Cited by 301Ovarian function and disordersReproductive Biology and FertilityAdrenal Hormones and Disorders

The DOI matches its Crossref record.

Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome

Gilling‐Smith, C., Story, H, Rogers, V., Franks, S.·1997·Clinical Endocrinology

DOI 10.1046/j.1365-2265.1997.2321049.x

Open this paper in CoChat — free account

Abstract

OBJECTIVE: Polycystic ovary syndrome (PCOS) is a common endocrinopathy of unknown aetiology. The aims of this study were to identify whether ovarian thecal cell steroidogenesis is abnormally regulated in PCOS by measuring steroid responses to a single dose of hCG before, and during, suppression of endogenous LH levels by GnRH analogue (GnRHa). DESIGN: Serum levels of LH, FSH, 17 alpha hydroxyprogesterone (17OHP), androstenedione, testosterone and dehydroepiandrosterone sulphate were measured before, and 48 hours after, a single intramuscular injection of 10,000 IU hCG. The test was repeated 4 weeks after suppression of endogenous LH levels by GnRHa. PATIENTS: The ovarian responses to hCG were compared in three groups of women. Eleven women had normal ovaries and regular cycles, eight had polycystic ovaries but not clinical features of the syndrome (PCO group) and eight had polycystic ovaries, anovulation and either severe hirsutism or alopecia (PCOS group). RESULTS: Before GnRHa treatment, LH levels were significantly higher in the PCOS group but hCG stimulated a similar rise in 17OHP in all three groups. Following analogue, LH levels were suppressed in all three groups but the 17OHP responses to hCG were significantly higher in both the PCO and PCOS groups compared with normal controls. CONCLUSIONS: These findings provide further evidence in favour of an intrinsic abnormality of thecal cell steroidogenesis in the polycystic ovary.

Integrity signals

Registry

Crossref · 10.1046/j.1365-2265.1997.2321049.x

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 201–300 of 300

Effectiveness of Laser Acupoints on Women With Polycystic Ovarian Syndrome: A Randomized Controlled Trial
El-Shamy, F., El-kholy, S. S., & Mohamed, M. A. E.-R. (2018) · Journal of lasers in medical sciences · doi:10.15171/jlms.2018.22 · Cited by 11
The 6th Annual World Congress on the Insulin Resistance Syndrome
Bloomgarden, Z. T. (2009) · Diabetes Care · doi:10.2337/dc09-zb09 · Cited by 11
PCOS and Inositols – Advances and Lessons We are Learning. A Narrative Review
Lentini, G., Querqui, A., Monti, N., & Bizzarri, M. (2025) · Drug Design Development and Therapy · doi:10.2147/dddt.s524718 · Cited by 16
Women with polycystic ovary syndrome and other causes of infertility have a higher prevalence of GSTT1 deletion
Alves, M. M. C., Almeida, M., Oliani, A. H., Breitenfeld, L., & Ramalhinho, A. C. (2020) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2020.06.010 · Cited by 10
Effect of the spatial–temporal specific theca cell Cyp17 overexpression on the reproductive phenotype of the novel TC17 mouse
Secchi, C., Belli, M., Harrison, T. N. H., Swift, J., Ko, C. J., Dulęba, A. J., Stupack, D. G., Chang, R. J., & Shimasaki, S. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03103-x · Cited by 11
