227
Allergen immunotherapy for the prevention of allergy: A systematic review and meta‐analysis
Kristiansen, M., Dhami, S., Netuveli, G., Halken, S., Muraro, A. M., Roberts, G. C., Larenas‐Linnemann, D. E., Calderón, M. A., Penagos, M., Toit, G. D., et al. (2016) · Pediatric Allergy and Immunology · doi:10.1111/pai.12661 · Cited by 208
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Marogna, M., Spadolini, I., Massolo, A., Canonica, G. W., & Passalacqua, G. (2004) · Allergy · doi:10.1111/j.1398-9995.2004.00508.x · Cited by 180
Ott, H., Sieber, J., Brehler, R., Fölster‐Holst, R., Kapp, A., Klimek, L., Pfaar, O., & Merk, H. F. (2008) · Allergy · doi:10.1111/j.1398-9995.2008.01875.x · Cited by 149
Marple, B. F., Fornadley, J. A., Patel, A. A., Fìneman, S. M., Fromer, L. M., Krouse, J. H., Lanier, B. Q., & Penna, P. (2007) · Otolaryngology · doi:10.1016/j.otohns.2007.02.031 · Cited by 147
Möbs, C., Slotosch, C., Löffler, H., Jakob, T., Hertl, M., & Pfützner, W. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901379 · Cited by 137
İnal, A. S., Altıntaş, D. U., Yilmaz, M., Karakoç, G. B., Kendirli, S. G., & Sertdemır, Y. (2007) · PubMed · Cited by 134
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Sakashita, M., Hirota, T., Harada, M., Nakamichi, R., Tsunoda, T., Osawa, Y., Kojima, A., Okamoto, M., Suzuki, D., Kubo, S., et al. (2009) · International Archives of Allergy and Immunology · doi:10.1159/000242363 · Cited by 128
Hankin, C. S., Cox, L., Lang, D. M., Levin, A., Gross, G., Eavy, G., Meltzer, E. O., Burgoyne, D., Bronstone, A. B., & Wang, Z. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.10.026 · Cited by 112
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Pajno, G. B., Vita, D., Parmiani, S., Caminiti, L., Grutta, S. L., & Barberio, G. (2003) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2003.01809.x · Cited by 101
Self-citationOtt, H., Sieber, J., Brehler, R., Fölster‐Holst, R., Kapp, A., Klimek, L., Pfaar, O., & Merk, H. F. (2009) · Allergy · doi:10.1111/j.1398-9995.2009.02194.x · Cited by 100
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Berger, W. E. (2004) · Pediatric Drugs · doi:10.2165/00148581-200406040-00003 · Cited by 96
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Passalacqua, G., Guerra, L., Pasquali, M., Lombardi, C., & Canonica, G. W. (2004) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)61440-8 · Cited by 92
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IV Brazilian Consensus on Rhinitis – an update on allergic rhinitis
Sakano, E., Sarinho, E. S. C., Cruz, Á. A., Pastorino, A. C., Tamashiro, E., Kuschnir, F. C., Castro, F. F. M., Romano, F. R., Wandalsen, G. F., Chong‐Neto, H. J., et al. (2017) · Brazilian Journal of Otorhinolaryngology · doi:10.1016/j.bjorl.2017.10.006 · Cited by 92
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Wang, C., Bao, Y., Chen, J., Chen, X., Cheng, L., Guo, Y. S., Hao, C., Lai, H., Li, H., Li, J., et al. (2022) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2022.14.6.604 · Cited by 83
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Cox, L. (2006) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)60003-8 · Cited by 81
Allergen-specific immunotherapy in allergic rhinitis and asthma. Mechanisms and proof of efficacy
Pipet, A., Botturi, K., Pinot, D., VERVLOET, D., & Magnan, A. (2009) · Respiratory Medicine · doi:10.1016/j.rmed.2009.01.008 · Cited by 75
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Larché, M. (2007) · Allergy · doi:10.1111/j.1398-9995.2006.01309.x · Cited by 76
Allergy Immunotherapy Adherence and Delivery Route: Location Does Not Matter
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Bona, D. D., Plaia, A., Leto‐Barone, M. S., Piana, S. L., Macchia, L., & Lorenzo, G. D. (2016) · Allergy · doi:10.1111/all.13104 · Cited by 72
Jacobsen, L., Wahn, U., & Bilò, M. B. (2012) · Clinical and Translational Allergy · doi:10.1186/2045-7022-2-8 · Cited by 71
van Rijt, L. S., Vos, N., Willart, M. A. M., Muskens, F., Tak, P. P., van der Horst, C., Hoogsteden, H. C., & Lambrecht, B. N. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201101-0019oc · Cited by 72
