Conjugated linoleic acid biosynthesis by human-derived Bifidobacterium species
Abstract
AIMS: To assess strains of Lactobacillus, Lactococcus, Pediococcus and Bifidobacterium for their ability to produce the health-promoting fatty acid conjugated linoleic acid (CLA) from free linoleic acid. METHODS AND RESULTS: In this study, strains of Lactobacillus, Lactococcus, Pediococcus and Bifidobacterium were grown in medium containing free linoleic acid. Growth of the bacteria in linoleic acid and conversion of the linoleic acid to CLA was assessed. Of the bacteria assessed, nine strains of Bifidobacterium produced the c9, t11 CLA isomer from free linoleic acid. The t9, t11 CLA isomer was also produced by some strains, but at much lower concentrations. CONCLUSIONS: The production of CLA by bifidobacteria exhibited considerable interspecies variation. Bifidobacterium breve and B. dentium were the most efficient CLA producers among the range of strains tested, with B. breve converting up to 65% linoleic acid to c9, t11 CLA when grown in 0.55 mg ml(-1) linoleic acid. Strains also varied considerably with respect to their sensitivity to linoleic acid. SIGNIFICANCE AND IMPACT OF THE STUDY: The production of CLA by probiotic bifidobacteria offers a possible mechanism for some health-enhancing properties of bifidobacteria and provides novel opportunities for the development of functional foods.
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The t9,t11 C18:2 isomer has potent growth inhibitory and antiproliferative effects on human colon and breast cancer cells.
“The trans-9, trans-11 C18:2 isomer also has potent growth inhibitory and antiproliferative effects on the growth of human colon and breast cancer cells [259,260].”
From Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions (2022) · cites this paper as [259]
Different bacteria produce different ratios of CLA isomers.
“Different bacteria produce different ratios of CLA isomers [25, 26]”
From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [25]
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References 55 · Cited by 299
- Authors
- Coakley, M., Ross, R. P., Nordgren, M., Fitzgerald, G., Devery, R., & Stanton, C.
- Affiliations
- Teagasc - The Irish Agriculture and Food Development Authority (IE)
- University College Cork (IE)
- Dublin City University (IE)
- Venue
- Journal of Applied Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-01
- Volume
- 94
- Issue
- 1
- Pages
- 138-145
- ISSN
- 1364-5072 (ISSN-L)
- 1365-2672
- OpenAlex
- W2171772502
- Cited by
- 299
- References
- 55
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 10 · 2023: 9 · 2022: 12 · 2021: 10 · 2020: 12 · 2019: 13 · 2018: 14 · 2017: 10 · 2016: 16 · 2015: 11 · 2014: 20 · 2013: 12 · 2012: 14
- FWCI
- 15.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- conjugated linoleic acid, Bifidobacterium, linoleic acid conversion, c9,t11-CLA, Bifidobacterium breve, Bifidobacterium dentium, probiotic bacteria, functional foods, bacterial strain variation
- MeSH terms
- Adult, Bifidobacterium, Chromatography, Gas, Culture Media, Fatty Acids, Feces, Humans, Infant, Intestines, Isomerism, Lactobacillus, Pediococcus, Lactococcus, Linoleic Acid, Probiotics
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