The Androgen-Conjugating Uridine Diphosphoglucuronosyltransferase-2B Enzymes Are Differentially Expressed Temporally and Spatially in the Monkey Follicle throughout the Menstrual Cycle
Barbier, O., Girard, C., Berger, L., Alfy, M. E., Bélanger, A., & Hum, D. W. (2001) · Endocrinology · doi:10.1210/endo.142.6.8040 · Cited by 10
LH suppression following different low doses of the GnRH antagonist ganirelix in polycystic ovary syndrome
Hohmann, F. P., Laven, J. S. E., Mulders, A. G. M. G. J., Oberyé, J., Mannaerts, B. M. J. L., de Jong, F. H., & Fauser, B. C. J. M. (2005) · Journal of Endocrinological Investigation · doi:10.1007/bf03345337 · Cited by 10
Effects of metformin on inappropriate LH release in women with polycystic ovarian syndrome and insulin resistance
Ulloa‐Aguirre, A., Portocarrero-Ortiz, L. A., Zariñán, T., Olivares, A., Carranza‐Lira, S., Veldhuis, J. D., & López-Alvarenga, J. C. (2006) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)61079-6 · Cited by 10
Remedy hope for polycystic ovary syndrome
Stener‐Victorin, E. (2024) · Science · doi:10.1126/science.adq0328 · Cited by 9
Insulinorésistance et syndrome des ovaires polykystiques
Bernard, L., Christin‐Maître, S., Basille, C., & Chabbert‐Buffet, N. (2003) · Gynécologie Obstétrique & Fertilité · doi:10.1016/s1297-9589(03)00009-2 · Cited by 9
Polycystic ovary syndrome
(2008) · Reproductive medicine and assisted reproductive techniques series · doi:10.3109/9781439807224.008 · Cited by 9
Hyperandrogenism in the Adolescent Female
Toscano, V., Balducci, R., Mangiantini, A., Falasca, P., & Sciarra, F. (1998) · Steroids · doi:10.1016/s0039-128x(98)00032-4 · Cited by 9
An endocrinological perspective on polycystic ovarian syndrome
Basak, S., Dixit, A. K., Dey, R. K., Puia, L., Bora, M., Yr, S. K., & Babu, G. (2025) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2025.112524 · Cited by 11
Androgen production and action in the ovary
Franks, S. (2021) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2021.02.002 · Cited by 10
Self-citation
Low 11-deoxycortisol to cortisol conversion reflects extra-adrenal factors in the majority of women with normo-gonadotrophic normo-estrogenic infertility
Dolfing, J. G. (2003) · Human Reproduction · doi:10.1093/humrep/deg082 · Cited by 7
“The presence of defects in ovarian and adrenal steroidogenesis of women with infertility has been previously reported in the laboratory (Gilling-Smith et al., 1997) and in clinical studies (Gonzalez, 1997; Rosen®eld, 1999).”
Background
The Role of the Ovary in the Genesis of Hyperandrogenism
Magoffin, D. A. (2004) · Elsevier eBooks · doi:10.1016/b978-012444562-8/50031-8 · Cited by 8
Effects of vitex agnes castus on hormonal imbalances in Polycystic Ovary Syndrome
Saul, S. (2017) · International Journal of Basic & Clinical Pharmacology · doi:10.18203/2319-2003.ijbcp20173295 · Cited by 7
Individual 17-Hydroxyprogesterone Responses to hCG Are Not Correlated With Follicle Size in Polycystic Ovary Syndrome
Homer, M. V., Toloubeydokhti, T., Lawson, M. A., Garzo, G., Dulęba, A. J., & Chang, R. J. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2018-00339 · Cited by 7
“In a subsequent clinical study, the same authors examined 17-OHP and A4 responses to hCG stimulation in women with PCOS and normal women before and 1month after an injection of a long-actingGnRHagonist [22].”
