The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Candida albicans Als1p: an adhesin that is a downstream effector of the EFG1 filamentation pathway
Open accessAbstract
Summary: Filamentation and adherence to host cells are critical virulence factors of Candida albicans. Multiple filamentation regulatory pathways have been discovered in C. albicans using Saccharomyces cerevisiae as a model. In S. cerevisiae, these pathways converge on Flo11p, which functions as a downstream effector of filamentation and also mediates cell–cell adherence (flocculation). In C. albicans, such effector(s) have not yet been identified. Here, we demonstrate that the cell surface protein Als1p is an effector of filamentation in C. albicans. We show that Als1p expression is controlled by the transcription factor Efg1p, which is known to be a key regulator of filamentation in C. albicans. Further, disruption of ALS1 inhibited filamentation, and autonomous expression of Als1p restored filamentation in an efg1 homozygous null mutant. Thus, Als1p functions as a downstream effector of the EFG1 filamentation pathway. In addition, we found that Als1p mediates both flocculation and adherence of C. albicans to endothelial cells in vitro. As a cell surface glycoprotein that mediates filamentation and adherence, Als1p has both structural and functional similarity to S. cerevisiae Flo11p. Consistent with our in vitro results, Als1p was required for both normal filamentation and virulence in the mouse model of haematogenously disseminated candidiasis.
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In the citing paper
“even though previous studies have clearly demonstrated that Als1 is an adhesin [36,37].”
From Als3 Is a Candida albicans Invasin That Binds to Cadherins and Induces Endocytosis by Host Cells (2007) · cites this paper as [36]
In the citing paper
“Binding of rAls1-N to the beads was verified by indirect immunofluorescence with a monoclonal antibody directed against rAls1-N [36].”
From Als3 Is a Candida albicans Invasin That Binds to Cadherins and Induces Endocytosis by Host Cells (2007) · cites this paper as [36]
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Cites
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Candida Infections of the Genitourinary Tract
Achkar, J. M., & Fries, B. C. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00076-09 · Cited by 736
Als3 Is a Candida albicans Invasin That Binds to Cadherins and Induces Endocytosis by Host Cells
Phan, Q. T., Myers, C. L., Fu, Y., Sheppard, D. C., Yeaman, M. R., Welch, W. H., Ibrahim, A. S., Edwards, J. E., & Filler, S. G. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050064 · Cited by 641
Self-citationRegulatory circuitry governing fungal development, drug resistance, and disease.
Shapiro, R. S., Robbins, N., & Cowen, L. E. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00045-10 · Cited by 576
A Pseudomonas aeruginosa quorum‐sensing molecule influences Candida albicans morphology
Hogan, D. A., Vik, Å., & Kolter, R. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04349.x · Cited by 575
Biswas, S., Dijck, P. V., & Datta, A. (2007) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00009-06 · Cited by 539
Metadata
- Authors
- Fu, Y., Ibrahim, A. S., Sheppard, D. C., Chen, Y., French, S. W., Cutler, J. E., Filler, S. G., & Edwards, J. E.
- Affiliations
- University of California, Los Angeles (US)
- Montana State University (US)
- Corresponding author
- Fu, Yue
- ORCID
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2002-04
- Volume
- 44
- Issue
- 1
- Pages
- 61-72
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2138126650
- Cited by
- 218
- References
- 31
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 5 · 2015: 10 · 2014: 17 · 2013: 12 · 2012: 11
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- Bristol-Myers Squibb
- Toyota USA
- National Institutes of Health (1s10rr013004-01a1)
- National Institute of Allergy and Infectious Diseases (P01 AI-37194, R29AI040636, R01AI019990, R01-AI19990, P01AI037194, R29 AI 40636)
- National Center for Research Resources (1S10 RR 13004, M01RR000425, M01-RR00425)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Keywords
- Candida albicans, filamentation, cell adhesion, flocculation, cell surface glycoproteins, virulence, transcriptional regulation
- MeSH terms
- Candida albicans, Cell Adhesion, DNA-Binding Proteins, Endothelium, Vascular, Fungal Proteins, Humans, Saccharomyces cerevisiae, Species Specificity, Transcription Factors, Restriction Mapping, Gene Expression Regulation, Fungal, Polymerase Chain Reaction, DNA Primers
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