Association of a putative regulatory polymorphism in the PD‐1 gene with susceptibility to type 1 diabetes

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

Freeman, G. J., Long, A. J., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitz, L. J., Malenkovich, N., Okazaki, T., Byrne, M. C., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1027 · Cited by 5,294

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

Nishimura, H., Nose, M., Hiai, H., Minato, N., & Honjo, T. (1999) · Immunity · doi:10.1016/s1074-7613(00)80089-8 · Cited by 2,749

Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4

Takahashi, T., Tagami, T., Yamazaki, S., Uede, T., Shimizu, J., Sakaguchi, N., Mak, T. W., & Sakaguchi, S. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.2.303 · Cited by 2,233

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

Salomon, B. L., Lenschow, D. J., Rhee, L., Ashourian, N., Singh, B., Sharpe, A. H., & Bluestone, J. A. (2000) · Immunity · doi:10.1016/s1074-7613(00)80195-8 · Cited by 2,058

CD4+CD25high Regulatory Cells in Human Peripheral Blood

Baecher‐Allan, C., Brown, J. A., Freeman, G. J., & Hafler, D. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.3.1245 · Cited by 1,889

Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

Nishimura, H., Okazaki, T., Tanaka, Y., Nakatani, K., Hara, M., Matsumori, A., Sasayama, S., Mizoguchi, A., Hiai, H., Minato, N., et al. (2001) · Science · doi:10.1126/science.291.5502.319 · Cited by 1,868

HLA‐DR typing by PCR amplification with sequence‐specific primers (PCR‐SSP) in 2 hours: An alternative to serological DR typing in clinical practice including donor‐recipient matching in cadaveric transplantation

Olerup, O., & Zetterquist, H. (1992) · Tissue Antigens · doi:10.1111/j.1399-0039.1992.tb01940.x · Cited by 1,820

The B7–CD28 superfamily

Sharpe, A. H., & Freeman, G. J. (2002) · Nature reviews. Immunology · doi:10.1038/nri727 · Cited by 1,759

PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

Okazaki, T., Maeda, A., Nishimura, H., Kurosaki, T., & Honjo, T. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231486598 · Cited by 873

CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells

Suri‐Payer, E., Amar, A. Z., Thornton, A. M., & Shevach, E. M. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.3.1212 · Cited by 858

Current advances in the human lupus genetics

Shen, N., & Tsao, B. P. (2004) · Current Rheumatology Reports · doi:10.1007/s11926-004-0014-3 · Cited by 35

Exploring immune checkpoint inhibitors: Focus on PD-1/PD-L1 axis and beyond

Aden, D., Zaheer, S., Sureka, N., Trisal, M., Chaurasia, J. K., & Zaheer, S. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.155864 · Cited by 37

Expansion of effector T cells associated with decreased PD-1 expression in patients with indolent B cell lymphomas and chronic lymphocytic leukemia

Tonino, S. H., van de Berg, P. J., Yong, S. L., ten Berge, I. J. M., Kersten, M. J., van Lier, R. A. W., van Oers, M. H. J., & Kater, A. P. (2012) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2012.673224 · Cited by 34

Recent advances in immune checkpoint inhibitor-induced type 1 diabetes mellitus

Liao, D., Liu, C., Chen, S., Liu, F., Li, W., Shangguan, D., & Shi, Y. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110414 · Cited by 35

Sex‐specific association of the human PTPN22 1858T‐allele with type 1 diabetes

Nielsen, C., Hansen, D., Husby, S., & Lillevang, S. T. (2007) · International Journal of Immunogenetics · doi:10.1111/j.1744-313x.2007.00720.x · Cited by 33

Association of programmed cell death-1 (PDCD-1) gene polymorphisms with rheumatoid arthritis in Iranian patients.

