The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Ku80‐ and DNA ligase IV‐deficient plants are sensitive to ionizing radiation and defective in T‐DNA integration
Abstract
Summary: Double‐strand break (DSB) repair pathways catalyze the rejoining of broken chromosomes and the integration of transforming DNAs. These processes have been well characterized in bacteria, fungi, and animals. Plants are generally thought primarily to utilize a non‐homologous end joining (NHEJ) pathway to repair DSBs and integrate transgenes, as transforming DNAs with large tracts of homology to the chromosome are integrated at random. In order to test the hypothesis that NHEJ is an important pathway for the repair of DSBs in plants, we isolated T‐DNA insertion mutations in the Arabidopsis homologs of the Ku80 and DNA ligase IV genes, required for the initiation and completion, respectively, of NHEJ. Both mutants were hypersensitive to the cytostatic effects of gamma radiation, suggesting that NHEJ is indeed a critical pathway for the repair of DSBs. T‐DNA insertion rates were also decreased in the mutants, indicating that Ku80 and DNA ligase IV play an important role in either the mechanism or the regulation of T‐DNA integration in Arabidopsis.
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Citations
Cites
Chromosomal stability and the DNA double-stranded break connection
van Gent, D. C., Hoeijmakers, J. H. J., & Kanaar, R. (2001) · Nature Reviews Genetics · doi:10.1038/35056049 · Cited by 1,219
Hefner, E. (2003) · Journal of Experimental Botany · doi:10.1093/jxb/erg069 · Cited by 94
The Arabidopsis UVH1 Gene Is a Homolog of the Yeast Repair Endonuclease RAD1
Fidantsef, A. L., Mitchell, D. L., & Britt, A. B. (2000) · Plant Physiology · doi:10.1104/pp.124.2.579 · Cited by 72
Self-citationUV- and Gamma-Radiation Sensitive Mutants of Arabidopsis thaliana
Jiang, C.-Z., Yen, C.-N., Cronin, K., Mitchell, D., & Britt, A. B. (1997) · Genetics · doi:10.1093/genetics/147.3.1401 · Cited by 56
Self-citation
Cited by
Agrobacterium-mediated genetic transformation of plants: biology and biotechnology
Tzfira, T., & Citovsky, V. (2006) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2006.01.009 · Cited by 451
Repair of DNA double strand breaks by non-homologous end joining
Lees-Miller, S. (2003) · Biochimie · doi:10.1016/j.biochi.2003.10.011 · Cited by 366
Agrobacterium-Mediated Plant Transformation: Biology and Applications
Hwang, H.-H., Yu, M., & Lai, E.-M. (2017) · The Arabidopsis Book · doi:10.1199/tab.0186 · Cited by 312
Agrobacterium T-DNA integration: molecules and models
TZFIRA, T. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.06.004 · Cited by 311
Kimura, S., & Sakaguchi, K. (2006) · Chemical Reviews · doi:10.1021/cr040482n · Cited by 167
Metadata
- Authors
- Friesner, J., & Britt, A. B.
- Venue
- The Plant Journal
- Publisher
- Wiley
- Published
- 2003-05
- Volume
- 34
- Issue
- 4
- Pages
- 427-440
- ISSN
- 0960-7412 (ISSN-L)
- 1365-313X
- OpenAlex
- W2149099892
- Cited by
- 162
- References
- 4
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Friesner, J., & Britt, A. B. (2003). Ku80‐ and DNA ligase IV‐deficient plants are sensitive to ionizing radiation and defective in T‐DNA integration. The Plant Journal. https://doi.org/10.1046/j.1365-313x.2003.01738.x
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