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Cited by 95Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsGenetic and Kidney Cyst Diseases

Adolescent girls with polycystic ovary syndrome showing different phenotypes have a different metabolic profile associated with increasing androgen levels

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Fruzzetti, Franca, Perini, Daria, Lazzarini, Veronica, Parrini, Donatella, Genazzani, Andrea R.·2009·Fertility and Sterility
DOI 10.1016/j.fertnstert.2008.06.004
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Abstract

Objective To evaluate the metabolic profiles of adolescents with different phenotypes of polycystic ovary syndrome (PCOS).Design Observational study.Setting University outpatient clinic.Patient(s) Adolescents with PCOS (n = 120) were divided into four groups: oligomenorrhea and hirsutism (O-H, n = 50), oligomenorrhea, hirsutism, and polycystic ovaries (PCO-O-H, n = 22), oligomenorrhea, hirsutism, and hyperandrogenemia (A-O-H, n = 28), oligomenorrhea, and hirsutism, hyperandrogenemia, and polycystic ovaries (PCO-A-O-H, n = 20). A control group of age-matched adolescents (n = 30) was included.Intervention(s) Subjects underwent physical and ultrasound evaluations; fasting blood samples were taken for the measurement of endocrine and metabolic parameters.Main outcome measure(s) The endocrine and metabolic profiles were evaluated.Result(s) Adolescents with PCOS showed reduced insulin sensitivity and dyslipidemia. Triglycerides, and total and low-density lipoprotein cholesterol were higher in the phenotypes with hyperandrogenemia. Insulin resistance and body mass index were not significantly different between PCOS phenotypes. Triglyceride positively and high-density lipoportein cholesterol levels negatively correlated with free testosterone and free androgen index.Conclusion(s) The risk of metabolic alterations may vary in adolescent PCOS patients with different phenotypes. Hyperandrogenemia is a risk factor for dyslipidemia. This information may be of relevance in counseling adolescents with PCOS.

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Crossref · 10.1016/j.fertnstert.2008.06.004

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48 of 48 references verified0 citation errors · 0 not checkable

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  • Dyslipidemia is common in PCOS and is estimated to occur in 70% of those with PCOS.

    “Dyslipidemia is common in PCOS and is estimated to occur in 70% of those with PCOS.73, 74, 75, 76”

    From Increased Prevalence of Adverse Health Outcomes Across the Lifespan in Those Affected by Polycystic Ovary Syndrome: A Canadian Population Cohort (2024) · cites this paper as [75]

    The introductory passage describes dyslipidemia as a metabolic abnormality in many patients with PCOS, and the Results report lipid differences in adolescents with PCOS. Neither passage gives a 70% prevalence estimate, so the numerical part of the claim is unsupported by this paper. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Those with PCOS have a more adverse fasting lipid profile, positively associated with hyperandrogenemia, independent of obesity.

    “We and others have reported that those with PCOS have a more adverse fasting lipid profile, and this is positively associated with hyperandrogenemia, independent of obesity.73, 74, 75,77, 78, 79”

    From Increased Prevalence of Adverse Health Outcomes Across the Lifespan in Those Affected by Polycystic Ovary Syndrome: A Canadian Population Cohort (2024) · cites this paper as [75]

    The Results and Discussion (page unavailable) report adverse lipid measures in adolescents with PCOS, especially in phenotypes with hyperandrogenemia. The Discussion says the androgen–lipid association *seems* independent of weight; the citing sentence states that independence without qualification and applies the finding to people with PCOS generally, while this study examined adolescents. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

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Cites

1 retracted

Flagged first, then by citations

Research works printed but not linked: 2

  1. Cole TJ. The LMS method for constructing normalized growth stan- dards. Eur J Clin Nutr 1990;44:45-60.
  2. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentra- tions of low density lipoprotein cholesterol without use of preparative ul- tracentrifuge. Clin Chem 1972;18:499-502.

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Authors
Fruzzetti, F., Perini, D., Lazzarini, V., Parrini, D., & Genazzani, A. R.
Affiliations
University of Pisa (IT)
Corresponding author
Fruzzetti, Franca
ORCID
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2009-08
Volume
92
Issue
2
Pages
626-634
ISSN
0015-0282 (ISSN-L)
DOI
10.1016/j.fertnstert.2008.06.004
OpenAlex
W2015476724
Cited by
95
References
48
Citations by year
2026: 4 · 2025: 1 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 7 · 2016: 5 · 2015: 3 · 2014: 3 · 2013: 7 · 2012: 12
FWCI
7.34
Type
journal article
Language
en
Open access
Licence
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords
polycystic ovary syndrome, adolescent girls, PCOS phenotypes, hyperandrogenemia, metabolic profile, dyslipidemia, insulin resistance, triglycerides, HDL cholesterol, free testosterone, free androgen index, oligomenorrhea, hirsutism, body mass index
MeSH terms
Adolescent, Androgens, Child, Female, Humans, Insulin, Cholesterol, LDL, Polycystic Ovary Syndrome, Young Adult

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