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A protein with similarity to the human retinoblastoma binding protein 2 acts specifically as a repressor for genes regulated by the b mating type locus in Ustilago maydis
Open accessAbstract
Pathogenic development in the corn smut fungus Ustilago maydis is controlled by a heterodimer of the two homeodomain proteins bE and bW which are encoded by the b mating type locus. The bE/bW heterodimer is thought to achieve its function as a transcriptional regulator of pathogenicity genes, either directly by binding to cis regulatory sequences or indirectly via a b‐dependent regulatory cascade. In a screen for components of the b‐dependent regulatory cascade we have isolated Rum1 (r egulator U. m aydis 1), a protein with similarities to the human retinoblastoma binding protein 2. Deletion of rum1 results in expression of several b regulated genes independently from their activation via the bE/bW heterodimer. rum1 mutant strains remain pathogenic, proliferate in planta, but fail to produce spores. The defect leads to an arrest in spore development at a defined stage before the spore wall is generated. Deduced from the highly conserved domain structure of Rum1 that includes a DNA‐binding motif and a region known to facilitate the interaction with histone deacetylases, we propose that Rum1 functions as a transcriptional repressor through the modulation of chromatin structure.
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The Ustilago maydis RUM1 homolog regulates transcription of the bE and bW homeodomain proteins, as well as of genes regulated by the bE/bW homeodomain complex.
“Intriguingly, the Ustilago maydis RUM1 homolog regulates transcription of the bE and bW homeodomain proteins, as well as of genes regulated by the bE/bW homeodomain complex [29].”
From Light Controls Growth and Development via a Conserved Pathway in the Fungal Kingdom (2005) · cites this paper as [29]
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Cited by
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Light Controls Growth and Development via a Conserved Pathway in the Fungal Kingdom
Idnurm, A., & Heitman, J. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030095 · Cited by 306
“Intriguingly, the Ustilago maydis RUM1 homolog regulates transcription of the bE and bW homeodomain proteins, as well as of genes regulated by the bE/bW homeodomain complex [29].”
Background
Metadata
- Authors
- Quadbeck‐Seeger, C., Wanner, G., Huber, S., Kahmann, R., & Kämper, J.
- Affiliations
- Ludwig-Maximilians-Universität München (DE)
- Corresponding author
- Kämper, Jörg
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2000-10
- Volume
- 38
- Issue
- 1
- Pages
- 154-166
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2089774992
- Cited by
- 66
- References
- 72
- Citations by year
- 2023: 1 · 2022: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SFB 190)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Pathogens and Fungal Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- Ustilago maydis, transcriptional repressor, sporulation, virulence genes, homeodomain transcription factor, chromatin structure, spore wall formation
- MeSH terms
- Mating Factor, Amino Acid Sequence, Base Sequence, Fungal Proteins, Humans, Molecular Sequence Data, Peptides, Phenotype, Repressor Proteins, Ustilago, Gene Expression Regulation, Fungal, Sequence Homology, Amino Acid, DNA Primers, Schizosaccharomyces pombe Proteins
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