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Anti-cancer function of phytic acid
Abstract
Inositol hexaphosphate (InsP6 a.k.a. phytic acid or IP6) is ubiquitous. In the plant kingdom it is particularly abundant in cereals and legumes; in much smaller amounts IP6 and its lower phosphorylated forms (IP(1-5)) are contained in most mammalian cells, where they are important in regulating vital cellular functions. Both in vivo and in vitro experiments have demonstrated striking anticancer (preventive as well as therapeutic) effects of IP6. Inositol also is anti-carcinogenic, albeit to a lesser extent; it acts synergistically IP6 in inhibiting cancer. In addition to reduction in cell proliferation, IP6 increases differentiation of malignant cells often resulting in reversion to the normal phenotype. IP6 is quickly absorbed from the rat stomach and upper intestine and distributed as inositol and IP1. In vitro, it is instantaneously taken up by malignant cells undergoing variable dephosphorylation to inositol and IP(1-5), pointing towards their role in mediating the action of IP6. In humans, IP6 has recently been detected in urine, plasma and other biological fluids; the levels fluctuating with ingestion or deprivation of IP6 or IP6-rich diet. As IP6 is high in high-fibre diets, these also may explain, at least in part, the epidemiological observation showing the association of ingesting high-fibre diets with a lower incidence of certain cancers. Along with safety, the reproducible efficacy of IP6 and inositol in the prevention of cancer in laboratory animals warrant their…
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“Phytic acid may also be beneficial by reducing the bioavailability of toxic heavy metals such as cadmium and lead, and reducing excessive oxidation activity of iron and copper through chelation (66) .”
From Protein quality evaluation twenty years after the introduction of the protein digestibility corrected amino acid score method (2012) · cites this paper as [66]
In the citing paper
“Phytic acid may also be beneficial by reducing the bioavailability of toxic heavy metals such as cadmium and lead, and reducing excessive oxidation activity of iron and copper through chelation (66) .”
From Protein quality evaluation twenty years after the introduction of the protein digestibility corrected amino acid score method (2012) · cites this paper as [66]
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“However, the consistent negative correlation between those high-fibre diets rich in IP6, and cancers of the colon, breast and perhaps prostate are interesting (Englyst et al., 1982; Yu et al., 1991; Willett, 1994).”
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“Hence, phytate has shown to decrease cancer biomarkers of colon, liver, lung, prostate, breast, skin and soft tissue carcinogenesis in rats and/or mice (Jenab and Thompson 1998; Jenab and Thompson 2000; Shamsuddin 2002; Vucenik and Shamsuddin 2004).”
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“Phytic acid, known for its potent antioxidant and anti-cancer properties 16, 17 , has an unexplored role in HCV-derived hepatocellular carcinoma.”
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Cell Signaling Properties of Inositol Hexaphosphate (IP6)
Shamsuddin, A. M. (2005) · Oxidative stress and disease · doi:10.1201/9781420028096.ch19 · Cited by 2
Self-citationAssessment of the analgesic potential of ethylacetate leaf fraction of Sida linifolia L. (Malvaceae)
Ezeako, E. C., Solomon, A. Y., Ngozi, H., Ajagbe͓, A., Agwu, L. O., Michael, L., Odoh, E. C., Olaoye, V. I., Ashiakpa, P. N., Nworie, M. B., et al. (2023) · International Journal of Plant Based Pharmaceuticals · doi:10.29228/ijpbp.36
“On the contrary, recent submissions have posited that phytate in modest amounts may exert antioxidant and anticancer effects and could prevent kidney stone formation caused by calcium oxalate (Pires et al., 2023; Pujol et al., 2023; Shamsuddin, 2002).”
BackgroundMelini, V., & Melini, F. (2021) · A Centum of Valuable Plant Bioactives · doi:10.1016/b978-0-12-822923-1.00005-4
The Wheat-Kernel Ingredients with Dichotomic Physiological Activities
Dror, Y., Rimon, E., & Vaida, R. (2020) · Whole-Wheat Bread for Human Health · doi:10.1007/978-3-030-39823-1_12
Mondor, M. (2020) · Springer eBooks · doi:10.1007/978-3-030-41376-7_14 · Cited by 9
Admassu, S. (2008) · doi:10.4314/ejst.v5i2
“In vitro studies of both human and rodents’ cancer cell lines in research laboratory demonstrate that phytic acid reduces cell proliferation rate in all of the cell lines tested (Shamsuddin, 2002).”
Molecular study of beta propeller phytases
Cheng, C.-W. (2005) · doi:10.5353/th_b3638780
Metadata
- Authors
- Shamsuddin, A. M.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- Shamsuddin, Abulkalam M
- Venue
- International Journal of Food Science and Technology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-09-23
- Volume
- 37
- Issue
- 7
- Pages
- 769-782
- ISSN
- 0950-5423 (ISSN-L)
- 1365-2621
- OpenAlex
- W2099176354
- Cited by
- 182
- References
- 74
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 2 · 2023: 13 · 2022: 9 · 2021: 9 · 2020: 9 · 2019: 3 · 2018: 8 · 2017: 17 · 2016: 9 · 2015: 8 · 2014: 9 · 2013: 9 · 2012: 15
- FWCI
- 7.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Journal of Food Science & Technology (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytase and its Applications
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- phytic acid, myo-inositol, anticancer activity, cancer prevention, cancer therapy, cell differentiation, cell proliferation, high-fiber diet, dietary intake, cereals, Fabaceae
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