The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Staphylococcus aureus Panton-Valentine Leukocidin Causes Necrotizing Pneumonia
Abstract
The Staphylococcus aureus Panton-Valentine leukocidin (PVL) is a pore-forming toxin secreted by strains epidemiologically associated with the current outbreak of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and with the often-lethal necrotizing pneumonia. To investigate the role of PVL in pulmonary disease, we tested the pathogenicity of clinical isolates, isogenic PVL-negative and PVL-positive S. aureus strains, as well as purified PVL, in a mouse acute pneumonia model. Here we show that PVL is sufficient to cause pneumonia and that the expression of this leukotoxin induces global changes in transcriptional levels of genes encoding secreted and cell wall–anchored staphylococcal proteins, including the lung inflammatory factor staphylococcal protein A (Spa).
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Cites
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Self-citationImmune evasion by staphylococci
Foster, T. J. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1289 · Cited by 1,222
Surface protein adhesins of Staphylococcus aureus
Foster, T. J., & Höök, M. (1998) · Trends in Microbiology · doi:10.1016/s0966-842x(98)01400-0 · Cited by 986
Horsburgh, M. J., Aish, J. L., White, I. J., Shaw, L., Lithgow, J. K., & Foster, S. J. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.19.5457-5467.2002 · Cited by 699
Community-Associated MRSA — Resistance and Virulence Converge
Chambers, H. F. (2005) · New England Journal of Medicine · doi:10.1056/nejme058023 · Cited by 423
Genestier, A.-L., Michallet, M.-C., Prévost, G., Bellot, G., Chalabreysse, L., Peyrol, S., Thivolet, F., Etienne, J., Lina, G., Vallette, F. M., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22684 · Cited by 416
Self-citationStaphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1
Gómez, M. I., Lee, A., Reddy, B., Muir, A., Soong, G., Pitt, A., Cheung, A., & Prince, A. (2004) · Nature Medicine · doi:10.1038/nm1079 · Cited by 412
Staphylococcus aureus RNAIII and the endoribonuclease III coordinately regulate spa gene expression
Huntzinger, E., Boisset, S., Saveanu, C., Benito, Y., Geissmann, T., Namane, A., Lina, G., Etienne, J., Ehresmann, B., Ehresmann, C., et al. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600572 · Cited by 361
Self-citationKullik, I., Giachino, P., & Fuchs, T. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.18.4814-4820.1998 · Cited by 324
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Research works printed but not linked: 3
- P. N. Panton, M. C. Camb, F. C. O. Valentine, M. R. C. P. Lond, Lancet1, 506 (1932).
- P. Thomas, M. Riffelmann, B. Schweiger, S. Dominik, C. H. von Konig, Pediatr. Infect. Dis. J.22, 201 (2003).
- We thank S. L. Mueller-Ortiz and S. M. Drouin for their invaluable help establishing the animal model; Z. Chroneos for his input in the interpretation of histological samples; C. Badiou for technical assistance; G. Lina for scientific advice; and S. Foster T. Foster B. Fournier R. Novick and P. McNamara for providing strains. This work was supported by grants from the TAMUS HSC to M.G.B. from the French Ministry of Research to F.V. and NIH AI020624 to M.H. Support from the Neva and Wesley West and the Hamill Foundations were awarded to M.H. The authors declare that they have no competing financial interests. Microarray data are deposited in the GEO database (http://www.ncbi.nlm.nih.gov/projects/geo/) under the accession number GPL4653.
Cited by
Tong, S. Y. C., Davis, J. S., Eichenberger, E., Holland, T. L., & Fowler, V. G. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00134-14 · Cited by 5,192
Waves of resistance: Staphylococcus aureus in the antibiotic era
Chambers, H. F., & DeLeo, F. R. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2200 · Cited by 2,718
David, M. Z., & Daum, R. S. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00081-09 · Cited by 1,972
Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology
Lakhundi, S., & Zhang, K. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00020-18 · Cited by 1,637
Pilsczek, F. H., Salina, D., Poon, K. K. H., Fahey, C., Yipp, B. G., Sibley, C. D., Robbins, S. M., Green, F. H. Y., Surette, M. G., Sugai, M., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000675 · Cited by 1,114
Self-citation
Metadata
- Authors
- Labandeira-Rey, M., Couzon, F., Boisset, S., Brown, E. L., Bes, M., Benito, Y., Barbu, E. M., Vazquez, V., Höök, M., Etienne, J., Vandenesch, F., & Bowden, M. G.
- Venue
- Science
- Published
- 2007-02-23
- Volume
- 315
- Issue
- 5815
- Pages
- 1130-1133
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2126812384
- Cited by
- 709
- References
- 19
- FWCI
- 63.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- Labandeira-Rey, M., Couzon, F., Boisset, S., Brown, E. L., Bes, M., Benito, Y., Barbu, E. M., Vazquez, V., Höök, M., Etienne, J., Vandenesch, F., & Bowden, M. G. (2007). Staphylococcus aureus Panton-Valentine Leukocidin Causes Necrotizing Pneumonia. Science. https://doi.org/10.1126/science.1137165
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