Background
Altered multihormone synchrony in obese patients with polycystic ovary syndrome
Roelfsema, F., Kok, P., Veldhuis, J. D., & Pijl, H. (2011) · Metabolism · doi:10.1016/j.metabol.2010.12.011 · Cited by 7
Polyendocrine metabolic ovarian syndrome in pregnancy: pathophysiology and outcomes
Teede, H. J., Vanky, E., Piltonen, T., Stener‐Victorin, E., Moran, L., & Khomami, M. B. (2026) · Nature Reviews Endocrinology · doi:10.1038/s41574-026-01261-w · Cited by 11
The effect of rapamycin treatment on mouse ovarian follicle development in dehydroepiandrosterone-induced polycystic ovary syndrome mouse model
Yıldırım, E., Önel, T., Ağuş, S., Günalan, E., Yılmaz, B., Aydın, M. Ş., & Yaba, A. (2024) · Zygote · doi:10.1017/s0967199424000388 · Cited by 7
Steroidogenic abnormalities in ovarian theca cells in polycystic ovary syndrome
Wickenheisser, J. K., Strauss, J. F., & McAllister, J. M. (2002) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-200212000-00008 · Cited by 6
Association Between Single Nucleotide Polymorphisms (rs1484215 and rs6495096) in CYP11A1 Gene in Iranian Women with Polycystic Ovary Syndrome
Fathy, P., Cheraghi, E., & Miresmaeili, S. M. (2023) · Journal of Reproduction & Infertility · doi:10.18502/jri.v24i1.11905 · Cited by 6
“Thecal cells cultured from PCOS samples indicate enhanced androgen production or enhanced CYP11A mRNA expression compared to samples from control women (31).”
Background
17-Hydroxyprogesterone responses to human chorionic gonadotropin are not associated with serum anti-Mullerian hormone levels among adolescent girls with polycystic ovary syndrome
Hou, J., Cook‐Andersen, H., Su, H.-C. I., Shayya, R. F., Maas, K. H., Solorzano, C. M. B., Kumar, A., & Chang, R. J. (2016) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2015-0461 · Cited by 6
“Because women with PCOS exhibit increased 17-hydroxyprogesterone (17-OHP) responses to gonadotropin stimulation compared to that of normal women, it has been suggested that cytochrome P450 (CYP17) is dysregulated and probably reflects an inherent defect of theca cell androgen production [3, 4].”
Insulin Resistance and Lipotoxicity in PCOS: Causes and Consequences
Bellanger, S., Battista, M., & Baillargeon, J. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8394-6_7 · Cited by 5
Defects in Ovarian Steroid Hormone Biosynthesis
Strauss, J. F., Modi, B. P., & McAllister, J. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-408134-5.00018-4 · Cited by 10
Differential activity of the corticosteroidogenic enzymes in normal cycling women and women with polycystic ovary syndrome
Yamamoto, M. M. W., & de Medeiros, S. F. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09482-3 · Cited by 7
Das polyzystische Ovarsyndrom
Heutling, D., Schulz, H., Randeva, H. S., Dodt, C., & Lehnert, H. (2007) · Der Internist · doi:10.1007/s00108-006-1776-7 · Cited by 7
Hyperandrogenism, Hirsutism, and Polycystic Ovary Syndrome
Barnes, R. B., Ehrmann, D. A., & Rosenfield, R. L. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00132-5 · Cited by 6
The Role of Gene Alterations in the Pathogenesis of Polycystic Ovary Syndrome
Carmina, E. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14103347 · Cited by 5
Endocrine and metabolic changes in women with polycystic ovaries and polycystic ovary syndrome
Koivunen, R. M. (2001) · Cited by 5
Polycystic Ovary Syndrome and Hyperandrogenic States
Chang, R. J. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4557-2758-2.00022-6 · Cited by 4
Comparison between buserelin and dexamethasone testing in the assessment of hirsutism
Re, T., Barbetta, L., Dall’Asta, C., Faglia, G., & Ambrosi, B. (2002) · Journal of Endocrinological Investigation · doi:10.1007/bf03343965 · Cited by 4
Fetal programming of polycystic ovary syndrome
Abbott, D. H., Bruns, C. M., Barnett, D. K., & Dumesic, D. A. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511545191.016 · Cited by 5
Phytotherapy in Polycystic Ovary Syndrome (PCOS) Management: A Systematic Review
Mohamed, S. S., Allam, A. T., Elalfy, A., El‐Shiekh, R. A., Reda, A. M., & Hafeez, M. S. A. E. (2025) · Chemistry & Biodiversity · doi:10.1002/cbdv.202500982 · Cited by 6
“Upregulated steroidogenesis in PCOS theca cells suggests that the genetic defect in PCOS may involve signal transduction pathways regulating the expression of a specific family of genes [60].”
