The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Inducible prophages contribute to Salmonella virulence in mice
Open accessAbstract
We show that Salmonella typhimurium harbours two fully functional prophages, Gifsy‐1 and Gifsy‐2, that can be induced by standard treatments or, more effectively, by exposing bacteria to hydrogen peroxide. Curing bacteria for the Gifsy‐2 prophage significantly reduces Salmonella's ability to establish a systemic infection in mice. Cured strains recover their virulence properties upon relysogenization. Phage Gifsy‐2 carries the sodC gene for a periplasmic [Cu,Zn]‐superoxide dismutase previously implicated in the bacterial defences against killing by macrophages. The contribution of the Gifsy‐1 prophage to virulence — undetectable in the presence of Gifsy‐2 as prophage — becomes significant in cells that lack Gifsy‐2 but carry the sodC gene integrated in the chromosome. This confirms the involvement of Gifsy‐2‐encoded SodC protein in Salmonella pathogenicity and suggests that the Gifsy‐1 prophage carries one or more additional virulence genes that have a functional equivalent on the Gifsy‐2 genome.
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Cited by
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Transfer of photosynthesis genes to and from Prochlorococcus viruses
Lindell, D., Sullivan, M. B., Johnson, Z. I., Tolonen, A. C., Rohwer, F., & Chisholm, S. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401526101 · Cited by 516
Epitope tagging of chromosomal genes in Salmonella
Uzzau, S., Figueroa-Bossi, N., Rubino, S., & Bossi, L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261348198 · Cited by 511
Self-citationAlternatives to antibiotics: bacteriocins, antimicrobial peptides and bacteriophages
Joerger, R. (2003) · Poultry Science · doi:10.1093/ps/82.4.640 · Cited by 465
Functions and effectors of the Salmonella pathogenicity island 2 type III secretion system
Waterman, S. R., & Holden, D. W. (2003) · Cellular Microbiology · doi:10.1046/j.1462-5822.2003.00294.x · Cited by 400
Metadata
- Authors
- Figueroa‐Bossi, N., & Bossi, L.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 1999-07
- Volume
- 33
- Issue
- 1
- Pages
- 167-176
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2013735086
- Cited by
- 273
- References
- 30
- FWCI
- 17.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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