Tahoori, M. T., Pourfathollah, A. A., Akhlaghi, M., Daneshmandi, S., Nicknam, M. H., & Soleimanifar, N. (2011) · PubMed · Cited by 33

Cellular and molecular regulation of the programmed death-1/programmed death ligand system and its role in multiple sclerosis and other autoimmune diseases

Ibañez-Vega, J., Vilchez, C., Jimenez, K., Carlos Guevara, O., Burgos, P. I., & Naves, R. F. (2021) · Journal of Autoimmunity · doi:10.1016/j.jaut.2021.102702 · Cited by 33

The applied basic research of systemic lupus erythematosus based on the biological omics

Sui, W., Hou, X., Che, W., Yang, M., & Dai, Y. (2013) · Genes and Immunity · doi:10.1038/gene.2013.3 · Cited by 31

Structure and function of programmed death (PD) molecules

Folkl, A., & Bienzle, D. (2009) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2009.10.006 · Cited by 30

Lack of an association of programmed cell death-1 PD1.3 polymorphism with risk of hepatocellular carcinoma susceptibility in Turkish population: A case–control study

Bayram, S., Akkız, H., Ülger, Y., Bekar, A., Akgöllü, E., & Yıldırım, S. (2012) · Gene · doi:10.1016/j.gene.2012.09.119 · Cited by 27

PD-1 gene polymorphic variation is linked with first symptom of disease and severity of relapsing-remitting form of MS

Pawlak, E., Nowak, O., Karabon, L., Pokryszko‐Dragan, A., Partyka, A., Tomkiewicz, A., Ptaszkowski, J., Frydecka, I., Podemski, R., Dybko, J., et al. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.02.006 · Cited by 29

Association Between Hepatitis B Viral Burden in Chronic Infection and a Functional Single Nucleotide Polymorphism of the PDCD1 Gene

Zheng, L., Li, D., Wang, F., Wu, H., Li, X., Fu, J., Chen, X., Wang, L., Liu, Y., & Wang, S. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9450-1 · Cited by 28

Genetic polymorphisms and surface expression of CTLA-4 and PD-1 on T cells of silica-exposed workers

Rocha, M. C., dos Santos, L. M. B., Bagatin, E., Tervaert, J. W. C., Damoiseaux, J. G. M. C., Lido, A. V., Longhini, A. L. F., Torello, C. O., & Queiroz, M. L. S. (2011) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2011.10.010 · Cited by 27

Programmed Death-1: From gene to protein in autoimmune human myasthenia gravis

Sakthivel, P., Ramanujam, R., Wang, X. B., Pirskanen, R., & Lefvert, A. K. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.09.019 · Cited by 27

Personalized Immunotherapies for Type 1 Diabetes: Who, What, When, and How?

Deligne, C., You, S., & Mallone, R. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12040542 · Cited by 26

Study of Programmed Cell Death 1 (PDCD1) Gene Polymorphims in Iranian Patients with Ankylosing Spondylitis

Soleimanifar, N., Amirzargar, A. A., Mahmoudi, M., Pourfathollah, A. A., Azizi, E., Jamshidi, A., Rezaei, N., Tahoori, M. T., Bidad, K., Nikbin, B., et al. (2010) · Inflammation · doi:10.1007/s10753-010-9282-4 · Cited by 26

The function of a novel immunophenotype candidate molecule PD-1 in chronic lymphocytic leukemia

Grzywnowicz, M., Karabon, L., Karczmarczyk, A., Zajac, M., Skórka, K., Zaleska, J., Własiuk, P., Chocholska, S., Tomczak, W., Bojarska-Junak, A. A., et al. (2015) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2015.1017820 · Cited by 26

Type 1 diabetes pathogenesis and the role of inhibitory receptors in islet tolerance

Martinov, T., & Fife, B. T. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14106 · Cited by 28

Fine mapping of a region on chromosome 21q21.11–q22.3 showing linkage to type 1 diabetes

Bergholdt, R., Nerup, J., & Pociot, F. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2004.022004 · Cited by 25

Critical co-stimulatory pathways in the stability of Foxp3+ Treg cell homeostasis in Type I Diabetes

Kornete, M., & Piccirillo, C. A. (2011) · Autoimmunity Reviews · doi:10.1016/j.autrev.2011.08.007 · Cited by 24

PD-1 pathway-mediated regulation of islet-specific CD4+ T cell subsets in autoimmune diabetes

Martinov, T., Spanier, J. A., Pauken, K. E., & Fife, B. T. (2016) · Immunoendocrinology · doi:10.14800/ie.1164 · Cited by 24

T cell costimulation and coinhibition: genetics and disease.

