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Cited by 499

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

A novel regulatory system required for pathogenicity of Xanthomonas campestris is mediated by a small diffusible signal molecule

Open access
Barber, C. E., Tang, J. L., Feng, J. X., Pan, M. Q., Wilson, T. J. G., Slater, H., Dow, J. M., Williams, P., Daniels, M. J.·1997·Molecular Microbiology

Abstract

Mutations in the seven clustered rpf genes cause downregulated synthesis of extracellular enzymes and reduced virulence of Xanthomonas campestris pathovar campestris (Xcc). The phenotype of mutants in one of the genes, rpfF, can be restored by a diffusible extracellular factor (DSF) produced by all Xcc strains tested, apart from rpfF and rpfB mutants. DSF accumulates in early stationary phase (when synthesis of enzymes is maximal), but levels decline subsequently. Addition of DSF to exponentially‐growing wild‐type bacteria does not cause precocious enzyme synthesis. rpfB and rpfF are expressed throughout growth, but the rate increases in early stationary phase. RpfB is predicted to be a long‐chain fatty acyl CoA ligase, and RpfF shows some relatedness to enoyl CoA hydratases. The properties of DSF suggest that it may be a fatty‐acid derivative, and certain lipid preparations possess DSF activity at higher concentrations. These include lipid extracts and acid‐hydrolysed lipopolysaccharide and lipid A from Xcc, and purified dodecanoic and hydroxydodecanoic acid. DSF production is confined to certain xanthomonads. We propose a model for the DSF system, which represents a novel mechanism for regulating virulence factor synthesis in response to physiological or environmental changes.

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Crossref · 10.1046/j.1365-2958.1997.3721736.x

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Metadata

Authors
Barber, C. E., Tang, J. L., Feng, J. X., Pan, M. Q., Wilson, T. J. G., Slater, H., Dow, J. M., Williams, P., & Daniels, M. J.
Venue
Molecular Microbiology
Publisher
Wiley
Published
1997-05
Volume
24
Issue
3
Pages
555-566
ISSN
  • 0950-382X (ISSN-L)
  • 1365-2958
OpenAlex
W2162907250
Cited by
499
References
17
FWCI
11.32
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: A novel regulatory system required for pathogenicity of Xanthomonas campestris is mediated by a small diffusible signal molecule. https://app.cochat.ai/papers/10.1046/j.1365-2958.1997.3721736.x
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Barber, C. E., Tang, J. L., Feng, J. X., Pan, M. Q., Wilson, T. J. G., Slater, H., Dow, J. M., Williams, P., & Daniels, M. J. (1997). A novel regulatory system required for pathogenicity of Xanthomonas campestris is mediated by a small diffusible signal molecule. Molecular Microbiology. https://doi.org/10.1046/j.1365-2958.1997.3721736.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.