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Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent.
Open accessAbstract
Salmonella typhimurium is a facultative intracellular pathogen capable of surviving within phagocytic cells of the reticuloendothelial system. To identify the genes important for intracellular survival, 9516 independent Tn10 insertional mutations were isolated in a virulent strain of S. typhimurium. By using an in vitro assay for survival within macrophages, 83 Tn10 mutants have been identified that have a diminished capacity for intracellular survival (designated MS or macrophage survival mutants). All of the MS mutants are less virulent than the parent strain in vivo, demonstrating that, for Salmonella, survival within the macrophage is essential for virulence. Thirty-seven of the MS mutants have been characterized as to their phenotype, including several mutations that confer sensitivity to specific microbiocidal mechanisms of the macrophage.
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Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels
Beauchamp, C., & Fridovich, I. (1971) · Analytical Biochemistry · doi:10.1016/0003-2697(71)90370-8 · Cited by 12,892
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Groisman, E. A. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.6.1835-1842.2001 · Cited by 887
Eriksson, S., Lucchini, S., Thompson, A., Rhen, M., & Hinton, J. C. D. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03313.x · Cited by 846
The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1
Hersh, D., Monack, D. M., Smith, M. R., Ghori, N., Falkow, S., & Zychlinsky, A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2396 · Cited by 788
Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes
Vazquez-Torres, A., Jones-Carson, J., Bäumler, A. J., Falkow, S., Valdivia, R., Brown, W., Le, M., Berggren, R., Parks, W. T., & Fang, F. C. (1999) · Nature · doi:10.1038/44593 · Cited by 683
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Coburn, B., Grassl, G. A., & Finlay, B. B. (2007) · Immunology & Cell Biology · doi:10.1038/sj.icb.7100007 · Cited by 690
Metadata
- Authors
- Fields, P. I., Swanson, R. V., Haidaris, C. G., & Heffron, F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1986-07
- Volume
- 83
- Issue
- 14
- Pages
- 5189-5193
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1992144107
- Cited by
- 1,114
- References
- 1
- FWCI
- 42.60
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent. https://app.cochat.ai/papers/10.1073/pnas.83.14.5189
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- Fields, P. I., Swanson, R. V., Haidaris, C. G., & Heffron, F. (1986). Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.83.14.5189
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