Scandiuzzi, L., Ghosh, K., & Zang, X. (2011) · PubMed · Cited by 24

No evidence of association of the PDCD1 gene with Type 1 diabetes

Fawwaz, S., Nikamo, P., Törn, C., Landin‐Olsson, M., Lernmark, Å., Alarcón-Riquelme, M. E., Kockum, I. S., & the Diabetes Incidence in Sweden Study Group (2007) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02297.x · Cited by 24

Autoimmune Ovarian Disease in Day 3-Thymectomized Mice: The Neonatal Time Window, Antigen Specificity of Disease Suppression, and Genetic Control

Tun, K. S. K., Setiady, Y. Y., Samy, E. T., Lewis, J., & Teuscher, C. (2005) · Springer eBooks · doi:10.1007/3-540-27702-1_10 · Cited by 24

Association of programmed death‐1 gene polymorphisms with the risk of basal cell carcinoma

Fathi, F., Ebrahimi, M., Eslami, A., Hafezi, H., Eskandari, N., & Motedayyen, H. (2019) · International Journal of Immunogenetics · doi:10.1111/iji.12447 · Cited by 22

Detect it so you can treat it: A case series and proposed checklist to detect neurotoxicity in checkpoint therapy

Bolz, S., Ramakrishnan, T., Fleischer, M., Livingstone, E., Stolte, B., Thimm, A., Kizina, K., Ugurel, S., Kleinschnitz, C., Glas, M., et al. (2021) · eNeurologicalSci · doi:10.1016/j.ensci.2021.100324 · Cited by 22

CMTM6 as a master regulator of PD-L1

Yaseen, M. M., Abuharfeil, N. M., & Darmani, H. (2022) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-022-03171-y · Cited by 25

Pathophysiology, diagnosis, and management of immune checkpoint inhibitor-induced diabetes mellitus

Kani, E.-R., Karaviti, E., Karaviti, D., Gerontiti, E., Paschou, I. A., Saltiki, K., Stefanaki, K., Ψαλτοπούλου, Θ., & Paschou, S. Α. (2024) · Endocrine · doi:10.1007/s12020-024-04050-5 · Cited by 22

Patient-Centered Diabetes Care of Cancer Patients

Kotwal, A., Cheung, Y.-M. M., Cromwell, G. E., Drincic, A., Leblebjian, H., Quandt, Z., Rushakoff, R. J., & McDonnell, M. E. (2021) · Current Diabetes Reports · doi:10.1007/s11892-021-01435-y · Cited by 23

Rs2227982 and rs2227981 in PDCD1 gene are functional SNPs associated with T1D risk in East Asian

Gu, Y., Xiao, L., Gu, W., Chen, S., Feng, Y., Wang, J., Wang, Z., Cai, Y., Chen, H., Xu, X., et al. (2018) · Acta Diabetologica · doi:10.1007/s00592-018-1152-9 · Cited by 21

Programmed death-1 (PD-1) gene polymorphisms lodged in the genetic predispositions of Kawasaki Disease

Chun, J.-K., Kang, D. W., Yoo, B. W., Shin, J., & Kim, D. S. (2009) · European Journal of Pediatrics · doi:10.1007/s00431-009-1002-4 · Cited by 21

Blocking Type I Interferon Signaling Rescues Lymphocytes from Oxidative Stress, Exhaustion, and Apoptosis in a Streptozotocin-Induced Mouse Model of Type I Diabetes

Ibrahim, H. M., El-Elaimy, I. A., Eldien, H. M. S., Badr, B. M., Rabah, D. M., & Badr, G. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/148725 · Cited by 20

Association between a PD-1 gene polymorphism and antisperm antibody-related infertility in Iranian men

Zamani, M. R., Asbagh, F. A., Massoud, A. H., Salmaninejad, A., Massoud, A. M., & Rezaei, N. (2014) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-014-0371-4 · Cited by 20

Association study between B‐ and T‐lymphocyte attenuator gene and type 1 diabetes mellitus or systemic lupus erythematosus in the Japanese population

Inuo, M., Ihara, K., Matsuo, T., Kohno, H., & Hara, T. (2009) · International Journal of Immunogenetics · doi:10.1111/j.1744-313x.2008.00809.x · Cited by 20

