The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
The evolution of β‐cell dysfunction and insulin resistance in type 2 diabetes
Abstract
Insulin resistance and β‐cell dysfunction have important roles in the pathogenesis and evolution of type 2 diabetes. The development of precise methods to measure these factors has helped us to define the relationship between them and evidence is reviewed that changes in insulin sensitivity are compensated by inverse changes in β‐cell responsiveness such that the product of insulin sensitivity and insulin secretion (the disposition index) remains constant. While the disposition index promises to be a useful tool to predict individuals at high risk of developing type 2 diabetes, other factors that contribute to β‐cell dysfunction and mark disease onset and progression include impairments in proinsulin processing and insulin secretion, decreased β‐cell mass and islet amyloid deposition. Emerging data indicate that anti‐diabetic agents, such as the thiazolidinediones that simultaneously target insulin resistance and β‐cell dysfunction, may have a beneficial impact on disease onset and progression. Several landmark clinical studies are underway to investigate if their initial promise is supported by data from large‐scale trials.
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Cites
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Kahn, S. E., Prigeon, R. L., McCulloch, D. K., Boyko, E. J., Bergman, R. N., Schwartz, M. W., Neifing, J. L., Ward, W. K., Beard, J. C., & Palmer, J. P. (1993) · Diabetes · doi:10.2337/diab.42.11.1663 · Cited by 1,405
Self-citationFatty acid-induced β cell apoptosis: A link between obesity and diabetes
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Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*
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Cited by
DeFronzo, R. A. (2009) · Diabetes · doi:10.2337/db09-9028 · Cited by 3,016
Diamanti-Kandarakis, E., & Dunaif, A. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1034 · Cited by 1,947
Pathogenesis of type 2 diabetes mellitus
DeFronzo, R. A. (2004) · Medical Clinics of North America · doi:10.1016/j.mcna.2004.04.013 · Cited by 1,342
Abdul-Ghani, M. A., Tripathy, D., & DeFronzo, R. A. (2006) · Diabetes Care · doi:10.2337/dc05-2179 · Cited by 744
Raz, I., Hanefeld, M., Xu, L., Caria, C., Williams-Herman, D., Khatami, H., & Sitagliptin Study 023 Group (2006) · Diabetologia · doi:10.1007/s00125-006-0416-z · Cited by 614
Metadata
- Authors
- Bergman, R. N., Finegood, D. T., & Kahn, S. E.
- Venue
- European Journal of Clinical Investigation
- Publisher
- Wiley
- Published
- 2002-05-16
- Volume
- 32
- Issue
- s3
- Pages
- 35-45
- ISSN
- 0014-2972 (ISSN-L)
- 1365-2362
- OpenAlex
- W1993930772
- Cited by
- 301
- References
- 31
- FWCI
- 12.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bergman, R. N., Finegood, D. T., & Kahn, S. E. (2002). The evolution of β‐cell dysfunction and insulin resistance in type 2 diabetes. European Journal of Clinical Investigation. https://doi.org/10.1046/j.1365-2362.32.s3.5.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
