The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Significance of chemokines and activated platelets in patients with diabetes
Open accessAbstract
SUMMARY: Levels of platelet-derived microparticles (PMPs), platelet activation markers (P-selectin expressed on, or annexin V binding to, platelets (plt:P-selectin or plt:annexin V, respectively)), chemokines (IL-8, monocyte chemotactic peptide-1 (MCP-1), and regulated on activation normally T-cell expressed and secreted (RANTES)), and soluble P- and E-selectins were compared in peripheral blood from diabetic and control patients in order to develop a better understanding of their potential contribution to diabetic vascular complications. Significant increases were found for PMPs, plt:P-selectin, MCP-1, RANTES and soluble P- and E-selectins in diabetic individuals, whereas IL-8 levels were similar. Furthermore, after ticlopidine treatment, most of these factors receded to baseline levels observed in non-diabetic patients. Our findings indicate that ticlopidine might be able to prevent or reduce vascular complications in diabetic patients.
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Cites
Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477
Large Platelets Circulate in an Activated State in Diabetes Mellitus
Tschoepe, D., Roesen, P., Esser, J., Schwippert, B., Nieuwenhuis, H., Kehrel, B., & Gries, F. (1991) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2007-1002650 · Cited by 266
Cited by
Diabetes and Vascular Disease: Pathophysiology, Clinical Consequences, and Medical Therapy: Part I
Creager, M. A., Lüscher, T. F., of, P. W. T. A., Cosentino, F., & Beckman, J. A. (2003) · Circulation · doi:10.1161/01.cir.0000091257.27563.32 · Cited by 1,650
Monocyte chemoattractant protein 1 in obesity and insulin resistance
Sartipy, P., & Loskutoff, D. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1133870100 · Cited by 1,201
The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance
Goossens, G. H. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.10.010 · Cited by 591
Bruun, J. M., Lihn, A. S., Pedersen, S. B., & Richelsen, B. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1696 · Cited by 535
Cellular microparticles: a disseminated storage pool of bioactive vascular effectors
Morel, O., Toti, F., Hugel, B., & Freyssinet, J.-M. (2004) · Current Opinion in Hematology · doi:10.1097/01.moh.0000131441.10020.87 · Cited by 454
Metadata
- Authors
- Nomura, S., Shouzu, A., Omoto, S., Nishikawa, M., & Fukuhara, S.
- Venue
- Clinical and Experimental Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-09
- Volume
- 121
- Issue
- 3
- Pages
- 437-443
- ISSN
- 0009-9104 (ISSN-L)
- 1365-2249
- OpenAlex
- W2015372874
- Cited by
- 180
- References
- 2
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- green
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- Nomura, S., Shouzu, A., Omoto, S., Nishikawa, M., & Fukuhara, S. (2001). Significance of chemokines and activated platelets in patients with diabetes. Clinical and Experimental Immunology. https://doi.org/10.1046/j.1365-2249.2000.01324.x
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