Unveiling the Etiopathogenic Spectrum of Hypophysitis: A Narrative Review

Menotti, S., Giampietro, A., Raia, S., Veleno, M., Angelini, F., Tartaglione, T., Gaudino, S., Doglietto, F., Marinis, L. D., Pontecorvi, A., et al. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13081210 · Cited by 19

Inborn Errors of Immunity and Their Phenocopies: CTLA4 and PD-1

Hao, Y., & Cook, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.806043 · Cited by 21

Polymorphisms of Genes for Programmed Cell Death 1 Ligands in Patients with Rheumatoid Arthritis

Wang, S., Lin, C.-H., Li, R., Ou, T., Wu, C., Tsai, W., Liu, H., & Yen, J. (2007) · Journal of Clinical Immunology · doi:10.1007/s10875-007-9113-z · Cited by 18

Pathogenesis of Systemic Lupus Erythematosus

Hahn, B. H., & Tsao, B. P. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-3285-4.10074-9 · Cited by 18

Insights Into the Host Contribution of Endocrine Associated Immune-Related Adverse Events to Immune Checkpoint Inhibition Therapy

Chye, A., Allen, I., Barnet, M. B., & Burnett, D. L. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.894015 · Cited by 17

Trinucleotide repeats of programmed cell death-1 gene are associated with susceptibility to type 1 diabetes mellitus

Hiromine, Y., Ikegami, H., Fujisawa, T., Nojima, K., Kawabata, Y., Noso, S., Asano, K., Fukai, A., & Ogihara, T. (2007) · Metabolism · doi:10.1016/j.metabol.2007.01.021 · Cited by 17

Recent Advances in the Genetics of Autoimmune Diseases

Alarcón-Riquelme, M. E. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1423.001 · Cited by 17

Frequencies of PD-1- positive T CD3+CD4+, T CD3+CD8+ and B CD19+ lymphocytes in female patients with Graves' disease and healthy controls– preliminary study

Pyzik, A., Grywalska, E., Matyjaszek‐Matuszek, B., Smoleń, A., Pyzik, D., & Roliński, J. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.03.006 · Cited by 17

Polimorfismos del gen del receptor de muerte celular programada 1 (PDCD1) y diabetes tipo 1 en población Chilena

R, S. F., Beems, M. V., Amaya Oyarzún, A., Elena Carrasco, P., & Francisco Pérez, B. (2010) · Revista médica de Chile · doi:10.4067/s0034-98872010000500003 · Cited by 16

Programmed cell death 1 gene (PDCD1) polymorphism and pemphigus foliaceus (fogo selvagem) disease susceptibility

Braun-Prado, K., & Petzl‐Erler, M. L. (2007) · Genetics and Molecular Biology · doi:10.1590/s1415-47572007000300003 · Cited by 16

No evidence of association between genetic variants of the PDCD1 ligands and SLE

Abelson, A.-K., Johansson, C., Kozyrev, S. V., Kristjansdottir, H., Gunnarsson, I., Svenungsson, E., Jönsen, A., Lima, G., Scherbarth, H. R., Gamron, S., et al. (2006) · Genes and Immunity · doi:10.1038/sj.gene.6364360 · Cited by 16

The Role of Programmed Death-1 in Type 1 Diabetes

Tucker, C., Dwyer, A. J., Fife, B. T., & Martinov, T. (2021) · Current Diabetes Reports · doi:10.1007/s11892-021-01384-6 · Cited by 16

T-regulatory cells infected with feline immunodeficiency virus up-regulate programmed death-1 (PD-1)

Achleitner, A., Clark, M. E., & Bienzle, D. (2011) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2011.06.009 · Cited by 15

PD-1 Haplotype Combinations and Susceptibility of Patients to Squamous Cell Carcinomas of Head and Neck

Fathi, F., Faghih, Z., Khademi, B., Kayedi, T., Erfani, N., & Gahderi, A. (2018) · Immunological Investigations · doi:10.1080/08820139.2018.1538235 · Cited by 14

An exon polymorphism of programmed cell death 1 gene is associated with both the susceptibility and thoracolumbar kyphosis severity of ankylosing spondylitis in a Chinese Han population

