The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Evidence for the importance of genetic structuring to the structural and functional specialization of the Plasmodium falciparum var gene family
Open accessAbstract
Summary: The var gene family encodes Plasmodium falciparum erythrocyte membrane 1 (PfEMP1) proteins that act as virulence factors responsible for both antigenic variation and cytoadherence of infected erythrocytes. These proteins orchestrate infected erythrocyte sequestration from blood circulation and contribute to adhesion‐based complications of P. falciparum malaria infections. For this study, we analysed the genetic organization and strain structure of var genes and present evidence for three separately evolving groups that have, in part, functionally diverged and differ between subtelomeric and central chromosomal locations. Our analyses suggest that a recombination hierarchy limits reassortment between groups and may explain why some var genes are unusually conserved between parasite strains. This recombination hierarchy, coupled with binding and immune selection, shapes the variant antigen repertoire and has structural, functional and evolutionary consequences for the PfEMP1 protein family that are directly relevant to malaria pathogenesis.
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Adherence of Plasmodium falciparum to Chondroitin Sulfate A in the Human Placenta
Fried, M., & Duffy, P. E. (1996) · Science · doi:10.1126/science.272.5267.1502 · Cited by 1,108
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Self-citationNielsen, M. A., Staalsoe, T., Kurtzhals, J. A. L., Goka, B. Q., Dodoo, D., Alifrangis, M., Theander, T. G., Akanmori, B. D., & Hviid, L. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3444 · Cited by 207
Two DBLγ subtypes are commonly expressed by placental isolates of Plasmodium falciparum
Fried, M., & Duffy, P. E. (2002) · Molecular and Biochemical Parasitology · doi:10.1016/s0166-6851(02)00103-2 · Cited by 44
Cited by
Malaria in pregnancy: pathogenesis and immunity
Rogerson, S. J., Hviid, L., Duffy, P. E., Leke, R. F., & Taylor, D. W. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70022-1 · Cited by 628
Population Genomics of the Immune Evasion (var) Genes of Plasmodium falciparum
Barry, A. E., Leliwa-Sytek, A., Tavul, L., Imrie, H., Migot-Nabias, F., Brown, S. M., McVean, G. A. V., & Day, K. P. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030034 · Cited by 199
(2015) · Advances in Parasitology · doi:10.1016/bs.apar.2015.02.004 · Cited by 162
Trimnell, A. R., Kraemer, S. M., Mukherjee, S., Phippard, D. J., Janes, J. H., Flamoe, E., Su, X.-Z., Awadalla, P., & Smith, J. D. (2006) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2006.03.012 · Cited by 165
Self-citationGamain, B., Trimnell, A. R., Scheidig, C., Scherf, A., Miller, L. H., & Smith, J. D. (2005) · The Journal of Infectious Diseases · doi:10.1086/428137 · Cited by 145
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Metadata
- Authors
- Kraemer, S. M., & Smith, J. D.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2003-11-11
- Volume
- 50
- Issue
- 5
- Pages
- 1527-1538
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2106544700
- Cited by
- 227
- References
- 5
- FWCI
- 15.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kraemer, S. M., & Smith, J. D. (2003). Evidence for the importance of genetic structuring to the structural and functional specialization of the Plasmodium falciparum var gene family. Molecular Microbiology. https://doi.org/10.1046/j.1365-2958.2003.03814.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