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Baena‐Cagnani, C. E. (2004) · Drug Safety · doi:10.2165/00002018-200427120-00005 · Cited by 64
Szépfalusi, Z., Bannert, C., Ronceray, L., Mayer, E., Hassler, M., Wissmann, E., Dehlink, E., Gruber, S., Graf, A. C., Lupinek, C., et al. (2014) · Pediatric Allergy and Immunology · doi:10.1111/pai.12310 · Cited by 63
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Kleine‐Tebbe, J., Bergmann, K., Friedrichs, F., Fuchs, T., Jung, K., Klimek, L., Kühr, J., Lässig, W., Lepp, U. S., Niggemann, B., et al. (2006) · Allergologie · doi:10.5414/alp29135 · Cited by 61
Calderón, M. A., Cardona, V., Demoly, P. M., & Panel, O. B. O. T. E. 1. Y. O. I. E. (2012) · Allergy · doi:10.1111/j.1398-9995.2012.02785.x · Cited by 60
Campo, P., Salas, M., Blanca-López, N., & Rondón, C. (2016) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2015.12.008 · Cited by 59
Eisenbarth, S. C., Zhadkevich, A., Ranney, P., Herrick, C. A., & Bottomly, K. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.7.4527 · Cited by 59
Allergen Immunotherapy in Allergic Respiratory Diseases
Viswanathan, R. K., & Busse, W. W. (2012) · CHEST Journal · doi:10.1378/chest.11-2800 · Cited by 56
Chinese Guideline on allergen immunotherapy for allergic rhinitis
Bao, Y., Chen, J., Cheng, L., Guo, Y., Hong, S., Kong, W., Lai, H., Li, H., Li, H., Li, J., et al. (2017) · Journal of Thoracic Disease · doi:10.21037/jtd.2017.10.112 · Cited by 56
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Bachert, C., & Cauwenberge, P. V. (2003) · KARGER eBooks · doi:10.1159/000071546 · Cited by 56
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Nieto, A., Wahn, U., Bufe, A., Eigenmann, P., Halken, S., Hedlin, G., Høst, A., Hourihane, J. O., Just, J., Lack, G., et al. (2014) · Pediatric Allergy and Immunology · doi:10.1111/pai.12272 · Cited by 57
Health-Economic Analyses of subcutaneous Specific Immunotherapy for grass pollen and mite allergy
Petersen, K. D., Gyrd‐Hansen, D., & Dahl, R. (2005) · Allergologia et Immunopathologia · doi:10.1016/s0301-0546(05)73246-8 · Cited by 54
Economic evaluation of sublingual vs subcutaneous allergen immunotherapy
Pokladníková, J., Krčmová, I., & Vlček, J. (2008) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)60475-9 · Cited by 52
Hankin, C. S., & Cox, L. (2014) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000084 · Cited by 51
Cox, L., Calderón, M. A., & Pfaar, O. (2012) · Immunotherapy · doi:10.2217/imt.12.36 · Cited by 51
Treatment of Allergic Rhinitis as a Strategy for Preventing Asthma
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Specific immunotherapy is effective in the prevention of new sensitivities
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Metadata
- Authors
- Purello‐D'Ambrosio, F., Gangemi, S., Merendino, R. A., Isola, S., Puccinelli, P., Parmiani, S., & Ricciardi, L.
- Affiliations
- University of Messina (IT)
- ALK-Abelló (Italy) (IT)
- Corresponding author
- Gangemi, S.
- Venue
- Clinical & Experimental Allergy
- Publisher
- Wiley
- Published
- 2001-08
- Volume
- 31
- Issue
- 8
- Pages
- 1295-1302
- ISSN
- 0954-7894 (ISSN-L)
- 1365-2222
- OpenAlex
- W2085196853
- Cited by
- 281
- References
- 76
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 4 · 2020: 5 · 2019: 6 · 2018: 12 · 2017: 13 · 2016: 16 · 2015: 14 · 2014: 17 · 2013: 9 · 2012: 14
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical & Experimental Allergy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Keywords
- allergen immunotherapy, polysensitization, allergic respiratory diseases, asthma, allergic rhinitis, antiallergic drugs, specific IgE, total IgE, allergen sensitization
- MeSH terms
- Contraindications, Administration, Inhalation, Administration, Oral, Adult, Allergens, Epitopes, Asthma, Desensitization, Immunologic, Drug Administration Schedule, Female, Follow-Up Studies, Histamine H1 Antagonists, Humans, Hypersensitivity, Delayed, Immunoglobulin E, Italy, Male, Retrospective Studies, Rhinitis, Receptors, Adrenergic, beta-2, Anti-Allergic Agents, Adrenergic beta-2 Receptor Agonists
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