Qian, B., Wang, X.-Q., Qiu, Y., Jiang, H., Ji, M.-L., & Jiang, J. (2013) · Journal of Orthopaedic Science · doi:10.1007/s00776-013-0385-2 · Cited by 14

Lack of an Association of PD-1 and Its Ligand Genes with Behcet's Disease in a Chinese Han Population

Meng, Q., Guo, H., Hou, S., Jiang, Z., Kijlstra, A., & Yang, P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025345 · Cited by 14

Polymorphism in programmed cell death 1 gene is strongly associated with lung and kidney allograft survival in recipients from CMV-positive donors

Forconi, C. S., Gatault, P., Miquelestorena‐Standley, E., Noble, J., Al-Hajj, S., Guillemain, R., Stern, M., Hoffmann, T., Prat, L., Suberbielle, C., et al. (2016) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2016.08.014 · Cited by 14

Immune inhibitory proteins and their pathogenic and therapeutic implications in autoimmunity and autoimmune hepatitis

Czaja, A. J. (2019) · Autoimmunity · doi:10.1080/08916934.2019.1641200 · Cited by 15

The genetics of systemic lupus erythematosus: understanding how SNPs confer disease susceptibility

Alarcón-Riquelme, M. E. (2006) · Springer Seminars in Immunopathology · doi:10.1007/s00281-006-0033-4 · Cited by 14

The genetics of shared autoimmunity

Alarcón-Riquelme, M. E. (2005) · Autoimmunity · doi:10.1080/08916930500050236 · Cited by 14

Improving Power of Genome-Wide Association Studies with Weighted False Discovery Rate Control and Prioritized Subset Analysis

Lin, W., & Lee, W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033716 · Cited by 13

Association between polymorphisms in PDCD1 gene and aplastic anemia in Chinese Han population

Wu, Z.-X., Miao, M., Qiu, Y., Qin, Z., Wang, J., Jiang, Y., Ming, Z., & Zhang, X. (2013) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2013.772605 · Cited by 13

Genetic and nongenetic factors that may predispose individuals to allergic drug reactions

Gibson, A., Ogese, M. O., & Pirmohamed, M. (2018) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000459 · Cited by 13

Molecular and Genetic Immune Biomarkers of Primary and Immune-Therapy Induced Hypophysitis: From Laboratories to the Clinical Practice

Chiloiro, S., Russo, F., Tartaglione, T., & Capoluongo, E. D. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11101026 · Cited by 12

Mice Producing Less Reactive Oxygen Species Are Relatively Resistant to Collagen Glycopeptide Vaccination against Arthritis

Batsalova, T., Dzhambazov, B. M., Klaczkowska, D., & Holmdahl, R. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000385 · Cited by 12

Genetic variation in the multifunctional transcription factor Yy1 and type 1 diabetes mellitus in the BB rat

Klöting, N., & Klöting, I. (2004) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2004.04.007 · Cited by 12

From Single Nucleotide Polymorphisms to Constant Immunosuppression: Mesenchymal Stem Cell Therapy for Autoimmune Diseases

Chinnadurai, R., Waller, E. K., Galipeau, J., & Nooka, A. K. (2013) · BioMed Research International · doi:10.1155/2013/929842 · Cited by 11

Treating tumors with immune checkpoint inhibitors: Rationale and limitations

Seidel, J. A., Otsuka, A., & Kabashima, K. (2017) · Trends in Immunotherapy · doi:10.24294/ti.v1.i1.20 · Cited by 11

Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis

Cheng, L. Z., Tang, X., Liu, L., Peng, J., Nishiura, K., Cheung, A. K. L., Guo, J., Wu, X., Tang, H. Y., An, M., et al. (2015) · mAbs · doi:10.1080/19420862.2015.1016695 · Cited by 11

Checkpoint Inhibitor-Induced Autoimmune Diabetes: An Autoinflammatory DiseasePreprint

Quandt, Z., Perdigoto, A. L., Anderson, M. S., & Herold, K. C. (2024) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041603 · Cited by 13

Inducible T-cell costimulator (ICOS ) and CD28 polymorphisms possibly play a role in the pathogenesis of chronic autoreactive urticaria

Brzoza, Z., Grzeszczak, W., Trautsolt, W., & Moczulski, D. K. (2017) · Clinical and Experimental Dermatology · doi:10.1111/ced.13212 · Cited by 10

Lack of association of programmed cell death 1 gene (PDCD1) polymorphisms with susceptibility to chronic urticaria in patients with positive autologous serum skin test.

