Interleukin‐10 modulates susceptibility in experimental cerebral malaria
Open accessAbstract
In this study, we examined the effects of interleukin‐10 (IL‐10) on the outcome of experimental cerebral malaria (CM), a lethal neurological syndrome that occurs in susceptible strains of mice after infection with Plasmodium berghei ANKA (PbA). Constitutive IL‐10 mRNA levels were significantly higher in the spleen and brain of resistant animals. In vivo neutralization of endogenous IL‐10 in CM‐resistant mice induced the neurological syndrome in 35·7% of these mice, as opposed to 7·7% in controls. IL‐10 inhibited PbA antigen‐specific interferon‐ & gamma; (IFN‐ & gamma;) production in vitro but not tumour necrosis factor (TNF) serum levels in vivo . Susceptible mice, on the other hand, were significantly protected against CM when injected with recombinant IL‐10. Overall, our findings suggest that IL‐10 plays a protective role against experimental cerebral malaria.
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IL-10 has been proposed as a biomarker of placental infection and as a definitive marker of inflammation during placental malaria.
“Other authors, based on high levels detected in serum of women with gestational malaria, have proposed IL-10 as biomarker of placental infection [33] and a definitive marker of inflammation during placental malaria [34].”
From Submicroscopic infection of placenta by Plasmodium produces Th1/Th2 cytokine imbalance, inflammation and hypoxia in women from north-west Colombia (2014) · cites this paper as [33]
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- Authors
- KOSSODO, S., MONSO, C., JUILLARD, P., VELU, T., GOLDMAN, M., & GRAU, G. E.
- Affiliations
- University of Geneva (CH)
- Université Libre de Bruxelles (BE)
- Corresponding author
- KOSSODO, S.
- Venue
- Immunology
- Publisher
- Wiley
- Published
- 1997-08
- Volume
- 91
- Issue
- 4
- Pages
- 536-540
- ISSN
- 0019-2805 (ISSN-L)
- 1365-2567
- PMC
- PMC1363872
- OpenAlex
- W2000697302
- Cited by
- 180
- References
- 31
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 8 · 2021: 4 · 2020: 3 · 2019: 9 · 2018: 4 · 2017: 7 · 2016: 6 · 2015: 9 · 2014: 15 · 2013: 8 · 2012: 9
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Funders
- World Health Organization
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Keywords
- IL-10, experimental cerebral malaria, Plasmodium berghei ANKA, interferon-gamma, TNF-α, neuroprotection, host resistance, mouse strain differences
- MeSH terms
- Animals, Disease Susceptibility, Interferon-gamma, Mice, Inbred BALB C, Mice, Inbred CBA, Plasmodium berghei, Recombinant Proteins, RNA, Messenger, Tumor Necrosis Factor-alpha, Gene Expression, Interleukin-10, Malaria, Cerebral, Mice
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