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Cited by 301

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

The evolution of β‐cell dysfunction and insulin resistance in type 2 diabetes

Bergman, R. N., Finegood, D. T., Kahn, S. E.·2002·European Journal of Clinical Investigation
DOI 10.1046/j.1365-2362.32.s3.5.x
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Abstract

Insulin resistance and β‐cell dysfunction have important roles in the pathogenesis and evolution of type 2 diabetes. The development of precise methods to measure these factors has helped us to define the relationship between them and evidence is reviewed that changes in insulin sensitivity are compensated by inverse changes in β‐cell responsiveness such that the product of insulin sensitivity and insulin secretion (the disposition index) remains constant. While the disposition index promises to be a useful tool to predict individuals at high risk of developing type 2 diabetes, other factors that contribute to β‐cell dysfunction and mark disease onset and progression include impairments in proinsulin processing and insulin secretion, decreased β‐cell mass and islet amyloid deposition. Emerging data indicate that anti‐diabetic agents, such as the thiazolidinediones that simultaneously target insulin resistance and β‐cell dysfunction, may have a beneficial impact on disease onset and progression. Several landmark clinical studies are underway to investigate if their initial promise is supported by data from large‐scale trials.

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Metadata

Authors
Bergman, R. N., Finegood, D. T., & Kahn, S. E.
Venue
European Journal of Clinical Investigation
Publisher
Wiley
Published
2002-05-16
Volume
32
Issue
s3
Pages
35-45
ISSN
  • 0014-2972 (ISSN-L)
  • 1365-2362
DOI
10.1046/j.1365-2362.32.s3.5.x
OpenAlex
W1993930772
Cited by
301
References
31
FWCI
12.10
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.