The DOI matches its Crossref record.
Two‐component system VraSR positively modulates the regulation of cell‐wall biosynthesis pathway in Staphylococcus aureus
Abstract
Summary: DNA microarray covering the whole genome of Staphylococcus aureus strain N315 was prepared to investigate transcription profiles. The microarray analyses revealed that vancomycin induces transcription of 139 genes. Forty‐six genes among them failed to be induced in the vraSR null mutant KVR. Part of the genes regulated by VraSR system is associated with cell‐wall biosynthesis, such as PBP2, SgtB and MurZ. Other cell‐wall synthesis inhibitors also induced VraSR, suggesting that the sensor kinase VraS responds to the damage of cell‐wall structure or inhibition of cell‐wall biosynthesis. Additionally, the vraSR null mutants derived from hetero‐ and homo‐methicillin‐resistant S. aureus showed significant decrease of resistance against teicoplanin, β‐lactam, bacitracin and fosfomycin but not of d‐cycloserine and levofloxacin. The observation strongly indicates that VraSR constitutes a positive regulator of cell‐wall peptidoglycan synthesis, and that is deeply involved in the expression of β‐lactam and glycopeptide resistance in S. aureus.
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Cited by
Howden, B. P., Davies, J. K., Johnson, P. D. R., Stinear, T. P., & Grayson, M. L. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00042-09 · Cited by 962
Stimulus Perception in Bacterial Signal-Transducing Histidine Kinases
Mascher, T., Helmann, J. D., & Unden, G. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00020-06 · Cited by 721
Mechanisms of vancomycin resistance in Staphylococcus aureus
Gardete, S., & Tomasz, A. (2014) · Journal of Clinical Investigation · doi:10.1172/jci68834 · Cited by 565
Insights into Mechanisms Used by Staphylococcus aureus to Avoid Destruction by Human Neutrophils
Voyich, J. M., Braughton, K. R., Sturdevant, D. E., Whitney, A. R., Saïd-Salim, B., Porcella, S. F., Long, R. D., Dorward, D. W., Gardner, D. J., Kreiswirth, B. N., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.6.3907 · Cited by 563
Mwangi, M. M., Wu, S. W., Zhou, Y., Sieradzki, K., de Lencastre, H., Richardson, P., Bruce, D., Rubin, E., Myers, E., Siggia, E. D., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609839104 · Cited by 538
Metadata
- Authors
- Kuroda, M., Kuroda, H., Oshima, T., Takeuchi, F., Mori, H., & Hiramatsu, K.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2003-08
- Volume
- 49
- Issue
- 3
- Pages
- 807-821
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2151693231
- Cited by
- 512
- References
- 0
- FWCI
- 9.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kuroda, M., Kuroda, H., Oshima, T., Takeuchi, F., Mori, H., & Hiramatsu, K. (2003). Two‐component system VraSR positively modulates the regulation of cell‐wall biosynthesis pathway in Staphylococcus aureus. Molecular Microbiology. https://doi.org/10.1046/j.1365-2958.2003.03599.x
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