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Cited by 381

The DOI matches its Crossref record; 354 of the 354 references it cites were found in a registry or an index.

Redox Control of the Cell Cycle in Health and Disease

Open access
Sarsour, Ehab H., Kumar, Maneesh G., Chaudhuri, Leena, Kalen, Amanda L., Goswami, Prabhat C.·2009·Antioxidants & Redox Signaling
DOI 10.1089/ars.2009.2513
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Abstract

The cellular oxidation and reduction (redox) environment is influenced by the production and removal of reactive oxygen species (ROS). In recent years, several reports support the hypothesis that cellular ROS levels could function as ''second messengers'' regulating numerous cellular processes, including proliferation. Periodic oscillations in the cellular redox environment, a redox cycle, regulate cell-cycle progression from quiescence (G(0)) to proliferation (G(1), S, G(2), and M) and back to quiescence. A loss in the redox control of the cell cycle could lead to aberrant proliferation, a hallmark of various human pathologies. This review discusses the literature that supports the concept of a redox cycle controlling the mammalian cell cycle, with an emphasis on how this control relates to proliferative disorders including cancer, wound healing, fibrosis, cardiovascular diseases, diabetes, and neurodegenerative diseases. We hypothesize that reestablishing the redox control of the cell cycle by manipulating the cellular redox environment could improve many aspects of the proliferative disorders.

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Metadata

Authors
Sarsour, E. H., Kumar, M. G., Chaudhuri, L., Kalen, A. L., & Goswami, P. C.
Venue
Antioxidants & Redox Signaling
Publisher
SAGE Publications
Published
2009-12
Volume
11
Issue
12
Pages
2985-3011
ISSN
  • 1523-0864 (ISSN-L)
  • 1557-7716
DOI
10.1089/ars.2009.2513
OpenAlex
W2026365242
Cited by
381
References
354
FWCI
9.00
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Redox Control of the Cell Cycle in Health and Disease. https://app.cochat.ai/papers/10.1089/ars.2009.2513
The paper
Sarsour, E. H., Kumar, M. G., Chaudhuri, L., Kalen, A. L., & Goswami, P. C. (2009). Redox Control of the Cell Cycle in Health and Disease. Antioxidants & Redox Signaling. https://doi.org/10.1089/ars.2009.2513

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.