Changes in antral follicle dynamics following weight loss in women with polycystic ovary syndrome
Carter, F. E., Jarrett, B. Y., Lee, N. D., Zaman, N., Reich, A., Wilson, K. A., Oldfield, A. L., Brink, H. V., & Lujan, M. E. (2025) · Human Reproduction · doi:10.1093/humrep/deaf169 · Cited by 4
Clomiphene Citrate versus Letrozole for Ovulation Induction in PCOS: A Comparative Study
Nambiar, S. S. (2018) · Journal of South Asian Federation of Obstetrics and Gynaecology · doi:10.5005/jp-journals-10006-1631 · Cited by 5
Le syndrome des ovaires polykystiques : quelles nouveautés en 2019 ?
Gourbesville, C., Kerlan, V., & Reznik, Y. (2019) · Annales d Endocrinologie · doi:10.1016/s0003-4266(19)30114-3 · Cited by 5
Polycystic Ovary Syndrome and Hyperandrogenic States
Chang, R. J. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4907-4.00020-6 · Cited by 5
The Genetics of Polycystic Ovary Syndrome: From Genome-Wide Association to Molecular Mechanisms
Strauss, J. F., Modi, B. P., & McAllister, J. M. (2018) · Reproductive medicine for clinicians · doi:10.1007/978-3-319-78009-2_3 · Cited by 3
Hydroxychloroquine enhances insulin sensitivity and ameliorates abnormal lipid metabolism in obese women with polycystic ovary syndrome
Wang, R., Qi, S., Wang, Q., Lang, J., Pang, C., & Wang, K. (2025) · BMC Endocrine Disorders · doi:10.1186/s12902-024-01827-7 · Cited by 3
Chronic Fructose Consumption May be used as a Model of Polycystic Ovary Syndrome in Pregnant Female Sprague-Dawley Rats
Arikawe, A., Iranloye, B. O., Ogunsola, A., & Daramola, A. O. (2012) · African Journal of Biomedical Research · Cited by 3
Hiperandrogenismo en la mujer diabética: rol de la resistencia insulínica y de la hiperinsulinemia
Tejada, G. G.-R. D., & Escobar-Morreale, H. F. (2003) · Endocrinología y Nutrición · doi:10.1016/s1575-0922(03)74555-0 · Cited by 3
The Role of Leptin in Polycystic Ovary Syndrome
Magoffin, D. A., Duggal, P. S., & Norman, R. J. (2003) · Springer eBooks · doi:10.1007/978-1-4615-0157-2_20 · Cited by 3
Endocrine Indices of PCOS in Women with Polycystic Ovaries but without Diagnostic Features of PCOS: A Study of an Infertility Clinic Population
Κousta, E., White, D. M., Johnston, D. G., & Franks, S. (2020) · Open Journal of Obstetrics and Gynecology · doi:10.4236/ojog.2020.1020024 · Cited by 2
“These findings mirror those in a study by Gilling-Smith and colleagues [16] in which hyperandrogenism in women with PCO and regular cycles was only revealed after stimulation by a dose of hCG.”
ResultSelf-citation
Ovarian Dysfunction in Polycystic Ovary Syndrome (PCOS)
Mason, H. D., Dilaver, N., & Rice, S. (2022) · Springer eBooks · doi:10.1007/978-3-030-92589-5_6 · Cited by 3
Complementary administration of curcumin in PCOS: a systematic review
Venkatesan, K., Menon, S., Firoz, I. N., Narendrula, R., Kunnath, J. T., KALAPURAKAL, A. M., Ashok, A., IQBAL, A. M., & Haroon, N. N. (2022) · Minerva Obstetrics and Gynecology · doi:10.23736/s2724-606x.22.05129-6 · Cited by 2
Menstrual Disorders and Hyperandrogenism in Adolescence
DiVall, S. A., & Rosenfield, R. L. (2013) · Humana Press eBooks · doi:10.1007/978-1-60761-395-4_25 · Cited by 2
Ovarian Morphology Is a Marker of Heritable Biochemical Traits in Sisters With Polycystic Ovaries
Franks, S., Webber, L. J., Goh, M. J., Valentine, A., White, D. M., Conway, G. S., Wiltshire, S., & McCarthy, M. I. (2009) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000344392.60303.43 · Cited by 2
“Serum LH and FSH were measured by the sandwich immunoassay by immuno 1analyzer(BayerCorp.,Tarrytown,NY).Interassaycoefficientsofvariation for FSH and LH were less than 2.5% ( 19 ).”
