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Cited by 232Diabetes and associated disordersGenetic Associations and EpidemiologyT-cell and B-cell Immunology

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Association of a putative regulatory polymorphism in the PD‐1 gene with susceptibility to type 1 diabetes

Nielsen, C., Hansen, D., Husby, S., Jacobsen, B.B., Lillevang, S.T.·2003·Tissue Antigens
DOI 10.1046/j.1399-0039.2003.00136.x
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Abstract

The immunoreceptor programmed cell death-1 (PD-1) is reported to play an important role in the regulation of peripheral tolerance in rodents, and it was recently shown that a polymorphism in a regulatory site of the PD-1 gene is associated with susceptibility to the autoimmune disease systemic lupus erythematosus (SLE) in humans. We investigated the existence of single-nucleotide polymorphisms (SNPs) in the PD-1 gene in patients with type 1 diabetes in comparison with healthy control subjects, by analyzing 94 children and adolescents with type 1 diabetes diagnosed before their eighteenth birthday (male : female = 52 : 42) and 155 control subjects. Polymorphisms in the complete PD-1 gene (minus the large intron 1) were detected by sequencing. In total, we identified 14 SNPs, of which six have been previously described, including an intronic 7146G/A SNP. We found this polymorphism to be associated with the development of type 1 diabetes [found in 12.2% of diabetic individuals vs 6.8% in controls; odds ratio (OR) = 1.92]. The associated allele is previously shown to alter a transcription factor-binding site (RUNX1/AML1), and the results of this study suggest that this allele could act as an additional susceptibility allele to type 1 diabetes.

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Metadata

Authors
Nielsen, C., Hansen, D., Husby, S., Jacobsen, B. B., & Lillevang, S. T.
Affiliations
Odense University Hospital (DK)
Corresponding author
Lillevang, S.T.
ORCID
Venue
Tissue Antigens
Publisher
Wiley
Published
2003-11-11
Volume
62
Issue
6
Pages
492-497
ISSN
  • 0001-2815 (ISSN-L)
  • 1399-0039
DOI
10.1046/j.1399-0039.2003.00136.x
OpenAlex
W2082012343
Cited by
232
References
20
Citations by year
2026: 2 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 6 · 2021: 13 · 2020: 12 · 2019: 8 · 2018: 9 · 2017: 6 · 2016: 8 · 2015: 9 · 2014: 8 · 2013: 13 · 2012: 9
FWCI
7.40
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Tissue Antigens (publishedVersion)
  • PubMed (publishedVersion)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
type 1 diabetes, single nucleotide polymorphisms, genetic susceptibility, regulatory polymorphisms, transcription factor binding sites, peripheral tolerance, autoimmune disease, children and adolescents
MeSH terms
Adolescent, Alleles, Antigens, Surface, Child, Diabetes Mellitus, Type 1, Female, Gene Frequency, Humans, Lupus Erythematosus, Systemic, Male, Antigens, CD, Linkage Disequilibrium, Case-Control Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Apoptosis Regulatory Proteins, Programmed Cell Death 1 Receptor

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