Brzoza, Z., Grzeszczak, W., Trautsolt, W., & Moczulski, D. K. (2012) · PubMed · Cited by 10

Polymorphisms in PDCD1 gene are not associated with Wegener’s granulomatosis

Sakthivel, P., Giscombe, R., Ramanujam, R., & Lefvert, A. K. (2009) · Rheumatology International · doi:10.1007/s00296-009-0952-1 · Cited by 10

Association of three systemic lupus erythematosus susceptibility factors, PD‐1.3A, C4AQ0, and low levels of mannan‐binding lectin, with autoimmune manifestations in icelandic multicase systemic lupus erythematosus families

Kristjansdottir, H., Saevarsdóttir, S., Gröndal, G., Alarcón-Riquelme, M. E., Erlendsson, K., Valdimarsson, H., & Steinsson, K. (2008) · Arthritis & Rheumatism · doi:10.1002/art.24129 · Cited by 10

CAR T-cell therapy in hematologic and solid malignancies: mechanisms, clinical applications, and future directions

Anitha, K., Chenchula, S., Vardhan, K. V., Padmavathi, R., Varshini, T. S., Amerneni, L. S., Amerneni, K. C., & Chavan, M. R. (2025) · Medical Oncology · doi:10.1007/s12032-025-02923-x · Cited by 12

The dysfunction of natural killer cells is essential for the development of type 1 diabetes

Sabetkam, S., Kalarestaghi, H., Mazloumi, Z., Asl, K. D., Norouzi, N., & Rafat, A. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154556 · Cited by 9

PD-1 Polymorphisms Are Associated with Susceptibility of Acute Anterior Uveitis in Chinese Population

Li, Y., Hong, M., Huang, X., Zhong, L.-P., Gu, Y., Wang, D., Wang, Y., Lan, Y., Lou, Y., & Zheng, M. (2018) · DNA and Cell Biology · doi:10.1089/dna.2018.4417 · Cited by 9

Autoimmune diabetic patients undergoing allogeneic islet transplantation: are we ready for a regulatory T-cell therapy?

Gagliani, N., Ferraro, A. M., Roncarolo, M. G., & Battaglia, M. (2009) · Immunology Letters · doi:10.1016/j.imlet.2009.07.007 · Cited by 9

A Safety Analysis of Programmed Death 1 Pathway Inhibitors in Patients With Solid Tumor Malignancies and Preexisting Autoimmune Disease

Higgins, J. P., Trinh, A. V., Watson, M. L., Beardslee, T. J., Goyal, S., Kudchadkar, R. R., Pakkala, S., Waltuck, J., Momary, K. M., & Byers, K. (2022) · JCR Journal of Clinical Rheumatology · doi:10.1097/rhu.0000000000001863 · Cited by 8

PDCD1 PD-1.3 polymorphism and allergic bronchial asthma in Russian and Buryat patients

Dmitrieva-Zdorova, E. V., Gabaeva, M. V., Seregin, Y., Bodoev, N. V., & Voronko, O. E. (2016) · Journal of Asthma · doi:10.1080/02770903.2016.1196366 · Cited by 8

Association of the T allele of an intronic single nucleotide polymorphism in the colony stimulating factor 1 receptor with Crohn's disease: a case-control study

Zapata-Velandia, A. M., Ng, S.-S., Brennan, R. F., Simonsen, N., Gastañaduy, M., Zabaleta, J., Lentz, J. J., Craver, R. D., Correa, H., Delgado, A., et al. (2004) · Journal of Immune Based Therapies and Vaccines · doi:10.1186/1476-8518-2-6 · Cited by 8

Lack of association between CTLA-4 and PDCD1 polymorphisms and acute rejection in German liver transplant recipients

Thude, H., Schipler, A. D., Treszl, A., Peine, S., Koch, M., Sterneck, M. R., & Nashan, B. (2013) · Human Immunology · doi:10.1016/j.humimm.2013.04.021 · Cited by 7