MethodInfluentialSelf-citation
Pathogenesis of Hyperandrogenism in Polycystic Ovary Syndrome
Chang, W. Y., & Azziz, R. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-108-6_17 · Cited by 2
“Women with PCOS and isolated polycystic ovaries demonstrate a higher 17-OHP production in response to hCG challenge than do control women ( 19 ).”
Background
EFFECT OF INCREASED TESTOSTERONE LEVEL ON WOMAN'S FERTILITY
Papiæ, Z. (2004) · Cited by 2
Validation of the obese Ossabaw miniature pig as a model of the obese polycystic ovary syndrome phenotype with concomitant metabolic syndrome: Exploration of polycystic ovary syndrome pathophysiology using in vivo and in vitro models
Newell-Fugate, A. E. (2012) · Cited by 2
Ovarian Function in Assisted Reproduction
Gilling‐Smith, C., & Franks, S. (2004) · Elsevier eBooks · doi:10.1016/b978-012444562-8/50029-x · Cited by 2
Self-citation
Das polyzystische Ovarsyndrom: Prototyp eines kardiometabolischen Syndroms
Heutling, D., Schulz, H., Randeva, H. S., Dodt, C., & Lehnert, H. (2007) · Der Internist · Cited by 2
Polycystic ovary syndrome: What is it? Pathogenetic enigma and therapeutic dilemma
Toscano, V. (1998) · Journal of Endocrinological Investigation · doi:10.1007/bf03350779 · Cited by 2
Insulin resistance in polycystic ovary syndrome
Morin-Papunen, L. C. (2000) · Cited by 2
Ovarian Dysfunction in Polycystic Ovary Syndrome
Mason, H. D., Dilaver, N., & Rice, S. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8394-6_4 · Cited by 1
Ovaire normal, variations physiologiques et pathologies fonctionnelles de l'ovaire
Bazot, M., Nassar, J., Jonard, S. C., et al. (2004) · EMC - Radiologie · doi:10.1016/j.emcrad.2004.08.002 · Cited by 1
Gynecologic disorders which can cause infertility
Lyttleton, J. (2013) · Elsevier eBooks · doi:10.1016/b978-0-7020-3176-2.00005-0 · Cited by 1
Kontrowersje wokół patogenezy zespołu policystycznych jajników
Szydlarska, D., Grzesiuk, W., & Bar‐Andziak, E. (2010) · Via Medica Journals · Cited by 2
Polycystic Ovary Syndrome: Pathophysiology, Presentation and Treatment a Mini-Review Article
Simic, D., Stefanovic, K., Djurić, D., & Turnić, T. N. (2021) · Serbian Journal of Experimental and Clinical Research · doi:10.2478/sjecr-2020-0053 · Cited by 2
Insulin Resistance and Lipotoxicity in PCOS: Causes and Consequences
Carreau, A., Battista, M., & Baillargeon, J. (2022) · Springer eBooks · doi:10.1007/978-3-030-92589-5_8 · Cited by 1
Insulino-resistenza e fertilità nella donna con attenzione a sindrome dell’ovaio policistico (PCOS) e malattia epatica non alcoolica (NAFLD)
Stasi, V. D., Cipriani, S., Maseroli, E., Scavello, I., & Vignozzi, L. (2022) · L Endocrinologo · doi:10.1007/s40619-022-01037-0 · Cited by 1
“Anche la disfunzione intrinseca delle cellule della teca contribuisce all’iperandrogenismo ovarico nelle donne con PCOS [10].”
