The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Multiple mechanisms for the activation of human platelet aggregation by Staphylococcus aureus: roles for the clumping factors ClfA and ClfB, the serine–aspartate repeat protein SdrE and protein A
Open accessAbstract
Summary: The ability of Staphylococcus aureus cells to induce platelet aggregation has long been recognized. However, despite several attempts to identify the mechanisms involved in this interaction, the nature of the bacterial receptors required remains poorly understood. Using genetic manipulation, this study for the first time provides clear evidence that several S. aureus surface proteins participate in the inter‐action with platelets. Mutants of S. aureus strain Newman lacking one or more surface proteins were tested for their ability to stimulate platelet aggre‐gation. This approach was complemented by the expression of a number of candidate proteins in the non‐aggregating Gram‐positive bacterium Lacto‐coccus lactis. S. aureus‐induced aggregation was monophasic and was dependent on the platelet receptor GPIIb/IIIa. The fibrinogen‐binding proteins, clumping factors A and B and the serine‐aspartate repeat protein SdrE could each induce aggregation when expressed in L. lactis. Although protein A expressed in L. lactis was not capable of inducing aggregation independently, it enhanced the aggregation response when expressed on the surface of S. aureus. Thus, S. aureus has multiple mechanisms for stimulating platelet aggregation. Such functional redundancy suggests that this phenomenon may be important in the pathogenesis of invasive diseases such as infective endocarditis.
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
λ ZAP: a bacteriophage λ expression vector with in vivo excision properties
Short, J. M., Fernandez, J. M., Sorge, J. A., & Huse, W. D. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.15.7583 · Cited by 1,365
Gasson, M. J. (1983) · Journal of Bacteriology · doi:10.1128/jb.154.1.1-9.1983 · Cited by 1,322
MSCRAMM-MEDIATED ADHERENCE OF MICROORGANISMS TO HOST TISSUES
Patti, J. M., Allen, B. L., McGavin, M. J., & Höök, M. (1994) · Annual Review of Microbiology · doi:10.1146/annurev.mi.48.100194.003101 · Cited by 1,191
Molecular characterization of the clumping factor (fibrinogen receptor) of Staphylococcus aureus
McDevitt, D., Francois, P., Vaudaux, P., & Foster, T. J. (1994) · Molecular Microbiology · doi:10.1111/j.1365-2958.1994.tb00304.x · Cited by 546
Self-citationWilson, W. R. (1995) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1995.03530210060032 · Cited by 492
Efficient insertional mutagenesis in lactococci and other gram-positive bacteria
Maguin, E., Prévost, H., Ehrlich, S. D., & Gruss, A. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.3.931-935.1996 · Cited by 486
Clumping factor B (ClfB), a new surface‐located fibrinogen‐binding adhesin of Staphylococcus aureus
Ní Eidhin, D., Perkins, S., Francois, P., Vaudaux, P., Höök, M., & Foster, T. J. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.01050.x · Cited by 418
Self-citationStaphylococcal protein A consists of five IgG-binding domains
MOKS, T., ABRAHMSEN, L., NILSSON, B., HELLMAN, U., SJOQUIST, J., & UHLEN, M. (1986) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1986.tb09625.x · Cited by 371
Greene, C., McDevitt, D., Francois, P., Vaudaux, P. E., Lew, D. P., & Poster, T. J. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.mmi_17061143.x · Cited by 305
Cited by
Tong, S. Y. C., Davis, J. S., Eichenberger, E., Holland, T. L., & Fowler, V. G. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00134-14 · Cited by 5,192
Staphylococcus aureus Panton-Valentine Leukocidin Causes Necrotizing Pneumonia
Labandeira-Rey, M., Couzon, F., Boisset, S., Brown, E. L., Bes, M., Benito, Y., Barbu, E. M., Vazquez, V., Höök, M., Etienne, J., et al. (2007) · Science · doi:10.1126/science.1137165 · Cited by 709
The interaction of bacterial pathogens with platelets
Fitzgerald, J. R., Foster, T. J., & Cox, D. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1425 · Cited by 489
Self-citationSurface Adhesins of Staphylococcus aureus
Clarke, S. R., & Foster, S. J. (2006) · Advances in Microbial Physiology · doi:10.1016/s0065-2911(06)51004-5 · Cited by 275
Corrigan, R. M., Miajlovic, H., & Foster, T. J. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-22 · Cited by 226
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Metadata
- Authors
- O´Brien, L., Kerrigan, S. W., Kaw, G., Hogan, M., Penadés, J., Litt, D., Fitzgerald, D. J., Foster, T. J., & Cox, D.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2002-05
- Volume
- 44
- Issue
- 4
- Pages
- 1033-1044
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2119370402
- Cited by
- 309
- References
- 39
- FWCI
- 8.28
- Type
- journal article
- Language
- en
- Open access
- bronze
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- O´Brien, L., Kerrigan, S. W., Kaw, G., Hogan, M., Penadés, J., Litt, D., Fitzgerald, D. J., Foster, T. J., & Cox, D. (2002). Multiple mechanisms for the activation of human platelet aggregation by Staphylococcus aureus: roles for the clumping factors ClfA and ClfB, the serine–aspartate repeat protein SdrE and protein A. Molecular Microbiology. https://doi.org/10.1046/j.1365-2958.2002.02935.x
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