The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Antioxidant status in delayed healing type of wounds
Open accessAbstract
This investigation studied the contribution of antioxidants in delaying healing in excision cutaneous wounds (8 mm) in diabetic, aged and immunocompromised animals. Skin levels of catalase, glutathione (GSH), ascorbic acid (AA) and vitamin E in streptozotocin‐induced diabetic rat were lower as compared to nondiabetics. The 7‐d wound tissue of diabetic rats showed an increased vitamin E level along with depleted GSH content. In aged rats (18 months old), higher levels of skin superoxide dismutase (SOD), glutathione peroxidase (Gpx) and thiobarbituric acid reactive substances (TBARS) and lower levels of catalase and GSH were found as compared to their values in young rats (3–4 months old). The levels of SOD, GPx, catalase, AA, GSH and vitamin E in 7‐d wound tissue of aged rats were significantly lower in comparison to those in young rats. However, TBARS were elevated in these wound tissues. The non‐wounded skin of immunocompromised (athymic) mice showed lower levels of SOD, catalase, and TBARS and higher GSH and GPx levels in comparison to those present in normal mouse skin. Surprisingly, the analysis of 7‐d wound tissue showed higher levels of SOD, catalase, GPx, and GSH and lower TBARS level in athymic mice compared to the wound tissue of normal mice. Thus low levels of antioxidants accompanied by raised levels of markers of free radical damage play a significant role in delaying wound healing in aged rats. In diabetic rats reduced glutathione levels may have a contributory role in delaying the healing process. However, in immunocompromised mice the antioxidant status following injury showed an adapted response.
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Shukla, A., Rasik, A. M., & Patnaik, G. K. (1997) · Free Radical Research · doi:10.3109/10715769709097788 · Cited by 195 · cited 2×
“Free radicals and their scavenging systems are also known to play a very important role in healing of normal and delayed healing types of wounds (Hallberg et al. 1996; Shukla et al. 1997; McDaniel et al. 1998).”
BackgroundMethodImmune Aspects of Wound Repair
Barbul, A. (1990) · Clinics in Plastic Surgery · doi:10.1016/s0094-1298(20)30618-0 · Cited by 111 · cited 2×
“The immune system plays a very important role in healing (Barbul 1990; Lowry 1993).”
Background
Cited by
Oxidative stress in normal and impaired wound repair
SCHAFER, M., & WERNER, S. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.06.004 · Cited by 902
The molecular biology of chronic wounds and delayed healing in diabetes
Blakytny, R., & Jude, E. (2006) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.01773.x · Cited by 632
Redox Control of the Cell Cycle in Health and Disease
Sarsour, E. H., Kumar, M. G., Chaudhuri, L., Kalen, A. L., & Goswami, P. C. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2513 · Cited by 381
Chigurupati, S., Mughal, M. R., Okun, E., Das, S., Kumar, A., McCaffery, M., Seal, S., & Mattson, M. P. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2012.11.061 · Cited by 377
Ayuk, S. M., Abrahamse, H., & Houreld, N. N. (2016) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/j.jphotobiol.2016.05.027 · Cited by 346
Metadata
- Authors
- Rasik, A. M., & Shukla, A.
- Venue
- International Journal of Experimental Pathology
- Publisher
- Wiley
- Published
- 2000-08
- Volume
- 81
- Issue
- 4
- Pages
- 257-263
- ISSN
- 0959-9673 (ISSN-L)
- 1365-2613
- OpenAlex
- W1502331067
- Cited by
- 190
- References
- 2
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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