Correlation of severity of hyperandrogenism with ovarian stroma to area ratio and stromal echogenicity in polycystic ovary syndrome patients
Gupta, P., & Gaikwad, H. S. (2015) · International Journal of Reproduction Contraception Obstetrics and Gynecology · doi:10.18203/2320-1770.ijrcog20151610 · Cited by 1
Conceptos básicos sobre infertilidad, incluido el síndrome de poliquistosis ovárica
Brassard, M., Ainmelk, Y., & Baillargeon, J. (2008) · Clínicas médicas de Norteamérica · doi:10.1016/s0186-0194(08)92058-x · Cited by 1
Metformin for the Treatment of Polycystic Ovary Syndrome (PCOS)
Patel, S. S., Beshay, V. E., & Carr, B. R. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-392-3_2
“In patients with insulin resistance, improving insulin sensitivity via pharmacologic agents would logically appear to increase ovulation rates (31, 49, 50 ) . Unlike treatment with CC or gonadotropins, metformin therapy does not appear to accelerate follicular recruitment.”
Background
Efectos del resveratrol en la fisiología ovárica y su potencial aplicación en el síndrome de ovario poliquístico
Sánchez, I. O. (2014) · BURJC Digital (King Juan Carlos University)
Aspects of Mono- and Multiple Dominant Follicle Development in the Human Ovary
Hohmann, F. P. (2005) · RePub (Erasmus University Rotterdam)
La sindrome dell’ovaio policistico
Toscano, V. (2000) · L Endocrinologo · doi:10.1007/bf03344362
Prevalencia de ovario poliquístico en adolescentes sanas y en adolescentes con antecedentes de pubarquía precoz. Nuevas aportaciones de la ecografía tridimensional
Cuevas, N. C. (2012) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
The feasibility of long-term treatment of polycystic ovary syndrome with GnRH-agonists
Berga, S. L. (1998) · Journal of Endocrinological Investigation · doi:10.1007/bf03350789
Syndrome des ovaires polykystiques en période péripubertaire : polymorphisme clinique, biologique, métabolique et génétique
Trimeche, S., Dieudonne, J.-F. T. D., Jeandel, C., Paris, F., Brum, I. S., Orio, F., & Sultan, C. (2004) · EMC - Gynécologie-obstétrique · doi:10.1016/j.emcgo.2004.10.004
Hormonal regulation of microRNA expression in the ovary
Luense, L. J. (2012) · KU ScholarWorks (The University of Kansas)
Effects of the insulin sensitizing drug metformin on ovarian function, follicular growth and ovulation rate in obese women with oligomenorrhoea
Parade, A. (1999)
Effects of elevated testosterone levels on reproductive neuroendocrine function and behavior in female rheus macaques (macaca mulatta)
McGee, W. K. (2015) · doi:10.6083/m4vm4992
Pathophysiology and Clinical Assessment of Hyperandrogenic States
Santagni, S., Rattighieri, E., Chierchia, E., Despini, G., & Genazzani, A. D. (2014) · ISGE series · doi:10.1007/978-3-319-03494-2_8
Age-related androgen secretion in healthy women and in women with polycystic ovary syndrome
Piltonen, T. (2004)
Unravelling the link between insulin resistance and androgen excess
O’Reilly, M. (2015) · University of Birmingham Institutional Research Archive (University of Birmingham)
Pubertal Precursors of the Polycystic Ovarian Syndrome
Marshall, J. C., McCartney, C. R., Blank, S. K., & Okonkwo, Q. L. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-108-6_7
CLINICO-FUNCTIONAL STATE OF THE HYPOTHALAMO-HYPOOHYSIAL ADRENALO-OVARIAN SYSTEM IN THE PATIENTS WITH POLYCYSTIC OVARY SYNDROME
Teryoshin, A. T., Логвина, Л. Л., & Бучко, Л. А. (2013) · CyberLeninK (CyberLeninka)
Current Developments in the Molecular Genetics of the Polycystic Ovary
Gharani, N., Waterworth, D. M., Batty, S., White, D. M., Williamson, R., & McCarthy, M. I. (1998)
RESISTÊNCIA À INSULINA E RISCO CARDIOVASCULAR: ASSOCIAÇÃO COM O POLIMORFISMO NO GENE PAI-1 E PARÂMETROS BIOQUÍMICOS EM MULHERES COM A SÍNDROME DOS OVÁRIOS POLICÍSTICOS
Pós-Graduação, P. D. (2012)
Study on Gender Differences in Acne Vulgaris Associated with Insulin Resistance:A Cross-Sectional StudyPreprint
Mi, W., Feng, X., Wang, Z.-Q., Ye, X., Shu, H., Yu, B., & Li, C. (2021) · Research Square · doi:10.21203/rs.3.rs-519946/v1
“The chronic stimulation of ovary by insulin determines the amount of androgen secretion [24].”
