Cited by 240Bacterial Infections and VaccinesBacterial Genetics and BiotechnologyIron Metabolism and Disorders

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Iron acquisition systems in the pathogenic Neisseria

Schryvers, Anthony B., Stojiljkovic, Igor·1999·Molecular Microbiology

DOI 10.1046/j.1365-2958.1999.01411.x

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Abstract

Pathogenic neisseriae have a repertoire of high‐affinity iron uptake systems to facilitate acquisition of this essential element in the human host. They possess surface receptor proteins that directly bind the extracellular host iron‐binding proteins transferrin and lactoferrin. Alternatively, they have siderophore receptors capable of scavenging iron when exogenous siderophores are present. Released intracellular haem iron present in the form of haemoglobin, haemoglobin–haptoglobin or free haem can be used directly as a source of iron for growth through direct binding by specific surface receptors. Although these receptors may vary in complexity and composition, the key protein involved in the transport of iron (as iron, haem or iron‐siderophore) across the outer membrane is a TonB‐dependent receptor with an overall structure presumably similar to that determined recently for Escherichia coli FhuA or FepA. The receptors are potentially ideal vaccine targets in view of their critical role in survival in the host. Preliminary pilot studies indicate that transferrin receptor‐based vaccines may be protective in humans.

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Authors: Schryvers, A. B., & Stojiljkovic, I.
Affiliations: University of Calgary (CA)
Corresponding author: Schryvers, Anthony B.
ORCID: Schryvers, Anthony B.
Venue: Molecular Microbiology
Publisher: Wiley
Published: 1999-06
Volume: 32
Issue: 6
Pages: 1117-1123
ISSN: 0950-382X (ISSN-L)
1365-2958
DOI: 10.1046/j.1365-2958.1999.01411.x
OpenAlex: W2035814555
Cited by: 240
References: 36
Citations by year: 2025: 1 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 1 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 6 · 2016: 4 · 2015: 6 · 2014: 7 · 2013: 10 · 2012: 8
FWCI: 2.44
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1004 d)
Locations: Molecular Microbiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords: iron acquisition, Neisseria, siderophores, transferrin receptor, lactoferrin, hemoglobin, TonB-dependent receptors, outer membrane transport, vaccine targets, bacterial virulence
MeSH terms: Humans, Iron, Neisseria

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Iron acquisition systems in the pathogenic Neisseria

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