The DOI matches its Crossref record; 35 of the 36 references it cites were found in a registry or an index.
Iron acquisition systems in the pathogenic Neisseria
Abstract
Pathogenic neisseriae have a repertoire of high‐affinity iron uptake systems to facilitate acquisition of this essential element in the human host. They possess surface receptor proteins that directly bind the extracellular host iron‐binding proteins transferrin and lactoferrin. Alternatively, they have siderophore receptors capable of scavenging iron when exogenous siderophores are present. Released intracellular haem iron present in the form of haemoglobin, haemoglobin–haptoglobin or free haem can be used directly as a source of iron for growth through direct binding by specific surface receptors. Although these receptors may vary in complexity and composition, the key protein involved in the transport of iron (as iron, haem or iron‐siderophore) across the outer membrane is a TonB‐dependent receptor with an overall structure presumably similar to that determined recently for Escherichia coli FhuA or FepA. The receptors are potentially ideal vaccine targets in view of their critical role in survival in the host. Preliminary pilot studies indicate that transferrin receptor‐based vaccines may be protective in humans.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Although it has not been characterized as well as the Tf receptor, the Lf receptor is believed to be an important meningococcal virulence factor [29].”
From Strategies of intracellular pathogens for obtaining iron from the environment (2015) · cites this paper as [29]
In the citing paper
“Some pathogens actively recruit TfR1 to the bacterium-containing vacuole [29, 45].”
From Strategies of intracellular pathogens for obtaining iron from the environment (2015) · cites this paper as [29]
Citations
Cites
Andrews, N. C. (1999) · New England Journal of Medicine · doi:10.1056/nejm199912233412607 · Cited by 2,130
Siderophore-Mediated Iron Transport: Crystal Structure of FhuA with Bound Lipopolysaccharide
Ferguson, A. D., Hofmann, E., Coulton, J. W., Diederichs, K., & Welte, W. (1998) · Science · doi:10.1126/science.282.5397.2215 · Cited by 787
Crystal structure of the outer membrane active transporter FepA from Escherichia coli.
Buchanan (1999) · Nature Structural Biology · doi:10.1038/4931 · Cited by 591
Transmembrane Signaling across the Ligand-Gated FhuA Receptor
Locher, K. P., Rees, B., Koebnik, R., Mitschler, A., Moulinier, L., Rosenbusch, J. P., & Moras, D. (1998) · Cell · doi:10.1016/s0092-8674(00)81700-6 · Cited by 540
Bacterial transferrin and lactoferrin receptors
Gray-Owen, S. D., & Schyvers, A. B. (1996) · Trends in Microbiology · doi:10.1016/0966-842x(96)10025-1 · Cited by 299
Schryvers, A. B., & Morris, L. J. (1988) · Infection and Immunity · doi:10.1128/iai.56.5.1144-1149.1988 · Cited by 244
Self-citationCornelissen, C. N., Kelley, M., Hobbs, M. M., Anderson, J. E., Cannon, J. G., Cohen, M. S., & Sparling, P. F. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00710.x · Cited by 235
Stojiljkovic, I., & Hantke, K. (1994) · Molecular Microbiology · doi:10.1111/j.1365-2958.1994.tb00465.x · Cited by 205
West, S. E. H., & Sparling, P. F. (1985) · Infection and Immunity · doi:10.1128/iai.47.2.388-394.1985 · Cited by 192
Anderson, J. E., Sparling, P. F., & Cornelissen, C. N. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.11.3162-3170.1994 · Cited by 188
Bruns, C. M., Nowalk, A. J., Arvai, A. S., McTigue, M. A., Vaughan, K. G., Mietzner, T. A., & McRee, D. E. (1997) · Nature Structural & Molecular Biology · doi:10.1038/nsb1197-919 · Cited by 177
Legrain, M., Mazarin, V., Irwin, S. W., Bouchon, B., Quentin-Millet, M. J., Jacobs, E. J., & Schryvers, A. B. (1993) · Gene · doi:10.1016/0378-1119(93)90348-7 · Cited by 155
Self-citationLewis, L. A., Gray, E., Wang, Y., Roe, B. A., & Dyer, D. W. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.2501619.x · Cited by 145
Stojiljkovic, I., Larson, J., Hwa, V, Anic, S., & So, M. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.15.4670-4678.1996 · Cited by 121
Chen, C., Berish, S. A., Morse, S. A., & Mietzner, T. A. (1993) · Molecular Microbiology · doi:10.1111/j.1365-2958.1993.tb01957.x · Cited by 117
Effects of serum carrier proteins on the growth of pathogenic neisseriae with heme-bound iron
Dyer, D. W., West, E. P., & Sparling, P. F. (1987) · Infection and Immunity · doi:10.1128/iai.55.9.2171-2175.1987 · Cited by 113
Lissolo, L., Maitre-Wilmotte, G., Dumas, P., Mignon, M., Danve, B., & Quentin-Millet, M. J. (1995) · Infection and Immunity · doi:10.1128/iai.63.3.884-890.1995 · Cited by 111
Irwin, S. W., Averill, N., Cheng, C. Y., & Schryvers, A. B. (1993) · Molecular Microbiology · doi:10.1111/j.1365-2958.1993.tb01657.x · Cited by 108
Self-citationStojiljković, I., & Srinivasan, N. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.3.805-812.1997 · Cited by 100