Background
A Study on Physical and Physiological Impact of Polycystic Ovary Syndrome
Sathish Kumar, B. P., Ghosh, S., Das, L., & Jose, A. M. (2021) · International Journal of Pharmaceutical Sciences Review and Research · doi:10.47583/ijpsrr.2021.v69i02.022
“Also the syndrome might be caused by the hypothalamicpituitary axis and impaired insulin activity.(9,10) Moreover, the altered activity in sympathetic nervous system has also been proposed in the etiology.”
Background
Polycystic ovary syndrome - Metformin treatment in pregnancy
Vanky, E. (2005) · NORA - Norwegian Open Research Archives
Redução da resistencia insulinica em mulheres com anovulação cronica hiperandrogenica e sua repercussão nos niveis dos androgenios e da globulina ligadora dos hormonios sexuais
Grassiotto, O. D. R. (1996) · doi:10.47749/t/unicamp.1998.135112
Ovaire normal, variations physiologiques et pathologies fonctionnelles de l'ovaire
Bazot, M., Nassar, J., Jonard, S., et al. (2006) · EMC - Radiologie et imagerie médicale - Génito-urinaire - Gynéco-obstétricale - Mammaire · doi:10.1016/s1879-8543(06)73974-x
Ovarian Diseases
McGee, E. A., & Loucks, T. L. (2007) · Humana Press eBooks · doi:10.1007/978-1-59259-963-9_46
Estimation of BMP-15 gene expression and its Association to Hormonal Profile in Iraq Patient with Polycystic Ovary Syndrome
Khadhum, Z. A., & Al-Deresawi, M. S. (2024) · Wasit Journal of Pure sciences · doi:10.31185/wjps.401
Study the relationship between Fetuin - A and insulin resistance in infertile polycystic ovary syndrome Iraqi women
Kadhim, R. S., & Hassan, F. A. (2024) · AIP conference proceedings · doi:10.1063/5.0236227
10.1016/s0246-1064(19)30232-4
(2000) · Time to knit · doi:10.1016/s0246-1064(19)30232-4
10.1016/s1241-8218(04)40635-0
(2000) · Time to knit · doi:10.1016/s1241-8218(04)40635-0
Connecting polycystic ovary syndrome and pilonidal disease in adolescents: State of the art review
Yung, N. K., Towers, G., Wani, A., Caty, M. G., Cowles, R. A., Solomon, D. G., & Vash‐Margita, A. (2025) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2025.102691
Polycystic ovary syndrome - Effect of acupuncture on insulin resistance and neuroendocrine function
Johansson, J. (2013) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Additional file 2 of Effect of melatonin supplementation on cardiometabolic risk factors, oxidative stress and hormonal profile in PCOS patients: a systematic review and meta-analysis of randomized clinical trials
Ziaei, S., Hasani, M., Malekahmadi, M., Daneshzad, E., Kadkhodazadeh, K., & Heshmati, J. (2024) · Figshare · doi:10.6084/m9.figshare.26182324
Additional file 1 of High-fat and high-sucrose diet impairs female reproduction by altering ovarian transcriptomic and metabolic signatures
Liu, C., Dou, Y., Zhang, M., Han, S., Hu, S., Li, Y., Yu, Z., Liu, Y., Liang, X., Chen, Z.-J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26679734
