Use of the atypical antipsychotics Olanzapine and Risperidone in adults with intellectual disability
Abstract
The present study was designed to monitor the use of atypical antipsychotics in adults with intellectual disability and to evaluate the clinical effectiveness of these drugs. Twenty‐one patients were commenced on an atypical antipsychotic: 12 on Olanzapine and nine on Risperidone. The ICD‐10 diagnoses of the subjects were mild (13 cases) or moderate (8 cases) mental retardation, and psychiatric disorders (17 cases) with significant impairment of behaviour in 10 cases. Tolerability was good for 15 patients experiencing minimum or no side‐effects, and medication was only stopped as a result of side‐effects in one case. Clinical global outcome was rated as minimally improved or better for 16 cases. The present findings suggest that the atypical antipsychotics Olanzapine and Risperidone are well tolerated by patients with intellectual disability and psychiatric disorders, and are broadly effective against target symptoms.
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Randomized controlled trials of risperidone in individuals with ASD found significant reductions in challenging behaviors, such as irritability and hyperactivity.
“randomized controlled trials of risperidone in individuals with ASD found significant reductions in challenging behaviors, such as irritability and hyperactivity [596-600]”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [600]
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“For example, antipsychotics have been used to target co-morbid psychiatric symptoms and aggression in adults with MR (Williams et al. 2000).”
Background
- Authors
- Williams, H., Clarke, R., Bouras, N., Martin, J., & Holt, G.
- Affiliations
- Guy's Hospital (GB)
- Corresponding author
- Holt, G.
- ORCID
- Holt, G.
- Venue
- Journal of Intellectual Disability Research
- Publisher
- Wiley
- Published
- 2000-04
- Volume
- 44
- Issue
- 2
- Pages
- 164-169
- ISSN
- 0964-2633 (ISSN-L)
- 1365-2788
- OpenAlex
- W1558287329
- Cited by
- 45
- References
- 11
- Citations by year
- 2024: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2016: 3 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Intellectual Disability Research (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
- Keywords
- atypical antipsychotics, olanzapine, risperidone, intellectual disability, adults with intellectual disabilities, mental illness, behavioural impairment, tolerability, adverse drug reactions, clinical effectiveness, antipsychotic treatment outcomes
- MeSH terms
- Olanzapine, Adult, Benzodiazepines, Dose-Response Relationship, Drug, Female, Follow-Up Studies, Humans, Male, Intellectual Disability, Middle Aged, Pirenzepine, Prospective Studies, Psychotic Disorders, Surveys and Questionnaires, Severity of Illness Index, Antipsychotic Agents, Treatment Outcome, Risperidone, Mood Disorders
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