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Down‐Regulation of Anti‐CD3 Antibody‐Induced IL‐4 Production by Bovine Caseins Hydrolysed with Lactobacillus GG‐Derived Enzymes
Abstract
A prerequisite for systemic hyporesponsiveness to dietary antigens is their processing in the gut. This study investigated whether bovine caseins degraded by enzymes of an intestinal bacterial strain, Lactobacillus GG (ATCC 53103), could regulate the cytokine production by anti‐CD3 antibody‐induced peripheral blood mononuclear cells of 14 atopic patients, aged 5–29 (mean, 16) months. Purified casein up‐regulated the interleukin‐4 and interferon‐γ production, P = 0.008 and P = 0.008, respectively. Conversely, Lactobacillus GG‐degraded casein down‐regulated the interleukin‐4 production, P = 0.003, with no effect on interferon‐γ. These results indicate that intestinal bacteria may modify immunomodulatory properties of native food proteins and introduce a promising tool to provide protection from potentially harmful dietary antigens at a young age.
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Cited by
Functional food science and gastrointestinal physiology and function
Salminen, S., Bouley, C., Boutron, M.-C., Cummings, J. H., Franck, A., Gibson, G. R., Isolauri, E., Moreau, M.-C., Roberfroid, M., & Rowland, I. (1998) · British Journal of Nutrition · doi:10.1079/bjn19980108 · Cited by 1,398
Self-citationDistinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing
Kalliomäki, M., Kirjavainen, P., Eerola, E., Kero, P., Salminen, S., & Isolauri, E. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.111237 · Cited by 1,255
Self-citationProbiotics: effects on immunity
Isolauri, E., Sütas, Y., Kankaanpää, P., Arvilommi, H., & Salminen, S. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.444s · Cited by 1,019
Self-citationPASSCLAIM1?Gut health and immunity
Cummings, J. H., Antoine, J.-M., Azpiroz, F., Bourdet-Sicard, R., Brandtzaeg, P., Calder, P. C., Gibson, G. R., Guarner, F., Isolauri, E., Pannemans, D., et al. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-1205-4 · Cited by 324
Self-citationLeBlanc, J., Fliss, I., & Matar, C. (2004) · Clinical and Vaccine Immunology · doi:10.1128/cdli.11.6.1171-1181.2004 · Cited by 106
Metadata
- Authors
- SÜTAS, Y., HURME, M., & ISOLAURI, E.
- Venue
- Scandinavian Journal of Immunology
- Publisher
- Wiley
- Published
- 1996-06
- Volume
- 43
- Issue
- 6
- Pages
- 687-689
- ISSN
- 0300-9475 (ISSN-L)
- 1365-3083
- OpenAlex
- W2005628478
- Cited by
- 177
- References
- 0
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Down‐Regulation of Anti‐CD3 Antibody‐Induced IL‐4 Production by Bovine Caseins Hydrolysed with Lactobacillus GG‐Derived Enzymes. https://app.cochat.ai/papers/10.1046/j.1365-3083.1996.d01-258.x
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- SÜTAS, Y., HURME, M., & ISOLAURI, E. (1996). Down‐Regulation of Anti‐CD3 Antibody‐Induced IL‐4 Production by Bovine Caseins Hydrolysed with Lactobacillus GG‐Derived Enzymes. Scandinavian Journal of Immunology. https://doi.org/10.1046/j.1365-3083.1996.d01-258.x
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