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Cited by 335Tuberculosis Research and EpidemiologyMycobacterium research and diagnosisInfectious Diseases and Tuberculosis

The DOI matches its Crossref record.

Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice

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Dubnau, Eugenie, Chan, John, Raynaud, Catherine, Mohan, Vellore P., Lanéelle, Marie‐Antoinette, Yu, Keming, Quémard, Annaik, Smith, Issar, Daffé, Mamadou·2000·Molecular Microbiology
DOI 10.1046/j.1365-2958.2000.01882.x
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Abstract

Members of the Mycobacterium tuberculosis group synthesize a family of long‐chain fatty acids, mycolic acids, which are located in the cell envelope. These include the non‐oxygenated α‐mycolic acid and the oxygenated keto‐ and methoxymycolic acids. The function in bacterial virulence, if any, of these various types of mycolic acids is unknown. We have constructed a mutant strain of M. tuberculosis with an inactivated hma (cmaA, mma4) gene; this mutant strain no longer synthesizes oxygenated mycolic acids, has profound alterations in its envelope permeability and is attenuated in mice.

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Crossref · 10.1046/j.1365-2958.2000.01882.x

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  • The methoxy mycolic acid synthase MmaA4 is more important in the chronic phase than the active phase of mouse infections, supporting the idea that oxygenated modifications predominate in stasis.

    “The methoxy mycolic acid synthase MmaA4 is more important in the chronic phase than the active phase of mouse infections48,98, supporting the idea that oxygenated modifications predominate in stasis.”

    From The mycobacterial cell envelope — a moving target (2020) · cites this paper as [98]

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Metadata

Authors
Dubnau, E., Chan, J., Raynaud, C., Mohan, V. P., Lanéelle, M., Yu, K., Quémard, A., Smith, I., & Daffé, M.
Affiliations
  • Albert Einstein College of Medicine (US)
  • Centre National de la Recherche Scientifique (FR)
Corresponding author
Dubnau, Eugenie
ORCID
Chan, John
Venue
Molecular Microbiology
Publisher
Wiley
Published
2000-05
Volume
36
Issue
3
Pages
630-637
ISSN
  • 0950-382X (ISSN-L)
  • 1365-2958
DOI
10.1046/j.1365-2958.2000.01882.x
OpenAlex
W1552418306
Cited by
335
References
0
Citations by year
2026: 5 · 2025: 10 · 2024: 7 · 2023: 7 · 2022: 8 · 2021: 14 · 2020: 15 · 2019: 17 · 2018: 17 · 2017: 12 · 2016: 13 · 2015: 15 · 2014: 16 · 2013: 19 · 2012: 12
FWCI
8.64
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 627 d)
Locations
  • Molecular Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation
  • Centre National de la Recherche Scientifique
  • National Institutes of Health
  • National Institute of Allergy and Infectious Diseases (AI-44856)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
  • Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
  • Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
Keywords
Mycobacterium tuberculosis, mycolic acids, bacterial virulence, cell envelope permeability, mouse infection, long-chain fatty acids
MeSH terms
Animals, Cell Line, Cell Membrane Permeability, Chenodeoxycholic Acid, Female, Genes, Bacterial, Glycerol, Humans, Hydrogen Peroxide, Mice, Inbred C57BL, Monocytes, Mycobacterium tuberculosis, Mycolic Acids, Oxidation-Reduction, Tuberculosis, Virulence, Mutagenesis, Mice

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