Cited by 218Fungal and yeast genetics researchAntifungal resistance and susceptibilityFungal Infections and Studies

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Candida albicans Als1p: an adhesin that is a downstream effector of the EFG1 filamentation pathway

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Fu, Yue, Ibrahim, Ashraf S., Sheppard, Donald C., Chen, Yee‐Chun, French, Samuel W., Cutler, Jim E., Filler, Scott G., Edwards, John E.·2002·Molecular Microbiology

DOI 10.1046/j.1365-2958.2002.02873.x

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Abstract

Summary: Filamentation and adherence to host cells are critical virulence factors of Candida albicans. Multiple filamentation regulatory pathways have been discovered in C. albicans using Saccharomyces cerevisiae as a model. In S. cerevisiae, these pathways converge on Flo11p, which functions as a downstream effector of filamentation and also mediates cell–cell adherence (flocculation). In C. albicans, such effector(s) have not yet been identified. Here, we demonstrate that the cell surface protein Als1p is an effector of filamentation in C. albicans. We show that Als1p expression is controlled by the transcription factor Efg1p, which is known to be a key regulator of filamentation in C. albicans. Further, disruption of ALS1 inhibited filamentation, and autonomous expression of Als1p restored filamentation in an efg1 homozygous null mutant. Thus, Als1p functions as a downstream effector of the EFG1 filamentation pathway. In addition, we found that Als1p mediates both flocculation and adherence of C. albicans to endothelial cells in vitro. As a cell surface glycoprotein that mediates filamentation and adherence, Als1p has both structural and functional similarity to S. cerevisiae Flo11p. Consistent with our in vitro results, Als1p was required for both normal filamentation and virulence in the mouse model of haematogenously disseminated candidiasis.

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Authors: Fu, Y., Ibrahim, A. S., Sheppard, D. C., Chen, Y., French, S. W., Cutler, J. E., Filler, S. G., & Edwards, J. E.
Affiliations: University of California, Los Angeles (US)
Montana State University (US)
Corresponding author: Fu, Yue
ORCID: Fu, Yue
Ibrahim, Ashraf S.
Sheppard, Donald C.
Chen, Yee‐Chun
French, Samuel W.
Filler, Scott G.
Edwards, John E.
Venue: Molecular Microbiology
Publisher: Wiley
Published: 2002-04
Volume: 44
Issue: 1
Pages: 61-72
ISSN: 0950-382X (ISSN-L)
1365-2958
DOI: 10.1046/j.1365-2958.2002.02873.x
OpenAlex: W2138126650
Cited by: 218
References: 31
Citations by year: 2026: 3 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 5 · 2015: 10 · 2014: 17 · 2013: 12 · 2012: 11
FWCI: 5.58
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 19 d)
Locations: Molecular Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
Bristol-Myers Squibb
Toyota USA
National Institutes of Health (1s10rr013004-01a1)
National Institute of Allergy and Infectious Diseases (P01 AI-37194, R29AI040636, R01AI019990, R01-AI19990, P01AI037194, R29 AI 40636)
National Center for Research Resources (1S10 RR 13004, M01RR000425, M01-RR00425)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
Keywords: Candida albicans, filamentation, cell adhesion, flocculation, cell surface glycoproteins, virulence, transcriptional regulation
MeSH terms: Candida albicans, Cell Adhesion, DNA-Binding Proteins, Endothelium, Vascular, Fungal Proteins, Humans, Saccharomyces cerevisiae, Species Specificity, Transcription Factors, Restriction Mapping, Gene Expression Regulation, Fungal, Polymerase Chain Reaction, DNA Primers

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Candida albicans Als1p: an adhesin that is a downstream effector of the EFG1 filamentation pathway

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