Chen, C.-J., Sparling, P. F., Lewis, L. A., Dyer, D. W., & Elkins, C. A. (1996) · Infection and Immunity · doi:10.1128/iai.64.12.5008-5014.1996 · Cited by 90
Phase Variation of Hemoglobin Utilization in Neisseria gonorrhoeae
Chen, C.-J., Elkins, C., & Sparling, P. F. (1998) · Infection and Immunity · doi:10.1128/iai.66.3.987-993.1998 · Cited by 84
Rokbi, B., Mignon, M., Maitre-Wilmotte, G., Lissolo, L., Danve, B., Caugant, D. A., & Quentin-Millet, M. J. (1997) · Infection and Immunity · doi:10.1128/iai.65.1.55-63.1997 · Cited by 84
Molecular characterization of LbpB, the second lactoferrin‐binding protein of Neisseria meningitidis
Pettersson, A. M., Prinz, T., Umar, A., van der Biezen, J., & Tommassen, J. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00707.x · Cited by 79
Retzer, M. D., Yu, R., Zhang, Y., Gonzalez, G. C., & Schryvers, A. B. (1998) · Microbial Pathogenesis · doi:10.1006/mpat.1998.0226 · Cited by 61
Self-citationPettersson, A. M., Klarenbeek, V., van Deurzen, J., POOLMAN, J. T., & Tommassen, J. (1994) · Microbial Pathogenesis · doi:10.1006/mpat.1994.1085 · Cited by 51
Retzer, M. D., Yu, R., & Schryvers, A. B. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01331.x · Cited by 50
Self-citationA Neisseria meningitidis fbpABC Mutant Is Incapable of Using Nonheme Iron for Growth
Khun, H. H., Kirby, S. D., & Lee, B. C. (1998) · Infection and Immunity · doi:10.1128/iai.66.5.2330-2336.1998 · Cited by 50
Bonnah, R. A., & Schryvers, A. B. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.12.3080-3090.1998 · Cited by 50
Self-citationBaker, E. N., Anderson, B. F., Baker, H. M., MacGillivray, R. T. A., Moore, S. A., Peterson, N. A., Shewry, S. C., & Tweedie, J. W. (1998) · PubMed · Cited by 46
Advances in lactoferrin research
PIERCE, A., & Legrand, D. (2008) · Biochimie · doi:10.1016/j.biochi.2008.10.002 · Cited by 44
Advances in Lactoferrin Research
Spik, G., Legrand, D., Mazurier, J., Pierce, A., & Perraudin, J.-P. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-9068-9 · Cited by 33
Binding and accumulation of hemin in Neisseria gonorrhoeae
Desai, P. J., Nzeribe, R., & Genco, C. A. (1995) · Infection and Immunity · doi:10.1128/iai.63.12.4634-4641.1995 · Cited by 32
Turner, P. C., Thomas, C. E., Elkins, C. A., Clary, S., & Sparling, P. F. (1998) · Infection and Immunity · doi:10.1128/iai.66.11.5215-5223.1998 · Cited by 31
Structural Characterization of the Lactoferrin Receptor from Neisseria meningitidis
Prinz, T., Meyer, M., Pettersson, A. M., & Tommassen, J. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.14.4417-4419.1999 · Cited by 30
Gómez, J. A., Criado, M. T., & Ferreirós, C. M. (1998) · Research in Microbiology · doi:10.1016/s0923-2508(98)80320-3 · Cited by 28
Research works printed but not linked: 2
- Lissolo L. Dumas P. Maitre G. Quentin‐Millet M.J.(1994) Preliminary biochemical characterization of transferrin binding proteins fromNeisseria meningitidis. InPathobiology and Immunobiology of Neisseriaceae. Conde‐Glez C.J. Morse S. Rice P. Sparling F. and Calderon E. (eds). Mexico: Publications Office INSP pp.399–405.
- Sassa S.&Kappas A.(1995) Disorders of heme production and catabolism. InBlood Principles and Practice of Hematology. Handlin R.I. Lux S.E. and Stossel T.P. (eds). Philadelphia: J.B. Lippincott pp.1473.
Cited by
Sorted by citations
Iron Metabolism in Pathogenic Bacteria
Ratledge, C., & Dover, L. G. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.881 · Cited by 1,539
Complete Genome Sequence of Neisseria meningitidis Serogroup B Strain MC58
Tettelin, H., Saunders, N. J. S. G., Heidelberg, J. F., Jeffries, A. C., Nelson, K. E., Eisen, J. A., Ketchum, K. A., Hood, D. W., Peden, J. F., Dodson, R. J., et al. (2000) · Science · doi:10.1126/science.287.5459.1809 · Cited by 1,084
Coordination Chemistry of Bacterial Metal Transport and Sensing
Ma, Z., Jacobsen, F. E., & Giedroc, D. P. (2009) · Chemical Reviews · doi:10.1021/cr900077w · Cited by 643
Structural biology of bacterial iron uptake
Krewulak, K. D., & Vogel, H. J. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.07.026 · Cited by 512
Kell, D. B., Heyden, E. L., & Pretorius, E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01221 · Cited by 460
Metadata
- Authors
- Schryvers, A. B., & Stojiljkovic, I.
- Affiliations
- University of Calgary (CA)
- Corresponding author
- Schryvers, Anthony B.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 1999-06
- Volume
- 32
- Issue
- 6
- Pages
- 1117-1123
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2035814555
- Cited by
- 240
- References
- 36
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 1 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 6 · 2016: 4 · 2015: 6 · 2014: 7 · 2013: 10 · 2012: 8
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- iron acquisition, Neisseria, siderophores, transferrin receptor, lactoferrin, hemoglobin, TonB-dependent receptors, outer membrane transport, vaccine targets, bacterial virulence
- MeSH terms
- Humans, Iron, Neisseria
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