Additional file 1 of Effect of the spatial–temporal specific theca cell Cyp17 overexpression on the reproductive phenotype of the novel TC17 mouse
Secchi, C., Belli, M., Harrison, T. N. H., Swift, J., Ko, C. J., Dulęba, A. J., Stupack, D., Chang, R. J., & Shimasaki, S. (2021) · Figshare · doi:10.6084/m9.figshare.16821538
Additional file 1 of Effect of melatonin supplementation on cardiometabolic risk factors, oxidative stress and hormonal profile in PCOS patients: a systematic review and meta-analysis of randomized clinical trials
Ziaei, S., Hasani, M., Malekahmadi, M., Daneshzad, E., Kadkhodazadeh, K., & Heshmati, J. (2024) · Figshare · doi:10.6084/m9.figshare.26182176
EFFICACY OF INOSITOLS IN POLYCYSTIC OVARY SYNDROME AND GESTATIONAL DIABETES MELLITUS: ANALYSIS OF PATHOGENETIC AND CLINICAL DATA
Druzhinina, A. A., Gyulakhmedova, S. M., Alyautdina, O. S., Bashokouh, F., Eliseeva, E. M., & Chistokhina, A. A. (2026) · Avicenna Bulletin · doi:10.25005/2074-0581-2026-28-1-122-139
“На более поздних стадиях повышенная концентрация андроге - нов, напротив, может спровоцировать атрезию фолликулов и ано - вуляцию [33, 34].”
Metabolic profiling of human follicular fluid to unravel the pathways involved in polycystic ovary syndrome – a systematic review
Moreira, M. V., Guerra‐Carvalho, B., Vale-Fernandes, E., Pignatelli, D., Bernardino, R. L., & Monteiro, M. P. (2026) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-026-10055-4
“Hyperandrogenism, one of the most consistent features of PCOS, characterized by elevated levels of circulating and intra-ovarian androgens, is largely attributed to intrinsic theca-cell dysfunction [25, 26].”

Authors: Gilling‐Smith, C., Story, H., Rogers, V., & Franks, S.
Affiliations: St Mary's Hospital (GB)
Corresponding author: Gilling‐Smith, C.
ORCID: Franks, S.
Venue: Clinical Endocrinology
Publisher: Wiley
Published: 1997-07
Volume: 47
Issue: 1
Pages: 93-99
ISSN: 0300-0664 (ISSN-L)
1365-2265
DOI: 10.1046/j.1365-2265.1997.2321049.x
OpenAlex: W2141227160
Cited by: 301
References: 0
Citations by year: 2026: 3 · 2025: 11 · 2024: 11 · 2023: 5 · 2022: 15 · 2021: 10 · 2020: 8 · 2019: 12 · 2018: 8 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 13 · 2013: 16 · 2012: 16
FWCI: 8.74
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2311 d)
Locations: Clinical Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Bayer Corporation
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: polycystic ovary syndrome, hCG stimulation test, 17-hydroxyprogesterone, GnRH analogues, LH suppression, androstenedione, testosterone, dehydroepiandrosterone sulfate, hirsutism, anovulation
MeSH terms: Adolescent, Adult, Androstenedione, Female, Chorionic Gonadotropin, Gonadotropins, Pituitary, Humans, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Middle Aged, Polycystic Ovary Syndrome, Gonadal Steroid Hormones, Testosterone, Theca Cells, Dehydroepiandrosterone Sulfate, 17-alpha-Hydroxyprogesterone

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks