Global genetic diversity and evolution of var genes associated with placental and severe childhood malaria
Abstract
In Plasmodium falciparum, var genes encode adhesive proteins that are transported to the surface of infected erythrocytes and act as major virulence determinants for infected erythrocyte binding and immune evasion. Var genes are highly diverse and can be classified into five major groups (UpsA, B, C, D, and E). Previous serological studies have suggested that the UpsA var group may contain common antigenic types that have important roles in severe childhood malaria. Here, our analysis found that UpsA vars are highly diverse between 22 world-wide parasite isolates, although they could be grouped into two broad clusters that may be separately recombining. By comparison, orthologs of the UpsA-linked Type 3 var and UpsE-linked var2csa were detected in nearly all parasite isolates, and a var2csa ortholog was also present in a chimpanzee malaria P. reichenowi that diverged from P. falciparum approximately 5-7 million years ago. Although the specific function of Type 3 var genes is unknown, var2csa is a leading candidate for a pregnancy associated malaria vaccine. Compared to typical var genes, var2csa is unusually conserved but still had only 54-94% amino acid identity in extracellular binding regions. However, var2csa alleles have extensive gene mosaicism within polymorphic blocks that are shared between world-wide parasite isolates and recognizable in P. rechenowi suggesting a high rate of self-self recombination and an ancient and globally-related pool of var2csa polymorphism. T…
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VAR2CSA shows substantial sequence and structure conservation between isolates, which could explain the geographical independence of antibody responses to the VSA expressed by iEs from pregnant women.
“VAR2CSA show substantial sequence and structure conservation between isolates (Trimnell et al. , 2006), which could explain the geographical independence of antibody responses to the VSA expressed by iEs from pregnant women.”
From Towards a vaccine against pregnancy-associated malaria (2008) · cites this paper as Trimnell et al., 2006
Analysis of var2csa from field isolates has revealed alternating areas of substantial interclonal polymorphism.
“but analysis of var2csa from field isolates has revealed alternating areas of substantial interclonal polymorphism (Dahlback et al. , 2006; Trimnell et al. , 2006).”
From Towards a vaccine against pregnancy-associated malaria (2008) · cites this paper as Trimnell et al., 2006
Cites
Genome sequence of the human malaria parasite Plasmodium falciparum
Gardner, M. J., Hall, N., Fung, E., White, O., Berriman, M., Hyman, R. W., Carlton, J. M., Pain, A., Nelson, K. E., Bowman, S., et al. (2002) · Nature · doi:10.1038/nature01097 · Cited by 4,407 · see citing works
Antibody neutralization and escape by HIV-1
Wei, X., Decker, J. M., Wang, S., Hui, H., Kappes, J. C., Wu, X., Salazar-Gonzalez, J. F., Salazar, M. G., Kilby, J. M., Saag, M. S., et al. (2003) · Nature · doi:10.1038/nature01470 · Cited by 2,421 · see citing works
A Test of Neutral Molecular Evolution Based on Nucleotide Data
Hudson, R. R., Kreitman, M., & Aguadé, M. (1987) · Genetics · doi:10.1093/genetics/116.1.153 · Cited by 1,788 · see citing works
The pathogenic basis of malaria
Miller, L. H., Baruch, D. I., Marsh, K., & Doumbo, O. K. (2002) · Nature · doi:10.1038/415673a · Cited by 1,754 · see citing works
Su, X.-Z., Heatwole, V. M., Wertheimer, S. P., Guinet, F., Herrfeldt, J. A., Peterson, D. S., Ravetch, J. A., & Wellems, T. E. (1995) · Cell · doi:10.1016/0092-8674(95)90055-1 · Cited by 1,219 · see citing works
Self-citationAdherence of <i>Plasmodium falciparum</i> to Chondroitin Sulfate A in the Human Placenta
Fried, M., & Duffy, P. E. (1996) · Science · doi:10.1126/science.272.5267.1502 · Cited by 1,108 · see citing works
Baruch, D., Pasloske, B., Singh, H. B., Bi, X., Ma, X. C., Feldman, M., Taraschi, T., & Howard, R. J. (1995) · Cell · doi:10.1016/0092-8674(95)90054-3 · Cited by 1,087 · see citing works
Smith, J. D., Chitnis, C. E., Craig, A. G., Roberts, D. J., Hudson-Taylor, D. E., Peterson, D. S., Pinches, R., Newbold, C. I., & Miller, L. H. (1995) · Cell · doi:10.1016/0092-8674(95)90056-x · Cited by 1,005 · see citing works
Self-citationMalaria parasites and other haemosporidia
Garnhám, P. C. C. (1966) · Medical Entomology and Zoology · Cited by 960 · see citing works
Diversity Considerations in HIV-1 Vaccine Selection
Gaschen, B. K., Taylor, J., Yusim, K., Foley, B. T., Gao, F., Lang, D. M., Novitsky, V., Haynes, B. F., Hahn, B. H., Tanmoy Bhattacharya, A., et al. (2002) · Science · doi:10.1126/science.1070441 · Cited by 811 · see citing works
Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum
Wootton, J. C., Feng, X., Ferdig, M. T., Cooper, R. A., Mu, J., Baruch, D. I., Magill, A. J., & Su, X. (2002) · Nature · doi:10.1038/nature00813 · Cited by 723 · see citing works
Self-citationA Coalescent-Based Method for Detecting and Estimating Recombination From Gene Sequences
McVean, G., Awadalla, P., & Fearnhead, P. (2002) · Genetics · doi:10.1093/genetics/160.3.1231 · Cited by 708 · see citing works
Self-citationSalanti, A., Staalsoe, T., Lavstsen, T., Jensen, A. T. R., Sowa, M. P. K., Arnot, D. E., Hviid, L., & Theander, T. G. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03570.x · Cited by 702 · see citing works
Maternal antibodies block malaria
Fried, M., Nosten, F., Brockman, A., Brabin, B. J., & Duffy, P. E. (1998) · Nature · doi:10.1038/27570 · Cited by 659 · see citing works
Scherf, A., Hernández‐Rivas, R., Buffet, P. A., Bottius, E., Scheidig‐Benatar, C., Pouvelle, B., Gysin, J., & Lanzer, M. (1998) · The EMBO Journal · doi:10.1093/emboj/17.18.5418 · Cited by 611 · see citing works
Evidence for the Involvement of VAR2CSA in Pregnancy-associated Malaria
Salanti, A., Dahlbäck, M., Turner, L., Nielsen, M. A., Barfod, L., Magistrado, P., Jensen, A. T. R., Lavstsen, T., Ofori, M. F., Marsh, K., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041579 · Cited by 604 · see citing works
Freitas-Junior, L. H., Bottius, E., Pirrit, L. A., Deitsch, K., Scheidig‐Benatar, C., Guinet, F., Nehrbass, U., Wellems, T. E., & Scherf, A. (2000) · Nature · doi:10.1038/35039531 · Cited by 552 · see citing works
Developmental selection of var gene expression in Plasmodium falciparum
Chen, Q., Fernandez, V., Sundström, A., Schlichtherle, M., Datta, S., Hagblom, P., & Wahlgren, M. (1998) · Nature · doi:10.1038/28660 · Cited by 534 · see citing works
RevTrans: multiple alignment of coding DNA from aligned amino acid sequences
Wernersson, R. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg609 · Cited by 516 · see citing works
Two-Locus Sampling Distributions and Their Application
Hudson, R. R. (2001) · Genetics · doi:10.1093/genetics/159.4.1805 · Cited by 499 · see citing works
Malaria Parasites and Other Haemosporidia
Brown, H. W. (1967) · JAMA · doi:10.1001/jama.1967.03130050070044 · Cited by 398 · see citing works
Antigenic Variation at the Infected Red Cell Surface in Malaria
Kyes, S., Horrocks, P., & Newbold, C. (2001) · Annual Review of Microbiology · doi:10.1146/annurev.micro.55.1.673 · Cited by 393 · see citing works
The Sick Placenta—The Role of Malaria
Brabin, B. J., Romagosa, C., Abdelgalil, S., Menéndez, C., Verhoeff, F. H., McGready, R. M., Fletcher, K. A., Owens, S., d'Alessandro, U., Nosten, F. H., et al. (2004) · Placenta · doi:10.1016/j.placenta.2003.10.019 · Cited by 374 · see citing works
Lavstsen, T., Salanti, A., Jensen, A. T., Arnot, D. E., & Theander, T. G. (2003) · Malaria Journal · doi:10.1186/1475-2875-2-27 · Cited by 348 · see citing works
Jensen, A. T. R., Magistrado-Coxen, P., Sharp, S., Joergensen, L., Lavstsen, T., Chiucchiuini, A., Salanti, A., Vestergaard, L. S., Lusingu, J., Hermsen, R. C., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040274 · Cited by 322 · see citing works
Phylogeny of the malarial genus Plasmodium, derived from rRNA gene sequences.
Escalante, A. A., & Ayala, F. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.24.11373 · Cited by 316 · see citing works
Adhesion of Plasmodium falciparum-infected erythrocytes to hyaluronic acid in placental malaria
Beeson, J. G., Rogerson, S. J., Cooke, B. M., Reeder, J. C., Chai, W., Lawson, A. M., Molyneux, M. E., & Brown, G. V. (2000) · Nature Medicine · doi:10.1038/71582 · Cited by 310 · see citing works
Ricke, C. H., Staalsoe, T., Koram, K., Akanmori, B. D., Riley, E. M., Theander, T. G., & Hviid, L. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.3309 · Cited by 303 · see citing works
Staalsoe, T., Shulman, C. E., Bulmer, J. N., Kawuondo, K., Marsh, K., & Hviid, L. (2004) · The Lancet · doi:10.1016/s0140-6736(03)15386-x · Cited by 288 · see citing works
Smith, J. D., Subramanian, G., Gamain, B., Baruch, D. I., & Miller, L. H. (2000) · Molecular and Biochemical Parasitology · doi:10.1016/s0166-6851(00)00279-6 · Cited by 276 · see citing works
Self-citationBeeson, J. G., Brown, G. V., Molyneux, M. E., Mhango, C., Dzinjalamala, F., & Rogerson, S. J. (1999) · The Journal of Infectious Diseases · doi:10.1086/314899 · Cited by 266 · see citing works
Duffy, P. E., & Fried, M. (2003) · Infection and Immunity · doi:10.1128/iai.71.11.6620-6623.2003 · Cited by 260 · see citing works
Evolutionary origin of human and primate malarias: evidence from the circumsporozoite protein gene.
Escalante, A. A., Barrio, E., & Ayala, F. J. (1995) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040241 · Cited by 246 · see citing works
Kraemer, S. M., & Smith, J. D. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03814.x · Cited by 227 · see citing works
Self-citationNielsen, M. A., Staalsoe, T., Kurtzhals, J. A. L., Goka, B. Q., Dodoo, D., Alifrangis, M., Theander, T. G., Akanmori, B. D., & Hviid, L. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3444 · Cited by 207 · see citing works
Robinson, B. A., Welch, T. L., & Smith, J. D. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03378.x · Cited by 205 · see citing works
Self-citationRecombination Hotspots and Population Structure in Plasmodium falciparum
Mu, J., Awadalla, P., Duan, J., McGee, K., Joy, D. A., McVean, G., & Su, X. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030335 · Cited by 198 · see citing works
Self-citationPlasmodium falciparum Variant Surface Antigen Expression Patterns during Malaria
Bull, P. C., Berriman, M., Kyes, S., Quail, M. A., Hall, N., Kortok, M., Marsh, K., & Newbold, C. (2005) · PLoS Pathogens · doi:10.1371/journal.ppat.0010026 · Cited by 189 · see citing works
High Level of<i>var2csa</i>Transcription by<i>Plasmodium falciparum</i>Isolated from the Placenta
Tuikue Ndam, N. G., Salanti, A., Bertin, G., Dahlbäck, M., Fievet, N., Turner, L., Gaye, A., Theander, T., & Deloron, P. (2005) · The Journal of Infectious Diseases · doi:10.1086/430933 · Cited by 179 · see citing works
Bull, P. C., Kortok, M., Kai, O. K., Ndungu, F. M., Ross, A. J., Lowe, B. S., Newbold, C., & Marsh, K. (2000) · The Journal of Infectious Diseases · doi:10.1086/315652 · Cited by 173 · see citing works
Staalsoe, T., Megnekou, R., Fievét, N., Ricke, C. H., Zornig, H. D., Leke, R., Taylor, D. W., Deloron, P., & Hviid, L. (2001) · The Journal of Infectious Diseases · doi:10.1086/322809 · Cited by 161 · see citing works
A study of var gene transcription in vitro using universal var gene primers☆
Taylor, H. M., Kyes, S. A., Harris, D. E., Kriek, N., & Newbold, C. (2000) · Molecular and Biochemical Parasitology · doi:10.1016/s0166-6851(99)00159-0 · Cited by 155 · see citing works
Chromosome-wide SNPs reveal an ancient origin for Plasmodium falciparum
Mu, J., Duan, J., Makova, K. D., Joy, D. A., Huynh, C. Q., Branch, O. H., Li, W., & Su, X. (2002) · Nature · doi:10.1038/nature00836 · Cited by 152 · see citing works
Self-citationVar gene diversity in Plasmodium falciparum is generated by frequent recombination events
Taylor, H. M., Kyes, S. A., & Newbold, C. (2000) · Molecular and Biochemical Parasitology · doi:10.1016/s0166-6851(00)00286-3 · Cited by 147 · see citing works
Gamain, B., Trimnell, A. R., Scheidig, C., Scherf, A., Miller, L. H., & Smith, J. D. (2005) · The Journal of Infectious Diseases · doi:10.1086/428137 · Cited by 145 · see citing works
Self-citationA well‐conserved Plasmodium falciparum var gene shows an unusual stage‐specific transcript pattern
Kyes, S., Christodoulou, Z., Raza, A., Horrocks, P., Pinches, R. A., Rowe, J. A., & Newbold, C. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03505.x · Cited by 127 · see citing works
Protein Glycosylation in the Malaria Parasite
Gowda, D. C., & Davidson, E. A. (1999) · Parasitology Today · doi:10.1016/s0169-4758(99)01412-x · Cited by 107 · see citing works
Duffy, M. F., Byrne, T. J., Elliott, S. R., Wilson, D. W., Rogerson, S. J., Beeson, J. G., Noviyanti, R., & Brown, G. V. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04577.x · Cited by 93 · see citing works
Identification of a ConservedPlasmodium falciparum varGene Implicated in Malaria in Pregnancy
Rowe, J. A., Kyes, S., Rogerson, S. J., Babiker, H. A., & Raza, A. (2002) · The Journal of Infectious Diseases · doi:10.1086/339684 · Cited by 85 · see citing works
Excess Polymorphisms in Genes for Membrane Proteins in Plasmodium falciparum
Volkman, S. K., Hartl, D. L., Wirth, D. F., Nielsen, K. M., Choi, M., Batalov, S., Zhou, Y., Plouffe, D., Roch, K. G. L., Abagyan, R. A., et al. (2002) · Science · doi:10.1126/science.1075642 · Cited by 83 · see citing works
Bull, P. C., Lowe, B. S., Kaleli, N., Njuga, F., Kortok, M., Ross, A. J., Ndungu, F. M., Snow, R. W., & Marsh, K. (2002) · The Journal of Infectious Diseases · doi:10.1086/340420 · Cited by 80 · see citing works
Winter, G., Chen, Q., Flick, K., Kremsner, P., Fernandez, V., & Wahlgren, M. (2003) · Molecular and Biochemical Parasitology · doi:10.1016/s0166-6851(03)00004-5 · Cited by 75 · see citing works
Ndam, N. T., Fiévet, N., Bertin, G. I., Cottrell, G., Gaye, A., & Deloron, P. (2004) · The Journal of Infectious Diseases · doi:10.1086/425521 · Cited by 67 · see citing works
Beeson, J. G., Mann, E. J., Byrne, T. J., Caragounis, A., Elliott, S. R., Brown, G. V., & Rogerson, S. J. (2006) · The Journal of Infectious Diseases · doi:10.1086/500145 · Cited by 61 · see citing works
Genetic diversity of the DBLα region in Plasmodium falciparum var genes among Asia-Pacific isolates☆
Fowler, E. V., Peters, J. M., Gatton, M. L., Chen, N., & Cheng, Q. (2002) · Molecular and Biochemical Parasitology · doi:10.1016/s0166-6851(01)00443-1 · Cited by 58 · see citing works
Cox, S. E., Staalsøe, T., Arthur, P., Bulmer, J. N., Hviid, L., Yeboah‐Antwi, K., Kirkwood, B. R., & Riley, E. M. (2005) · Infection and Immunity · doi:10.1128/iai.73.5.2841-2847.2005 · Cited by 32 · see citing works
Kraemer, S. M., Gupta, L., & Smith, J. D. (2003) · Molecular and Biochemical Parasitology · doi:10.1016/s0166-6851(03)00099-9 · Cited by 16 · see citing works
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Expression switching in the stevor and Pfmc‐2TM superfamilies in Plasmodium falciparum
Lavazec, C., Sanyal, S., & Templeton, T. J. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05767.x · Cited by 659 · see citing works
Plasmodium falciparum Erythrocyte Membrane Protein 1 Diversity in Seven Genomes – Divide and Conquer
Rask, T. S., Hansen, D. A., Theander, T. G., Pedersen, A. G., & Lavstsen, T. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000933 · Cited by 373 · see citing works
A family affair: var genes, PfEMP1 binding, and malaria disease
Kraemer, S. M., & Smith, J. D. (2006) · Current Opinion in Microbiology · doi:10.1016/j.mib.2006.06.006 · Cited by 291 · see citing works
Self-citationLavstsen, T., Turner, L., Saguti, F., Magistrado-Coxen, P., Rask, T. S., Jespersen, J. S., Wang, C. W., Berger, S. S., Baraka, V., Marquard, A. M., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120455109 · Cited by 270 · see citing works
Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome
Mu, J., Awadalla, P., Duan, J., McGee, K., Keebler, J., Seydel, K. B., McVean, G., & Su, X. (2006) · Nature Genetics · doi:10.1038/ng1924 · Cited by 223 · see citing works
Self-citationThe future for blood‐stage vaccines against malaria
Richards, J. S., & Beeson, J. G. (2009) · Immunology and Cell Biology · doi:10.1038/icb.2009.27 · Cited by 215 · see citing works
Claessens, A., Hamilton, W. L., Kekre, M., Otto, T. D., Faizullabhoy, A., Rayner, J. C., & Kwiatkowski, D. P. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004812 · Cited by 210 · see citing works
Kraemer, S. M., Kyes, S., Aggarwal, G., Springer, A., Nelson, S. O., Christodoulou, Z., Smith, L. M., Wang, W., Levin, E., Newbold, C., et al. (2007) · BMC Genomics · doi:10.1186/1471-2164-8-45 · Cited by 203 · see citing works
Self-citationPopulation Genomics of the Immune Evasion (var) Genes of Plasmodium falciparum
Barry, A. E., Leliwa-Sytek, A., Tavul, L., Imrie, H., Migot-Nabias, F., Brown, S. M., McVean, G. A. V., & Day, K. P. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030034 · Cited by 199 · see citing works
Malaria in Pregnancy: Linking Immunity and Pathogenesis to Prevention
Rogerson, S. J., Mwapasa, V., & Meshnick, S. R. (2007) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.77.6.suppl.14 · Cited by 183 · see citing works
Wassmer, S. C., Taylor, T. E., Rathod, P. K., Mishra, S. K., Mohanty, S., Arévalo‐Herrera, M., Duraisingh, M. T., & Smith, J. D. (2015) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.14-0841 · Cited by 180 · see citing works
Self-citationKyes, S., Kraemer, S. M., & Smith, J. D. (2007) · Eukaryotic Cell · doi:10.1128/ec.00173-07 · Cited by 171 · see citing works
Self-citation(2015) · Advances in Parasitology · doi:10.1016/bs.apar.2015.02.004 · Cited by 162 · see citing works
Plasmodium falciparum var gene expression is modified by host immunity
Warimwe, G. M., Keane, T., Fegan, G., Musyoki, J., Newton, C. R. J. C., Pain, A., Berriman, M., Marsh, K., & Bull, P. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907590106 · Cited by 147 · see citing works
Jackson, A. P., Otto, T. D., Darby, A. C., Ramaprasad, A., Xia, D., Echaide, I. E., Farber, M. D., Gahlot, S., Gamble, J. A., Gupta, D. K., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku322 · Cited by 130 · see citing works
Investigating the Host Binding Signature on the Plasmodium falciparum PfEMP1 Protein Family
Janes, J. H., Wang, C., Levin-Edens, E., Vigan-Womas, I., Guillotte-Blisnick, M., Melcher, M., Mercereau‐Puijalon, O., & Smith, J. D. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002032 · Cited by 126 · see citing works
Self-citationMolecular Epidemiology of Malaria
Conway, D. J. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00021-06 · Cited by 121 · see citing works
Bockhorst, J., Lu, F., Janes, J. H., Keebler, J., Gamain, B., Awadalla, P., Su, X.-Z., Samudrala, R., Jojic, N., & Smith, J. D. (2007) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2007.06.007 · Cited by 117 · see citing works
Self-citationRecent insights into humoral and cellular immune responses against malaria
Beeson, J. G., Osier, F. H. A., & Engwerda, C. R. (2008) · Trends in Parasitology · doi:10.1016/j.pt.2008.08.008 · Cited by 115 · see citing works
Genetic linkage and association analyses for trait mapping in Plasmodium falciparum
Su, X., Hayton, K., & Wellems, T. E. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2126 · Cited by 113 · see citing works
Self-citationBarfod, L., Bernasconi, N. L., Dahlbäck, M., Jarrossay, D., Andersen, P. H., Salanti, A., Ofori, M. F., Turner, L., Resende, M., Nielsen, M. A., et al. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05503.x · Cited by 110 · see citing works
Amulic, B., Salanti, A., Lavstsen, T., Nielsen, M. A., & Deitsch, K. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000256 · Cited by 107 · see citing works
A Network Approach to Analyzing Highly Recombinant Malaria Parasite Genes
Larremore, D. B., Clauset, A. J., & Buckee, C. O. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003268 · Cited by 103 · see citing works
Dahlbäck, M., Rask, T. S., Andersen, P. H., Nielsen, M. A., Ndam, N. T., Resende, M., Turner, L., Deloron, P., Hviid, L., Lund, O., et al. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020124 · Cited by 98 · see citing works
Bull, P. C., Buckee, C. O., Kyes, S., Kortok, M., Thathy, V., Guyah, B., Stoute, J. A., Newbold, C., & Marsh, K. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06248.x · Cited by 97 · see citing works
Host-Malaria Parasite Interactions and Impacts on Mutual Evolution
Su, X., Zhang, C., & Joy, D. A. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.587933 · Cited by 92 · see citing works
Self-citationAdvances and challenges in malaria vaccine development
Wang, R., Smith, J. D., & Kappe, S. H. I. (2009) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399409001318 · Cited by 84 · see citing works
Self-citationVar2CSA minimal CSA binding region is located within the N-terminal region
Srivastava, A., Gangnard, S., Dechavanne, S., Amirat, F., Lewit Bentley, A., Bentley, G. A., & Gamain, B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020270 · Cited by 76 · see citing works
Ghumra, A., Semblat, J., Ataíde, R., Kifude, C., Adams, Y., Claessens, A., Anong, D. N., Bull, P. C., Fennell, C., Arman, M., et al. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002665 · Cited by 80 · see citing works
Default Pathway of var2csa Switching and Translational Repression in Plasmodium falciparum
Mok, B. W.-Y., Ribacke, U., Rasti, N., Kironde, F., Chen, Q., Nilsson, P., & Wahlgren, M. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001982 · Cited by 79 · see citing works
Disruption of Var2csa Gene Impairs Placental Malaria Associated Adhesion Phenotype
Viebig, N. K., Levin, E., Dechavanne, S., Rogerson, S. J., Gysin, J., Smith, J. D., Scherf, A., & Gamain, B. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000910 · Cited by 79 · see citing works
Self-citationDifferential var gene expression in the organs of patients dying of falciparum malaria
Montgomery, J. L., Mphande, F. A., Berriman, M., Pain, A., Rogerson, S. J., Taylor, T. E., Molyneux, M. E., & Craig, A. G. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05837.x · Cited by 74 · see citing works
Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA.
Ma, R., Lian, T., Huang, R., Renn, J. P., Petersen, J. D., Zimmerberg, J., Duffy, P. E., & Tolia, N. H. (2021) · Nature Microbiology · doi:10.1038/s41564-020-00858-9 · Cited by 72 · see citing works
Malaria vaccine R&D in the Decade of Vaccines: Breakthroughs, challenges and opportunities
Birkett, A. J., Moorthy, V., Loucq, C., Chitnis, C. E., & Kaslow, D. C. (2013) · Vaccine · doi:10.1016/j.vaccine.2013.02.040 · Cited by 70 · see citing works
The impact of malaria parasitism: from corpuscles to communities.
Wellems, T., Hayton, K., & Fairhurst, R. M. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38307 · Cited by 89 · see citing works
DC8 and DC13 var Genes Associated with Severe Malaria Bind Avidly to Diverse Endothelial Cells
Avril, M., Brazier, A. J., Melcher, M., Sampath, S., & Smith, J. D. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003430 · Cited by 69 · see citing works
Self-citationVAR2CSA and protective immunity against pregnancy-associatedPlasmodium falciparummalaria
Hviid, L., & Salanti, A. (2007) · Parasitology · doi:10.1017/s0031182007000121 · Cited by 69 · see citing works
Rasti, N., Namusoke, F., Chêne, A., Chen, Q., Staalsoe, T., Klinkert, M.-Q., Mirembe, F., Kironde, F., & Wahlgren, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601519103 · Cited by 69 · see citing works
Tutterrow, Y. L., Avril, M., Singh, K., Long, C. A., LEKE, R. J. I., Sama, G., Salanti, A., Smith, J. D., Leke, R. G. F., & Taylor, D. W. (2012) · Infection and Immunity · doi:10.1128/iai.00071-12 · Cited by 65 · see citing works
Self-citationHow malaria modulates memory: activation and dysregulation of B cells in Plasmodium infection
Scholzen, A., & Sauerwein, R. W. (2013) · Trends in Parasitology · doi:10.1016/j.pt.2013.03.002 · Cited by 63 · see citing works
An approach to classifying sequence tags sampled from Plasmodium falciparum var genes
Bull, P. C., Kyes, S., Buckee, C. O., Montgomery, J. L., Kortok, M., Newbold, C., & Marsh, K. (2007) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2007.03.011 · Cited by 64 · see citing works
Shape-shifting gametocytes: how and why does P. falciparum go banana-shaped?
Dixon, M. W. A., Dearnley, M. K., Hanssen, E. G., Gilberger, T., & Tilley, L. M. (2012) · Trends in Parasitology · doi:10.1016/j.pt.2012.07.007 · Cited by 64 · see citing works
Analysis ofPlasmodium falciparum varGenes Expressed in Children from Papua New Guinea
Falk, N., Kaestli, M., Qi, W., Ott, M., Baea, K., Cortés, A., & Beck, H. (2009) · The Journal of Infectious Diseases · doi:10.1086/600071 · Cited by 64 · see citing works
Bigey, P., Gnidehou, S., Doritchamou, J., Quiviger, M., Viwami, F., Couturier, A., Salanti, A., Nielsen, M. A., Scherman, D., Deloron, P., et al. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir499 · Cited by 63 · see citing works
Genetics of antigenic variation in Plasmodium falciparum
Dzikowski, R., & Deitsch, K. (2009) · Current Genetics · doi:10.1007/s00294-009-0233-2 · Cited by 61 · see citing works
Oleinikov, A. V., Rossnagle, E., Francis, S., Mutabingwa, T. K., Fried, M., & Duffy, P. E. (2007) · The Journal of Infectious Diseases · doi:10.1086/518513 · Cited by 59 · see citing works
Klein, M. M., Gittis, A. G., Su, H.-P., Makobongo, M. O., Moore, J. M., Singh, S. P., Miller, L. H., & Garboczi, D. N. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000147 · Cited by 55 · see citing works
Benavente, E. D., Oresegun, D. R., de Sessions, P. F., Walker, E. M., Roper, C., Dombrowski, J. G., de Souza, R. M., Marinho, C. R. F., Sutherland, C. J., Hibberd, M. L., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-33767-3 · Cited by 47 · see citing works
First-Trimester Plasmodium falciparum Infections Display a Typical “Placental” Phenotype
Doritchamou, J., Bertin, G. I., Moussiliou, A., Bigey, P., Viwami, F., Ezinmègnon, S., Fiévet, N., Massougbodji, A., Deloron, P., & Ndam, N. T. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis629 · Cited by 52 · see citing works
Ape parasite origins of human malaria virulence genes
Larremore, D. B., Sundararaman, S. A., Liu, W., Proto, W. R., Clauset, A. J., Loy, D. E., Speede, S., Plenderleith, L. J., Sharp, P. M., Hahn, B. H., et al. (2015) · Nature Communications · doi:10.1038/ncomms9368 · Cited by 52 · see citing works
Beeson, J. G., Ndungu, F. M., Persson, K. E. M., Chesson, J. M., Kelly, G., Uyoga, S. M., Hallamore, S. L., Williams, T. N., Reeder, J. C., Brown, G. V., et al. (2007) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2007.77.22 · Cited by 53 · see citing works
Hypervariable antigen genes in malaria have ancient roots
Zilversmit, M. M., Chase, E. K., Chen, D. S., Awadalla, P., Day, K. P., & McVean, G. (2013) · BMC Evolutionary Biology · doi:10.1186/1471-2148-13-110 · Cited by 51 · see citing works
Self-citationAvril, M., Kulasekara, B. R., Gose, S. O., Rowe, C. G., Dahlbäck, M., Duffy, P. E., Fried, M., Salanti, A., Misher, L., Narum, D. L., et al. (2008) · Infection and Immunity · doi:10.1128/iai.01470-07 · Cited by 52 · see citing works
Self-citationUkaegbu, U. E., Zhang, X., Heinberg, A. R., Wélé, M., Chen, Q., & Deitsch, K. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005234 · Cited by 51 · see citing works
Magistrado, P. A., Minja, D., Doritchamou, J., Tuikue Ndam, N., John, D., Schmiegelow, C., Massougbodji, A., Dahlbäck, M., Ditlev, S. B., Pinto, V. V., et al. (2011) · Vaccine · doi:10.1016/j.vaccine.2010.10.080 · Cited by 49 · see citing works
Pregnancy-associated malaria: Parasite binding, natural immunity and vaccine development
Gamain, B., Smith, J. D., Viebig, N. K., Gysin, J., & Scherf, A. (2006) · International Journal for Parasitology · doi:10.1016/j.ijpara.2006.11.011 · Cited by 49 · see citing works
Self-citationHavlíková, S., Roller, L., Koči, J., Trimnell, A. R., Kazimírová, M., Klempa, B., & Nuttall, P. A. (2009) · International Journal for Parasitology · doi:10.1016/j.ijpara.2009.05.005 · Cited by 47 · see citing works
Self-citationVigan-Womas, I., Guillotte-Blisnick, M., Juillerat, A., Vallières, C., Lewit‐Bentley, A., Tall, A., Baril, L., Bentley, G. A., & Mercereau‐Puijalon, O. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016544 · Cited by 46 · see citing works
Bancells, C., & Deitsch, K. (2013) · Molecular Microbiology · doi:10.1111/mmi.12379 · Cited by 45 · see citing works
Brolin, K., Ribacke, U., Nilsson, S., Ankarklev, J., Moll, K., Wahlgren, M., & Chen, Q. (2009) · Genome biology · doi:10.1186/gb-2009-10-10-r117 · Cited by 44 · see citing works
Recent advances in malaria genomics and epigenomics
Kirchner, S., Power, B. J., & Waters, A. P. (2016) · Genome Medicine · doi:10.1186/s13073-016-0343-7 · Cited by 44 · see citing works
Several domains from VAR2CSA can induce Plasmodium falciparum adhesion-blocking antibodies
Salanti, A., Resende, M., Ditlev, S. B., Pinto, V. V., Dahlbäck, M., Andersen, G., Manczak, T., Theander, T. G., & Nielsen, M. A. (2010) · Malaria Journal · doi:10.1186/1475-2875-9-11 · Cited by 42 · see citing works
Avril, M., Cartwright, M. M., Hathaway, M. J., Hommel, M., Elliott, S. R., Williamson, K., Narum, D. L., Duffy, P. E., Fried, M., Beeson, J. G., et al. (2010) · Infection and Immunity · doi:10.1128/iai.00410-09 · Cited by 39 · see citing works
Self-citationGrabitzki, J., & Lochnit, G. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.09.035 · Cited by 39 · see citing works
Rosetting in Plasmodium falciparum: A cytoadherence phenotype with multiple actors
Mercereau‐Puijalon, O., Guillotte-Blisnick, M., & Vigan-Womas, I. (2008) · Transfusion Clinique et Biologique · doi:10.1016/j.tracli.2008.04.003 · Cited by 36 · see citing works
Zhang, Q., Zhang, Y., Huang, Y., Xue, X., Yan, H., Sun, X., Wang, J., McCutchan, T. F., & Pan, W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020591 · Cited by 36 · see citing works
Beeson, J. G., Andrews, K. T., Boyle, M. J., Duffy, M. F., Choong, E. K., Byrne, T. J., Chesson, J. M., Lawson, A. M., & Chai, W. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700231200 · Cited by 36 · see citing works
The case for PfEMP1-based vaccines to protect pregnant women againstPlasmodium falciparummalaria
Hviid, L. (2011) · Expert Review of Vaccines · doi:10.1586/erv.11.113 · Cited by 35 · see citing works
Schneider, V. M., Visone, J. E., Harris, C. T., Florini, F., Hadjimichael, E., Zhang, X., Gross, M., Rhee, K. Y., Mamoun, C. B., Kafsack, B. F. C., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2302152120 · Cited by 34 · see citing works
Malaria parasite detection increases during pregnancy in wild chimpanzees
Nys, H. M. D., Calvignac‐Spencer, S., Boesch, C., Dorny, P., Wittig, R. M., Mundry, R., & Leendertz, F. H. (2014) · Malaria Journal · doi:10.1186/1475-2875-13-413 · Cited by 34 · see citing works
Patel, J. C., Hathaway, N. J., Parobek, C. M., Thwai, K. L., Madanitsa, M., Khairallah, C., Kalilani‐Phiri, L., Mwapasa, V., Massougbodji, A., Fiévet, N., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-04737-y · Cited by 34 · see citing works
Genetic and genomic analyses of host-pathogen interactions in malaria
Bongfen, S. E., Laroque, A., Berghout, J., & Gros, P. (2009) · Trends in Parasitology · doi:10.1016/j.pt.2009.05.012 · Cited by 34 · see citing works
Utilizing nanobody technology to target non-immunodominant domains of VAR2CSA
Ditlev, S. B., Florea, R., Nielsen, M. A., Theander, T. G., Magez, S., Boeuf, P., & Salanti, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084981 · Cited by 31 · see citing works
Avril, M., Cartwright, M. M., Hathaway, M. J., & Smith, J. D. (2011) · Malaria Journal · doi:10.1186/1475-2875-10-36 · Cited by 30 · see citing works
Self-citationBryant, J. M., Regnault, C., Scheidig‐Benatar, C., Baumgarten, S., Guizetti, J., & Scherf, A. (2017) · mBio · doi:10.1128/mbio.00729-17 · Cited by 30 · see citing works
Doritchamou, J., Bigey, P., Nielsen, M. A., Gnidehou, S., Ezinmegnon, S., Burgain, A., Massougbodji, A., Deloron, P., Salanti, A., & Ndam, N. T. (2013) · Vaccine · doi:10.1016/j.vaccine.2013.07.072 · Cited by 29 · see citing works
Wang, C. W., Lavstsen, T., Bengtsson, D. C., Magistrado-Coxen, P., Berger, S. S., Marquard, A. M., Alifrangis, M., Lusingu, J., Theander, T. G., & Turner, L. (2012) · Malaria Journal · doi:10.1186/1475-2875-11-129 · Cited by 29 · see citing works
Molecular Principles of Intrauterine Growth Restriction in Plasmodium Falciparum Infection
Seitz, J., Prieto, D. M. M., Fávaro, R. R., Schneider, H., & Markert, U. R. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00098 · Cited by 29 · see citing works
Brolin, K. J. M., Persson, K. E. M., Wahlgren, M., Rogerson, S. J., & Chen, Q. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009230 · Cited by 24 · see citing works
“VAR2CSA is a member of the PfEMP1 family but displays a different domain architecture than typical PfEMP1s and has an unusual high sequence conservation between isolates [12,13].”
