The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
TonB‐dependent iron acquisition: mechanisms of siderophore‐mediated active transport†
Abstract
Cells growing in aerobic environments have developed intricate strategies to overcome the scarcity of iron, an essential nutrient. In Gram‐negative bacteria, high‐affinity iron acquisition requires outer membrane‐localized proteins that bind iron chelates at the cell surface and promote their uptake. Transport of bound chelates across the outer membrane depends upon TonB–ExbB–ExbD, a cytoplasmic membrane‐localized complex that transduces energy from the proton motive force to high‐affinity receptors in the outer membrane. Upon ligand binding to iron chelate receptors, conformational changes are induced, some of which are detected in the periplasm. These structural alterations signal the ligand‐loaded status of the receptor and, therefore, the requirement for TonB‐dependent energy transduction. Thus, TonB interacts preferentially and directly with ligand‐loaded receptors. Such a mechanism ensures the productive use of cellular energy to drive active transport at the outer membrane.
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Nikaido, H. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.4.593-656.2003 · Cited by 4,316
A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics
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Siderophore-Mediated Iron Transport: Crystal Structure of FhuA with Bound Lipopolysaccharide
Ferguson, A. D., Hofmann, E., Coulton, J. W., Diederichs, K., & Welte, W. (1998) · Science · doi:10.1126/science.282.5397.2215 · Cited by 787
Self-citationBacterial coaggregation: an integral process in the development of multi-species biofilms
Rickard, A. H., Gilbert, P., High, N. J., Kolenbrander, P. E., & Handley, P. S. (2003) · Trends in Microbiology · doi:10.1016/s0966-842x(02)00034-3 · Cited by 765
Comparative Genomics of Thiamin Biosynthesis in Procaryotes
Rodionov, D. A., Vitreschak, A. G., Mironov, A. A., & Gelfand, M. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208965200 · Cited by 353
Metadata
- Authors
- Moeck, G. S., & Coulton, J. W.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 1998-05
- Volume
- 28
- Issue
- 4
- Pages
- 675-681
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W1567229177
- Cited by
- 302
- References
- 32
- FWCI
- 9.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- Moeck, G. S., & Coulton, J. W. (1998). TonB‐dependent iron acquisition: mechanisms of siderophore‐mediated active transport†. Molecular Microbiology. https://doi.org/10.1046/j.1365-2958.1998.00817.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