Re-Enlightenment of Fulminant Type 1 Diabetes under the COVID-19 Pandemic

Sano, H., & Imagawa, A. (2022) · Biology · doi:10.3390/biology11111662 · Cited by 7

Association of PDCD1 polymorphism to systemic lupus erythematosus and rheumatoid arthritis susceptibility

do Canto, L. M., Farias, T. D. J., Medeiros, M. D., Coêlho, C. C., Sereia, A. F. R., Back, L. K. D. C., de Mello, F. M., Zimmermann, A. F., Pereira, I. A., & de Souza, I. R. (2015) · Revista Brasileira de Reumatologia (English Edition) · doi:10.1016/j.rbre.2015.07.008 · Cited by 7

T-cell Inhibitors: A Bench-to-Bedside Review

Das, S., Ariizumi, K., & Cruz, P. D. (2012) · Dermatitis · doi:10.1097/der.0b013e31826e43ed · Cited by 9

Mapping the future of common diseases: lessons from psoriasis

Giardina, E. (2006) · Frontiers in bioscience · doi:10.2741/2169 · Cited by 7

Targeting Immune Modulators in Glioma While Avoiding Autoimmune Conditions

Bitar, L., Schumann, U., König, R., Zipp, F., & Schmidt, M. H. H. (2021) · Cancers · doi:10.3390/cancers13143524 · Cited by 7

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Schuster, C., Brosi, H., Stifter, K., Boehm, B. O., & Schirmbeck, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071746 · Cited by 6

Polymorphisms in PDCD1 gene are not associated with aplastic anemia in Chinese Han population

Ming, Z. J., Hui, H., Miao, M., Qiu, Y., & Zhang, X. (2011) · Rheumatology International · doi:10.1007/s00296-011-2127-0 · Cited by 6

PDCD1 and IFNL4 genetic variants and risk of developing hepatitis C virus‐related diseases

Re, V. D., Tornesello, M. L., Zorzi, M. D., Caggiari, L., Pezzuto, F., Leone, P., Racanelli, V., Lauletta, G., Zanussi, S., Repetto, O., et al. (2020) · Liver International · doi:10.1111/liv.14667 · Cited by 6

Successful treatment of nivolumab and ipilimumab triggered type 1 diabetes by using sodium-glucose transporter 2 inhibitor: a case report and systematic review

Fujiwara, M., Shimizu, M., Okano, T., Maejima, Y., & Shimomura, K. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1264056 · Cited by 5

Molecular Scanning of the Gene for Programmed Cell Death‐1 (PDCD‐1) as a Candidate for Type 1 Diabetes Susceptibility

Hiromine, Y., Ikegami, H., Fujisawa, T., Kawabata, Y., Noso, S., Yamaji, K., ASANO, K., & Ogihara, T. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1375.043 · Cited by 5

Correction to: Programmed death 1 ligand (PD-L1) in solid cancers after allogeneic hematopoietic stem cell transplantation: a retrospective analysis by the Nagasaki Transplant Group

Kasai, S., Itonaga, H., Niino, D., Miyoshi, H., Kato, T., Imanishi, D., Fujioka, M., Furumoto, T., Sato, S., Sawayama, Y., et al. (2020) · International Journal of Hematology · doi:10.1007/s12185-020-03019-0 · Cited by 5

Génétique des maladies systémiques

Dieudé, P. (2007) · Revue du Rhumatisme · doi:10.1016/j.rhum.2007.07.002 · Cited by 4

Understanding type 1 diabetes genetics - approaches for identification of susceptibility genes in multi-factorial diseases.