BackgroundSingh, K., Gitti, R. K., Diouf, A., Zhou, H., Gowda, D. C., Miura, K., Ostazeski, S. A., Fairhurst, R. M., Garboczi, D. N., & Long, C. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.118612 · Cited by 25 · see citing works
Knobs, Adhesion, and Severe Falciparum Malaria
Wiser, M. F. (2023) · Tropical Medicine and Infectious Disease · doi:10.3390/tropicalmed8070353 · Cited by 24 · see citing works
Bordbar, B., Ndam, N. T., Renard, E., Jafari‐Guemouri, S., Tavul, L., Jennison, C., Gnidehou, S., Tahar, R., Gamboa, D., Bendezú, J., et al. (2014) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2014.04.010 · Cited by 23 · see citing works
Pre-clinical and clinical development of the first placental malaria vaccine
Pehrson, C., Salanti, A., Theander, T. G., & Nielsen, M. A. (2017) · Expert Review of Vaccines · doi:10.1080/14760584.2017.1322512 · Cited by 25 · see citing works
Doritchamou, J., Sabbagh, A., Jespersen, J. S., Renard, E., Salanti, A., Nielsen, M. A., Deloron, P., & Tuikue Ndam, N. (2015) · PLOS ONE · doi:10.1371/journal.pone.0137695 · Cited by 22 · see citing works
Doritchamou, J., Teo, A., Morrison, R., Arora, G., Kwan, J., Manzella‐Lapeira, J., Medina, S., Langhorne, J., Hviid, L., Narum, D. L., et al. (2019) · Infection and Immunity · doi:10.1128/iai.00865-18 · Cited by 22 · see citing works
Optimizing expression of the pregnancy malaria vaccine candidate, VAR2CSA in Pichia pastoris
Avril, M., Hathaway, M. J., Cartwright, M. M., Gose, S. O., Narum, D. L., & Smith, J. D. (2009) · Malaria Journal · doi:10.1186/1475-2875-8-143 · Cited by 21 · see citing works
Self-citationAntigenic Variation in Plasmodium falciparum
Petter, M., & Duffy, M. F. (2015) · Results and problems in cell differentiation · doi:10.1007/978-3-319-20819-0_3 · Cited by 21 · see citing works
Joergensen, L., Vestergaard, L. S., Turner, L., Magistrado-Coxen, P., Lusingu, J., Lemnge, M., Theander, T. G., & Jensen, A. T. R. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.1.428 · Cited by 20 · see citing works
Malaria evolution in South Asia: Knowledge for control and elimination
Narayanasamy, K., Chery, L., Basu, A., Duraisingh, M. T., Escalante, A. A., Fowble, J. W., Güler, J. L., Herricks, T., Kumar, A., Majumder, P. P., et al. (2012) · Acta Tropica · doi:10.1016/j.actatropica.2012.01.008 · Cited by 19 · see citing works
Self-citationPinto, V. V., Ditlev, S. B., Jensen, K. E., Resende, M., Dahlbäck, M., Andersen, G., Andersen, P., Theander, T. G., Salanti, A., & Nielsen, M. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017942 · Cited by 18 · see citing works
Gnidehou, S., Jessen, L. E., Gangnard, S., Ermont, C., Triqui, C., Quiviger, M., Guitard, J., Lund, O., Deloron, P., & Ndam, N. T. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013105 · Cited by 18 · see citing works
Gangnard, S., Badaut, C., Ramboarina, S., Baron, B., Ramdani, T., Gamain, B., Deloron, P., Lewit‐Bentley, A., & Bentley, G. A. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.02.014 · Cited by 18 · see citing works
Hommel, M., Chan, J.-A., Umbers, A. J., Langer, C., Rogerson, S. J., Smith, J. D., & Beeson, J. G. (2018) · Parasites & Vectors · doi:10.1186/s13071-018-2653-7 · Cited by 17 · see citing works
Self-citationVariant-Specific Immunity to Plasmodium berghei in Pregnant Mice
Megnekou, R., Hviid, L., & Staalsøe, T. (2009) · Infection and Immunity · doi:10.1128/iai.01321-08 · Cited by 17 · see citing works
Mugasa, J. P., Qi, W., Rusch, S., Rottmann, M., & Beck, H. (2012) · Malaria Journal · doi:10.1186/1475-2875-11-230 · Cited by 17 · see citing works
Doritchamou, J., Sossou-tchatcha, S., Cottrell, G., Moussiliou, A., Houngbeme, C. H., Massougbodji, A., Deloron, P., & Ndam, N. T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098577 · Cited by 16 · see citing works
Badaut, C., Bertin, G. I., Rustico, T., Fiévet, N., Massougbodji, A., Gaye, A., & Deloron, P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011276 · Cited by 17 · see citing works
Plasmodium falciparum population dynamics in a cohort of pregnant women in Senegal
Guitard, J., Andersen, P., Ermont, C., Gnidehou, S., Fiévet, N., Lund, O., Deloron, P., & Ndam, N. T. (2010) · Malaria Journal · doi:10.1186/1475-2875-9-165 · Cited by 16 · see citing works
Timm, T., Annoscia, G., Klein, J., & Lochnit, G. (2017) · Molecules · doi:10.3390/molecules22122094 · Cited by 16 · see citing works
Muhle, R., Adjalley, S. H., Falkard, B., Nkrumah, L. J., Muhle, M. E., & Fidock, D. A. (2009) · International Journal for Parasitology · doi:10.1016/j.ijpara.2009.05.001 · Cited by 15 · see citing works
- Authors
- Trimnell, A. R., Kraemer, S. M., Mukherjee, S., Phippard, D. J., Janes, J. H., Flamoe, E., Su, X.-Z., Awadalla, P., & Smith, J. D.
- Affiliations
- Center for Infectious Disease Research (US)
- National Institutes of Health (US)
- North Carolina State University (US)
- Corresponding author
- Awadalla, Philip
- Smith, Joseph D.
- Venue
- Molecular and Biochemical Parasitology
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 148
- Issue
- 2
- Pages
- 169-180
- ISSN
- 0166-6851 (ISSN-L)
- OpenAlex
- W1996773860
- Cited by
- 165
- References
- 57
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 8 · 2016: 1 · 2015: 8 · 2014: 14 · 2013: 11 · 2012: 14
- FWCI
- 19.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Molecular and Biochemical Parasitology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- European Commission
- National Institute of Allergy and Infectious Diseases (R01AI047953, R01 AI4795301A1)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Hematology › Blood groups and transfusion
- Life Sciences › Immunology and Microbiology › Parasitology › Bird parasitology and diseases
- Keywords
- Plasmodium falciparum, var genes, VAR2CSA, placental malaria, Plasmodium reichenowi, erythrocyte adhesion, immune evasion
- MeSH terms
- Amino Acid Sequence, Animals, Antigenic Variation, Child, Female, Humans, Molecular Sequence Data, Placenta, Placenta Diseases, Plasmodium falciparum, Pregnancy, Severity of Illness Index, Genetic Variation, Pregnancy Complications, Parasitic, Malaria, Falciparum, Genes, Protozoan, Sequence Analysis, DNA, Evolution, Molecular
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