The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Lamivudine treatment during pregnancy to prevent perinatal transmission of hepatitis B virus infection
Abstract
Summary. Vertical transmission of hepatitis B virus (HBV) can occur occasionally despite vaccination of the child. This vaccination breakthrough has been associated with high maternal viraemia. We treated eight highly viraemic (HBV‐DNA ≥ 1.2 × 10 9 geq/mL) mothers with 150 mg of lamivudine daily during the last month of pregnancy. HBV‐DNA, hepatitis B surface antigen (HBsAg), anti‐HBs and anti‐HBc of their offspring were measured at birth and at 3, 6 and 12 months, respectively. Twenty‐four children, born to untreated HBsAg‐positive mothers with HBV‐DNA levels ≥1.2 × 10 9 geq/mL served as historical controls. All children received passive‐active immunization at birth and were followed‐up for 12 months. In the lamivudine group one of the eight children (12.5%) was still HBsAg and HBV‐DNA positive at the age of 12 months. All other children seroconverted to anti‐HBs and maintained seroprotection. In three children, HBV‐DNA was temporarily detected by polymerase chain reaction. In the untreated historical control group, perinatal transmission occurred in seven of 25 children (28%). In highly viraemic HBsAg‐positive mothers, reduction of viraemia by lamivudine therapy in the last month of pregnancy may be an effective and safe measure to reduce the risk of child vaccination breakthrough. This approach should be evaluated in a large controlled trial.
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A One-Year Trial of Lamivudine for Chronic Hepatitis B
Lai, C.-L., Chien, R.-N., Leung, N. W. Y., Chang, T.-T., Guan, R., Tai, D.-I., Ng, K.-Y., Wu, P.-C., Dent, J. C., Barber, J., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199807093390201 · Cited by 1,754
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Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues
Blanche, S., Tardieu, M., Rustin, P., Slama, A., Barret, B., Firtion, G., Ciraru-Vigneron, N., Lacroix, C., Rouzioux, C., Mandelbrot, L., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(99)07219-0 · Cited by 661
Lamivudine-Zidovudine Combination for Prevention of Maternal-Infant Transmission of HIV-1
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Long-term therapy of chronic hepatitis B with lamivudine
Lau, D. T.-Y., Khokhar, F. M., Doo, E., Ghany, M. G., Herion, D., Park, Y., Kleiner, D. E., Schmid, P., Condreay, L. D., Gauthier, J., et al. (2000) · Hepatology · doi:10.1053/jhep.2000.17912 · Cited by 348
Antiretroviral therapies in pregnancy
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Cited by
Side effects of long-term oral antiviral therapy for hepatitis B
Fontana, R. J. (2009) · Hepatology · doi:10.1002/hep.22885 · Cited by 272
Hepatitis B vaccination: The key towards elimination and eradication of hepatitis B
Chen, D.-S. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.01.002 · Cited by 261
Chen, H., Lee, C., Chang, C., Ni, Y., Shyu, M., Chen, S., Hu, J., Lin, H. H., Zhao, L., Mu, S., et al. (2015) · Hepatology · doi:10.1002/hep.27837 · Cited by 255
Metadata
- Authors
- van Zonneveld, M., van Nunen, A. B., Niesters, H. G. M., de Man, R. A., Schalm, S. W., & Janssen, H. L. A.
- Venue
- Journal of Viral Hepatitis
- Publisher
- Wiley
- Published
- 2003-06-23
- Volume
- 10
- Issue
- 4
- Pages
- 294-297
- ISSN
- 1352-0504 (ISSN-L)
- 1365-2893
- OpenAlex
- W2019630600
- Cited by
- 289
- References
- 15
- FWCI
- 10.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- van Zonneveld, M., van Nunen, A. B., Niesters, H. G. M., de Man, R. A., Schalm, S. W., & Janssen, H. L. A. (2003). Lamivudine treatment during pregnancy to prevent perinatal transmission of hepatitis B virus infection. Journal of Viral Hepatitis. https://doi.org/10.1046/j.1365-2893.2003.00440.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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