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Cited by 386

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Bacillus subtilis contains multiple Fur homologues: identification of the iron uptake (Fur) and peroxide regulon (PerR) repressors

Bsat, Nada, Herbig, Andrew, Casillas‐Martinez, Lilliam, Setlow, Peter, Helmann, John D.·1998·Molecular Microbiology
DOI 10.1046/j.1365-2958.1998.00921.x
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Abstract

Fur (ferric uptake regulator) proteins control iron uptake in many Gram‐negative bacteria. Although Fur homologues have been identified in Gram‐positive bacteria, their roles in gene regulation are unknown. Genome sequencing has revealed three fur homologues in Bacillus subtilis: yqkL, yqfV and ygaG. We demonstrate that yqkL encodes an iron uptake repressor: both siderophore biosynthesis and transcription of ferri‐siderophore uptake genes is constitutive in the yqkL mutant. Thus, yqkL encodes a repressor that is functionally as well as structurally related to Fur. B. subtilis peroxide stress genes are induced by either H 2 O 2 or by metal ion limitation. Previous genetic studies defined a regulatory locus, perR, postulated to encode the peroxide regulon repressor. We demonstrate that a ygaG mutant has the perR phenotype: it is highly resistant to peroxides and overexpresses catalase, alkyl hydroperoxide reductase and the DNA binding protein MrgA. Nine spontaneous perR mutations, isolated by virtue of their ability to derepress mrgA transcription in the presence of manganous ion, all contain sequence changes in the ygaG locus and can be complemented by the cloned ygaG gene. Thus, ygaG encodes the peroxide regulon repressor and is allelic with perR.

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Metadata

Authors
Bsat, N., Herbig, A., Casillas‐Martinez, L., Setlow, P., & Helmann, J. D.
Venue
Molecular Microbiology
Publisher
Wiley
Published
1998-07
Volume
29
Issue
1
Pages
189-198
ISSN
  • 0950-382X (ISSN-L)
  • 1365-2958
DOI
10.1046/j.1365-2958.1998.00921.x
OpenAlex
W2072779885
Cited by
386
References
51
FWCI
11.95
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Bacillus subtilis contains multiple Fur homologues: identification of the iron uptake (Fur) and peroxide regulon (PerR) repressors. https://app.cochat.ai/papers/10.1046/j.1365-2958.1998.00921.x
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Bsat, N., Herbig, A., Casillas‐Martinez, L., Setlow, P., & Helmann, J. D. (1998). Bacillus subtilis contains multiple Fur homologues: identification of the iron uptake (Fur) and peroxide regulon (PerR) repressors. Molecular Microbiology. https://doi.org/10.1046/j.1365-2958.1998.00921.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.