Bergholdt, R. (2009) · PubMed · Cited by 4

Meta-analysis of genetic polymorphisms in programmed cell death 1 Associations with rheumatoid arthritis, ankylosing spondylitis, and type 1 diabetes susceptibility

Müller‐Ladner, U. (2015) · Cited by 4

Nutrigenomics and Chronic Inflammation

Kok, F., Bouwman, L., & Desiere, F. (2007) · CRC Press eBooks · doi:10.1201/9781420009170-11 · Cited by 4

Programmed death 1 ligand (PD-L1) in solid cancers after allogeneic hematopoietic stem cell transplantation: a retrospective analysis by the Nagasaki Transplant Group

Kasai, S., Itonaga, H., Niino, D., Miyoshi, H., Kato, T., Imanishi, D., Fujioka, M., Furumoto, T., Sato, S., Sawayama, Y., et al. (2020) · International Journal of Hematology · doi:10.1007/s12185-020-02926-6 · Cited by 3

Associação entre o polimorfismo do gene PDCD1 e a susceptibilidade ao lúpus eritematoso sistêmico e à artrite reumatoide

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Potential roles of self-reactive T cells in autoimmunity: lessons from cancer immunology

Andersen, M. H. (2014) · Immunologic Research · doi:10.1007/s12026-014-8559-3 · Cited by 3

Programmed Cell Death-Ligand 1 (PD-L1) gene Single Nucleotide Polymorphism in Graves’ Disease and Hashimoto’s Thyroiditis in Korean Patients

Yoon, J. H., Shin, M., Kim, H. N., Choi, W., Park, J. Y., Hong, A. R., Kim, H. K., & Kang, H. (2021) · Endocrinology and Metabolism · doi:10.3803/enm.2021.965 · Cited by 3

Programmed Death 1 ( PD 1)‐Mediated T ‐Cell Apoptosis and Cancer Immunotherapy

Mandal, C. C., Mehta, J., & Prajapati, V. K. (2018) · Wiley eBooks · doi:10.1002/9781119432463.ch29 · Cited by 4

Circulating T Cell Subsets in Type 1 Diabetes

Ferreira‐Hermosillo, A., Santana-Sánchez, P., Vaquero-García, R., García-Sáenz, M. R., Castro‐Ríos, A., Chávez-Rueda, A. K., Gómez-Díaz, R. A., Chávez-Sanchéz, L., & Legorreta-Haquet, M. V. (2025) · Cells · doi:10.3390/cells14010048 · Cited by 2

Genetics of T cell co-stimulatory receptors -CD28, CTLA4, ICOS and PDCD1 in immunity and transplantation

Haimila, K. (2009) · Cited by 2

Genetic analysis of the exon 1 position 49 CD152 dimorphism in multiple sclerosis

Stuart, R. W., Lovett‐Racke, A. E., Frohman, E. M., Hawker, K., & Racke, M. K. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.09.008 · Cited by 2

Expression of soluble and membrane-bound programmed death protein 1 in psoriasis vulgaris patients

Nagui, N. A. R., Sayed, K. S., Rashed, L. A., & Sayed, H. E. (2018) · Journal of the Egyptian Womenʼs Dermatologic Society · doi:10.1097/01.ewx.0000527924.92973 · Cited by 2

Association of PD-1 and PD-L1 Genetic Polymorphyisms with Type 1 Diabetes Susceptibility

Qian, C., Guo, H., Chen, X., Shi, A., Li, S., Wang, X., Pan, J., & Fang, C. (2018) · Journal of Diabetes Research · doi:10.1155/2018/1614683 · Cited by 43

No evidence of association of the PDCD1 gene with Type 1 diabetes

Fawwaz, S., Nikamo, P., Törn, C., Landin‐Olsson, M., Lernmark, Å., Alarcón-Riquelme, M. E., Kockum, I. S., & the Diabetes Incidence in Sweden Study Group (2007) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02297.x · Cited by 24

PD-1 gene haplotype is associated with the development of type 1 diabetes mellitus in Japanese children

Ni, R., Ihara, K., Miyako, K., Kuromaru, R., Inuo, M., Kohno, H., & Hara, T. (2007) · Human Genetics · doi:10.1007/s00439-006-0309-8 · Cited by 73

The genetic influence of PD-1/PD-L1 axis single nucleotide polymorphisms on the incidence of type 1 diabetes mellitus in pediatric Egyptian patients

Mohamed, R. A., Morgan, D. S., Hodeib, M., Radwan, A., & Ali, H. F. (2022) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-022-00302-z · Cited by 3

Association of PD-1 gene polymorphisms and serum soluble PD-1 levels with type 1 diabetes mellitus susceptibility in a Chinese Han cohort: a case-control study

Zhao, R., Feng, X., Wang, N., Wang, Z., Liu, J., & Wang, G. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1783770