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Cited by 163Helminth infection and controlParasites and Host InteractionsParasitic Diseases Research and Treatment

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Anthelmintic resistance in human helminths: a review

Geerts, S., Gryseels, B.·2001·Tropical Medicine & International Health
DOI 10.1046/j.1365-3156.2001.00774.x
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Abstract

We briefly review reports on drug resistance in human helminths and compare the factors which contribute to the development of anthelmintic resistance in livestock and man, i.e. high treatment frequency, single‐drug regimens, targeting and timing of mass treatments and underdosing. Conclusions are drawn from the mistakes in the treatment and control of livestock helminths. The advantages and inconveniences of current methods for the detection of drug resistance in helminths of livestock are discussed and some suggestions are put forward to standardize the tests for the detection of resistance in human helminths. Finally, based on veterinary experience, some recommendations are made to reduce the risks of development of drug resistance in human helminths. The dramatic and rapid spread of resistance to all major classes of veterinary anthelmintics should be a warning against too strong a reliance on drugs in helminth control programmes.

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Metadata

Authors
Geerts, S., & Gryseels, B.
Affiliations
Instituut voor Tropische Geneeskunde (BE)
Corresponding author
Geerts, S.
ORCID
Geerts, S.
Venue
Tropical Medicine & International Health
Publisher
Wiley
Published
2001-11
Volume
6
Issue
11
Pages
915-921
ISSN
  • 1360-2276 (ISSN-L)
  • 1365-3156
DOI
10.1046/j.1365-3156.2001.00774.x
OpenAlex
W2128079521
Cited by
163
References
0
Citations by year
2026: 4 · 2025: 4 · 2024: 8 · 2023: 7 · 2022: 8 · 2021: 17 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 8 · 2016: 6 · 2015: 10 · 2014: 9 · 2013: 10 · 2012: 6
FWCI
2.09
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 73 d)
Locations
  • Tropical Medicine & International Health (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Parasitology › Helminth infection and control
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
  • Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
Keywords
anthelmintic resistance, human helminths, mass drug administration, treatment frequency, underdosing, drug resistance detection, veterinary anthelmintics
MeSH terms
Animals, Anthelmintics, Drug Resistance, Helminthiasis, Helminths, Humans, Species Specificity, Parasitic Sensitivity Tests

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